Spatholobus suberectus

Ethnobotanical Studies

Studies

Analysis of the Spatholobus suberectus full-length transcriptome identified an R2R3-MYB transcription factor-encoding gene SsMYB158 that regulates flavonoid biosynthesis.

GeneticsPhytochemistry
Qin S et al (2024).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2024.108929
PubMed:
39002304

Plant-Based HSP90 Inhibitors in Breast Cancer Models: A Systematic Review.

Summary

Study identified plant-based compounds as potential HSP90 inhibitors in breast cancer, showing promising antiproliferative effects. Further research is needed to understand their mechanism of action for innovative therapeutic strategies.

Review Cancer
Zarguan I et al (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25105468
PubMed:
38791506

Integration of Network Pharmacology and Experimental Validation to Explore Jixueteng - Yinyanghuo Herb Pair Alleviate Cisplatin-Induced Myelosuppression.

Liu Y et al (2024).
Integr Cancer Ther.
DOI:
10.1177/15347354241237969
PubMed:
38462913

Diversity of fungal community and quality evaluation of Spatholobus Suberectus Dunn during the process of mildew.

Xia C et al (2024).
AMB Express.
DOI:
10.1186/s13568-024-01665-9
PubMed:
38252185

Effective constituents and protective effect of Mudan granules against Schwann cell injury.

Shi Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117692
PubMed:
38176668

Spatholobus suberectus inhibits lipogenesis and tumorigenesis in triple-negative breast cancer via activation of AMPK-ACC and K-Ras-ERK signaling pathway.

Summary

Scientists studied the effects of extract on lipogenesis and tumorigenesis in triple-negative breast cancer (TNBC) by activating specific signaling pathways. This research may provide insights into potential management strategies for TNBC.

Cancer
Zeng X et al (2023).
J Tradit Complement Med.
DOI:
10.1016/j.jtcme.2023.09.002
PubMed:
38020549

Plant Extracts as Skin Care and Therapeutic Agents.

Review
Michalak M et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms242015444
PubMed:
37895122

Morphological and Phylogenetic Analyses Reveal Three New Species of Pestalotiopsis (Sporocadaceae, Amphisphaeriales) from Hainan, China.

Zhang Z et al (2023).
Microorganisms.
DOI:
10.3390/microorganisms11071627
PubMed:
37512800

Spatholobi caulis: A systematic review of its traditional uses, chemical constituents, biological activities and clinical applications.

Review
Pan Y, Luo X and Gong P (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116854
PubMed:
37393029

Maternal traditional Chinese medicine exposure and risk of congenital malformations: a multicenter prospective cohort study.

Peng T et al (2023).
Acta Obstet Gynecol Scand.
DOI:
10.1111/aogs.14553
PubMed:
37073619

An active fraction from Spatholobus suberectus dunn inhibits the inflammatory response by regulating microglia activation, switching microglia polarization from M1 to M2 and suppressing the TLR4/MyD88/NF-κB pathway in LPS-stimulated BV2 cells.

Immunology
Ban M et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e14979
PubMed:
37064439

A comprehensive review: Botany, phytochemistry, traditional uses, pharmacology, and toxicology of Spatholobus suberectus vine stems.

Review Phytochemistry
Huang X et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116500
PubMed:
37062528

A Review of the Pharmacological Potential of Spatholobus suberectus Dunn on Cancer.

Review Cancer
Zhang F et al (2022).
Cells.
DOI:
10.3390/cells11182885
PubMed:
36139460

In-Silico Drug Toxicity and Interaction Prediction for Plant Complexes Based on Virtual Screening and Text Mining.

Zhang F et al (2022).
Int J Mol Sci.
DOI:
10.3390/ijms231710056
PubMed:
36077464

Broad-spectrum antiviral activity of Spatholobus suberectus Dunn against SARS-CoV-2, SARS-CoV-1, H5N1, and other enveloped viruses.

Summary

Scientists have found that an extract of Spatholobus suberectus Dunn (SSP), a medicinal plant, has broad-spectrum antiviral properties against SARS-CoV-1 and 2, HIV-1, and H5N1. SSP effectively inhibits viral entry, with EC values ranging from 3.6 to 5.1 μg/ml. Pre-treatment of pseudovirus or target cells with SSP showed consistent inhibitory activities with the respective EC value of 2.3 or 2.1 μg/ml. SSP blocked both SARS-CoV-2 spike glycoprotein and the host ACE2 receptor without toxic behavior. This plant extract has promising potential to be developed as a drug candidate for preventing and treating COVID-19 and other emerging enveloped viruses.

AntimicrobialCOVID-19
Liu Q et al (2022).
Phytother Res.
DOI:
10.1002/ptr.7452
PubMed:
35943221

Spatholobus suberectus Dunn Water Extract Ameliorates Atopic Dermatitis-Like Symptoms by Suppressing Proinflammatory Chemokine Production In Vivo and In Vitro.

DermatologyImmunology
Song HK et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.919230
PubMed:
35795574

Comparative cytogenomics reveals genome reshuffling and centromere repositioning in the legume tribe Phaseoleae.

Genetics
Montenegro C et al (2022).
Chromosome Res.
DOI:
10.1007/s10577-022-09702-8
PubMed:
35715657

Metabolomics reveals the intervention effect of Zhuang medicine Longzuantongbi granules on a collagen-induced arthritis rat model by using UPLC-MS/MS.

Arthritis
Yao L et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115325
PubMed:
35508204

Erteng Tongbi Decoction ameliorates collagen-induced arthritis in mice via modulating T cell differentiation and cytokines balance.

Immunology
Wei M et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2021.114928
PubMed:
34929309

The Antitriple Negative Breast cancer Efficacy of Spatholobus suberectus Dunn on ROS-Induced Noncanonical Inflammasome Pyroptotic Pathway.

Cancer
Zhang F et al (2021).
Oxid Med Cell Longev.
DOI:
10.1155/2021/5187569
PubMed:
34659633

Spatholobus suberectus Column Extract Inhibits Estrogen Receptor Positive Breast Cancer via Suppressing ER MAPK PI3K/AKT Pathway.

Cancer
Sun JQ et al (2016).
Evid Based Complement Alternat Med.
DOI:
10.1155/2016/2934340
PubMed:
28096885

Protective effect of Spatholobus suberectus on brain tissues in cerebral ischemia.

Summary

Researchers evaluated the neuroprotective effect of SS in rats with cerebral ischemia. The rats were divided into control, ischemia/reperfusion (I/R), and two groups treated with different doses of SS extract for 15 days before I/R. The results showed that SS significantly decreased oxidative stress and DNA damage and increased brain ATP levels and the expression of anti-inflammatory cytokines in the brain tissues of cerebral ischemic rats compared to I/R rats. The study suggests that SS has antioxidant, anti-apoptotic, and anti-inflammatory activity, making it a potential therapeutic agent for preventing neuronal damage from cerebral ischemia.

CardiologyNeuroscience
Zhang R et al (2016).
Am J Transl Res.
PubMed:
27725876

Flavonoids from Spatholobus suberectus.

Phytochemistry
Yoon JS et al (2004).
Arch Pharm Res.
PubMed:
15283457