Common Names: strychnine tree
Network pharmacology and experimental verification were used to study the effects of Semen Strychni on papillary carcinoma thyroid (PTC). Brucine was identified as a suitable marker and showed strong anti-PTC activity, indicating Semen Strychni's potential as a treatment for PTC.
Scientific study investigates Nux Vomica's pharmacological mechanism for treating ischemic stroke, highlighting its potential as a therapeutic option for brain damage by regulating inflammatory responses.
Brucine, a component of Strychnos nux-vomica with potential anti-tumor and anti-inflammatory effects, is limited by its toxicity, especially in the central nervous system. This study found that brucine induces death in nerve cells and astrocytes, and triggers a pathway involving PPARγ/NF-κB/caspase 3-dependent apoptosis. Brucine directly bound to caspase 3, and a caspase 3 inhibitor abolished the neurotoxicity. These findings provide insight into the toxicity mechanism of brucine and suggest a potential strategy for addressing it.
Researchers developed a COVID-19 mini-repertory/app based on various data collections and tested it. This involved combining information on the disease's symptoms and proposed remedies, using a Bayesian approach. The app aims to assist in treatment decisions for COVID-19 patients.
Researchers have developed a natural product-based drug to combat COVID-19 by targeting the key component involved in viral replication, the SARS-CoV-2 main protease (M). Phytochemicals from natural products were screened for drug likeness analysis and binding site-specific consensus-based molecular docking studies were carried out. The top compounds were tested for ADME-Tox properties and antiviral activity. Further molecular dynamics simulations and binding affinity estimation revealed that two analogues, demethoxyguiaflavine and strychnoflavine, have potential against M and can be validated through clinical studies. This study offers a potential solution for COVID-19 treatment through the use of natural products.
This study sought to identify small molecules that could inhibit the replication of the SARS-CoV-2 virus. Using a high-throughput screening approach, the researchers identified two compounds that were effective in stopping the virus from replicating in cells. Further experiments revealed that the compounds worked by targeting the virus's RNA polymerase, a key enzyme involved in replication. These findings provide promising leads for the development of new therapies to combat SARS-CoV-2 infection, and also highlight the potential of high-throughput screening as a tool for drug discovery.