Common Names: shrubby sophora
Authors isolated flavonoids from traditional Chinese herb and evaluated their activity against phytopathogenic fungi. Kurarinone and sophoraflavanone G showed broad and superior activity, with kurarinone disrupting fungal cell components. Kurarinone could be a potential candidate for plant fungicide development.
Researchers studied Sophora flavescens for potential anti-AD effects due to its compounds. Care because it may lead to new Alzheimer's treatments.
OMT, from S. flavescens, inhibits HMGB1-mediated RAGE/NF-κB activation in sepsis, reducing inflammation and organ injury, prolonging survival rate. Important for treating sepsis.
Oxymatrine from Sophora flavescens induces anti-tumor apoptosis in NSCLC cells by down-regulating TRIM46 and inhibiting the NF-κB pathway. This suggests potential for targeted cancer therapy.
Matrine from a Chinese herb induces autophagy in multiple myeloma cells, leading to cell death. Combining with rapamycin enhances anti-tumor activity. Potential therapeutic strategy targeting ROS/AMPK/mTOR axis.
Researchers compared CHM bath therapy to topical calcipotriol for psoriasis vulgaris. CHM may be as effective as calcipotriol with added benefits from herb combinations. Consider CHM as an alternative treatment for psoriasis.
Study evaluates effectiveness and safety of Compound Kushen Injection (CKI) combined with chemotherapy for treating advanced colorectal cancer. Shows promise in comprehensive treatment of CRC.
This study found that Sophora flavescens extract promotes deep sleep, reduces insomnia symptoms, and activates brain signaling pathways. It could be a potential treatment for insomnia.
Researchers studied the estrogenic activity of 4 prenylated flavonoids from a Japanese medicinal herb. Results suggest potential health benefits and new insights into the herb's therapeutic effects.
Researchers examined the anti-inflammatory effects of Sophora flavescens, finding that flavonoids had stronger inhibition of cytokine production than alkaloids, with prenylated flavanones offering the highest suppression. Prenylation and methoxylation of flavanones improved skin absorption and decreased epidermal thickness in mice, indicating potential for designing new treatments for psoriasis.
Sophoraflavanone G (SG) inhibits MMP-9 expression and protects brain cells by maintaining tight junctions, potentially offering neuroprotection.
Researchers investigated the potential anti-cancer properties of Compound Kushen injection (CKI), a medicine used in Chinese traditional medicine. Results suggest CKI may be effective in treating esophageal cancer.
Ononin, found in medicinal plants, has anti-inflammatory, antioxidant, and antitumor effects. Flavonoids, like ononin, treat major depression, but the exact mechanisms are unknown.
Maackiain (Mac), a compound from Sophora flavescens, shows potential for treating cervical cancer due to its neuroprotective, anti-allergic, anti-inflammatory, and pro-apoptotic properties. Further research is needed to confirm its therapeutic benefits.
Oxymatrine, a natural alkaloid, has antiviral, anti-inflammatory, and immune regulatory effects. Research suggests it may be beneficial for lung cancer patients with COVID-19. Targets include immune regulation, cytoprotection, and control of signaling pathways. Oxymatrine may enhance current treatments for COVID-19 and lung cancer.
Scientists synthesized a new magnetic polymer using environmentally friendly solvents. This polymer was used for extraction of flavonoids, achieving good results in terms of linearity, enrichment factors, and detection limits. The method was successfully applied to determine flavonoids in a plant sample.
Researchers investigated the role of JAK/STAT and PPAR-gamma signaling pathways in multiple sclerosis (MS). They found that matrine, a compound derived from a plant, showed potential neuroprotective effects by inhibiting STAT-3 and mTOR and promoting PPAR-gamma expression. Matrine treatment improved MS symptoms by modulating these pathways.
This study analyzed Sophora flavescens roots and identified new and known alkaloids. Compound 12 showed inhibitory effects on MCF-7 cell growth, making it a potential anti-tumor agent targeting human Rho GTPase activating protein 5 variant and human arachidonate 12-lipoxygenase (12S-type).
Matrine, a compound in Chinese herbal plant, has shown promising anticancer effects on colon cancer. This study investigates how Matrine works and its potential as a therapy for colon cancer.
Matrine, a compound from Sophora flavescens, causes liver injury by disrupting antioxidant pathways and inducing ferroptosis. This study shows that MT reduces cell viability, increases oxidative stress, and alters iron homeostasis. The cytotoxic effects can be reversed by ferroptosis inhibitors, Nrf2 agonists, or selenium supplementation.
