Spilanthes acmella

Common Names: para cress

Ethnobotanical Studies

Studies

Investigation of the in-vitro lethal effect of spilanthol on demodex and finding the most effective dose.

Kara RO et al (2024).
Arch Dermatol Res.
DOI:
10.1007/s00403-024-03276-7
PubMed:
39177714

Metals stress on soil enzyme activities and herbs defense in the vicinity of high traffic roadways.

Hazarika M et al (2023).
Environ Monit Assess.
DOI:
10.1007/s10661-023-12142-4
PubMed:
38015337

Spilanthes acmella Extract-Based Natural Oils Loaded Emulgel for Anti-Microbial Action against Dermatitis.

Summary

Scientists developed a herbal emulgel containing spilanthol to treat dermal bacterial infections. This is important because current antimicrobial treatments are becoming less effective due to increasing resistance from microbes.

AntimicrobialDermatology
Afzal A et al (2023).
Gels.
DOI:
10.3390/gels9100832
PubMed:
37888404

Biogenic synthesis of iron oxide nanoparticles using leaf extract of Spilanthes acmella: antioxidation potential and adsorptive removal of heavy metal ions.

Sharma R et al (2023).
Environ Monit Assess.
DOI:
10.1007/s10661-023-11860-z
PubMed:
37857875

Effect of SA3X (Spilanthes acmella) Supplementation on Serum Testosterone Levels in Males with Erectile Dysfunction - A Parallel Double-Blind Randomized Controlled Trial.

Endocrinology
Patnaik N, Mishra KG and Pradhan NR (2022).
Maedica (Bucur).
DOI:
10.26574/maedica.2022.17.4.869
PubMed:
36818267

Green Synthesis of Silver Nanoparticles Using Spilanthes acmella Leaf Extract and its Antioxidant-Mediated Ameliorative Activity against Doxorubicin-Induced Toxicity in Dalton's Lymphoma Ascites (DLA)-Bearing Mice.

Immunology
Lalsangpuii F et al (2022).
ACS Omega.
DOI:
10.1021/acsomega.2c05970
PubMed:
36506147

Sesquiterpenoid lactones as potential anti-cancer agents: an update on molecular mechanisms and recent studies.

Review Cancer
Dhyani P et al (2022).
Cancer Cell Int.
DOI:
10.1186/s12935-022-02721-9
PubMed:
36207736

Evaluation of Serum Testosterone Levels Following Three Months of SA3X (Spilanthes acmella) Supplementation.

Endocrinology
Patnaik N, Mishra KG and Pradhan NR (2022).
Cureus.
DOI:
10.7759/cureus.26236
PubMed:
35898380

Randomized, Triple-Blinded, Placebo-Controlled Trial of SA3X (Spilanthes acmella) for the Management of Erectile Dysfunction.

Patnaik N, Mishra KG and Pradhan NR (2022).
Cureus.
DOI:
10.7759/cureus.23989
PubMed:
35541293

Preparation of Spilanthes acmella based emulgel: Antimicrobial study and evaluation.

Antimicrobial
Afzal A et al (2022).
Pak J Pharm Sci.
PubMed:
35228190

Evaluation of effects of Spilanthes acmella extract on muscle mass and sexual potency in males: A population-based study.

Pradhan NR et al (2021).
J Family Med Prim Care.
DOI:
10.4103/jfmpc.jfmpc_746_21
PubMed:
35136796

Protective Efficacy of Spilanthes acmella Murr. Extracts and Bioactive Constituents in Neuronal Cell Death.

Summary

Murr. is a traditional Thai medicine known for its various pharmacological activities. This study investigated the neuroprotective effects of Murr. extracts and bioactive compounds through antioxidative pathways using human neuroblastoma cells. Dexamethasone-induced neuronal cell death was reversed by Murr. MeOH and EtOAc extracts and bioactive compounds, which increased cell viability and reduced reactive oxygen species, autophagy, and apoptosis. Murr. may be a candidate therapy for neuroprotection through its activation of antioxidant marker proteins SOD2 and SIRT3.

Neuroscience
Suwanjang W et al (2022).
Rejuvenation Res.
DOI:
10.1089/rej.2021.0002
PubMed:
35044248

Spilanthes acmella Murr. ameliorates chronic stress through improving mitochondrial function in chronic restraint stress rats.

Suwanjang W et al (2021).
Neurochem Int.
DOI:
10.1016/j.neuint.2021.105083
PubMed:
34052298

Potential Antioxidant and Anti-Inflammatory Effects of Spilanthes acmella and Its Health Beneficial Effects: A Review.

Review Immunology
Abdul Rahim R et al (2021).
Int J Environ Res Public Health.
DOI:
10.3390/ijerph18073532
PubMed:
33805420

Anthelmintic activity of praziquantel and Spilanthes acmella extract on an intestinal cestode parasite.

Gastroenterology
Lalthanpuii PB, Zokimi Z and Lalchhandama K (2020).
Acta Pharm.
DOI:
10.2478/acph-2020-0039
PubMed:
32412429

Neuroprotective effect of Spilanthes acmella Murr. on pesticide-induced neuronal cells death.

Summary

Researchers aimed to test whether extracts from the S. acmella plant could protect dopamine-producing cells in the brain from death caused by exposure to pesticides. They used dopamine-producing cell lines and measured cell death rates. Results showed that S. acmella extracts protected these cells from pesticide-induced death by reducing oxidative stress and inflammation. This suggests that S. acmella could be a potential natural treatment for neurodegenerative diseases, such as Parkinson's, that are caused by the loss of dopamine-producing cells in the brain.

Neuroscience
Suwanjang W et al (2017).
Asian Pac J Trop Med.
DOI:
10.1016/j.apjtm.2016.11.012
PubMed:
28107862

High therapeutic potential of Spilanthes acmella: A review.

Review
Prachayasittikul V et al (2013).
EXCLI J.
PubMed:
27092032