In this study, researchers investigated the effects of apigetrin, a flavonoid found in several herbal medicines, on neuroinflammation. They found that apigetrin reduced the secretion of inflammatory cytokines and decreased the production of prostaglandin E and nitric oxide in mouse microglia cells stimulated with lipopolysaccharide. It also suppressed nuclear expression of nuclear factor kappa B and enhanced expression of antioxidant enzymes in BV-2 cells and had antioxidative activity. Finally, apigetrin inhibited H2O2-induced cell death in hippocampal cells. These findings suggest potential prophylactic activity for neurodegenerative diseases by regulating neuroinflammation, oxidative stress, and neuronal injury.