A study conducted a comprehensive review to evaluate the effectiveness and safety of heat-clearing and dampness-eliminating Chinese medicine (HDCM) for high-risk cervical HPV-infected patients. This information is important for making informed decisions about treating cervical HPV infections using HDCM.
Researchers assembled a high-quality draft genome of Sophora flavescens, a medicinal plant, using advanced sequencing technology. They identified genes and pathways involved in compound production, providing insight into plant evolution and potential new treatments.
The genomes of Sophora plant species were sequenced, with the smaller genome used to validate the larger one. The study identified pathways for secondary metabolite production, aiding in comparative genomics and data mining for plant natural products.
Researchers studied the effects of a high-fructose and high-fat diet on obesity and fatty liver disease. Their findings can help develop new treatments for these common metabolic disorders.
Matrine (MAT), extracted from Sophora flavescens, inhibits TNBC cell proliferation and invasion, induces apoptosis and autophagy, and inhibits the PI3K/AKT signaling pathway. Promising for TNBC treatment.
The drug combination of Aiton (Kushen) and Franch. (Huanglian) is used to treat laxation. This study focused on their potential anti-cancer effects against colorectal cancer. The research found that a 1:1 ratio of Kushen and Huanglian had the best anti-cancer effect. The active components, matrine and berberine, were evaluated and found to reduce the growth of colorectal cancer in mice. Additionally, the combination of matrine and berberine showed better efficacy than using them alone. The study also identified and quantified the chemical constituents of the drug pair. The findings suggest that the combination of matrine and berberine could inhibit colorectal cancer by improving intestinal microbiota and regulating a signaling pathway.
Bacterial vaginosis (BV) is a common infection caused by anaerobic bacteria. Metronidazole resistance is increasing, but sophora flavescens alkaloids (SFA) can inhibit growth and eliminate biofilms of metronidazole-resistant bacteria. SFAs may help prevent BV recurrence.
Matrine, a compound extracted from a traditional Chinese herb, has been found to have anti-cancer properties in various types of cancer. However, its role in liver cancer has not been well understood. In this study, researchers investigated the effects of matrine on liver cancer cells. They found that matrine reduced cell viability and proliferation, while increasing cell apoptosis. Matrine also inhibited the Warburg effect, a metabolic characteristic of cancer cells. The researchers identified a specific molecular pathway involving circular RNA circROBO1, microRNA miR-130a-5p, and roundabout homolog 1 (ROBO1) that was influenced by matrine. In vivo experiments using a mouse model further supported the anti-cancer effects of matrine. This study provides scientific evidence supporting the potential use of matrine as an effective treatment for liver cancer.
Compound Kushen Injection (CKI), derived from Chinese herbs, contains potent anti-tumor compounds and is commonly used as adjuvant cancer treatment in China, showing promise in fighting tumors and complementing conventional therapies.
Sophora flavescens is a traditional treatment for NSCLC, but the active compounds are not well understood. Previous research suggests that common alkaloids in the plant are only effective at high concentrations. This study aims to identify the key antitumor alkaloids in S. flavescens. This research is important as it could lead to the discovery of novel compounds for more efficient NSCLC treatment options.
Protein misfolding and clumping in the brain may cause multiple neurological illnesses. Matrine, a compound from the Sophora flavescens Aiton plant, may have therapeutic effects on neurological disorders including Multiple Sclerosis and Alzheimer’s. Matrine alters multiple signaling pathways to protect neurons and can cross the blood-brain barrier. This review aims to lay the foundation for future clinical research on matrine as a neuroprotective agent with therapeutic potential for neurodegenerative and neuropsychiatric illnesses. Future research on matrine may lead to exciting discoveries with broader implications.
Kurarinone, a natural compound, can potentially treat Parkinson's disease (PD) by inhibiting the soluble epoxide hydrolase (sEH) enzyme. In a study, kurarinone alleviated MPTP-induced behavioral deficits, dopaminergic neurotoxicity, and neuroinflammation in mice. Kurarinone's inhibition of sEH was supported by evidence of increased sEH substrates and decreased products, along with inhibition kinetics and cocrystallization. The study suggests that sEH is a promising target for PD treatment and that kurarinone could be a natural candidate for it.