Swertia chirayita

Ethnobotanical Studies

Studies

A novel bellidifolin intervention mitigates nonalcoholic fatty liver disease-like changes induced by bisphenol F.

Xue J et al (2024).
J Biomed Res.
DOI:
10.7555/JBR.37.20230169
PubMed:
38808572

A Comparative In Vitro Analysis of Antimicrobial Effectiveness and Compressive Resilience in Chirata and Terminalia arjuna Modified Glass Ionomer Cement.

Summary

Scientists studied the use of Chirayita and T. arjuna extracts to improve the antibacterial properties of glass ionomer cement used in dental restorations. This could potentially reduce the risk of cavity-causing microorganism growth.

Antimicrobial
Devi K et al (2024).
Cureus.
DOI:
10.7759/cureus.52198
PubMed:
38347981

Biochemical characterization of bioinspired nanosuspensions from Swertia chirayita extract and their therapeutic effects through nanotechnology approach.

Raza A et al (2024).
PLoS One.
DOI:
10.1371/journal.pone.0293116
PubMed:
38330034

Neuroprotective Effects of Isolated Mangiferin from Swertia chirayita Leaves Regulating Oxidative Pathway on Streptozotocin-Induced Diabetic Neuropathy in Experimental Rats.

Summary

Researchers investigated the potential of Swertia chirayita, a plant with anti-inflammatory and antioxidant properties, to help with diabetic peripheral neuropathy (DPN), a complication of diabetes. Assessing oxidative stress's role in DPN is important for understanding and treating the condition.

DiabetesNeuroscience
Shivam and Gupta AK (2024).
Cent Nerv Syst Agents Med Chem.
DOI:
10.2174/0118715249255977231213053039
PubMed:
38305392

Metabolomics-based pharmaceutical evaluation of different parts of Swertia chirayita (Roxb.) Buch.-Ham. ex C.B. Clarke from the western Himalayas.

Tewari D et al (2024).
J Sep Sci.
DOI:
10.1002/jssc.202300795
PubMed:
38234031

Ethnopharmacologically important highly subsidized Indian medicinal plants: Systematic review on their traditional uses, phytochemistry, pharmacology, quality control, conservation status and future prospective.

Summary

This review provides updated information on thirteen medicinal plants prioritized by the Indian government. It covers traditional uses, phytochemistry, pharmacology, quality control, and conservation status. Useful for understanding their importance and developing conservation strategies.

Review Phytochemistry
Anmol et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117385
PubMed:
37951375

Automated Composition Assessment of Natural Extracts: Untargeted Mass Spectrometry-Based Metabolite Profiling Integrating Semiquantitative Detection.

Rutz A and Wolfender JL (2023).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.3c03099
PubMed:
37949451

Toxicological Assessment and Anti-diabetic Effects of Combined Extract of Chirata, Fenugreek and Sesame on Regulating TNF-α, TGF-β and Oxidative Stress in Streptozotocin Induced Diabetic Rats.

Summary

Researchers investigated the potential of Swertia chirayita, Trigonella foenum-gracum, and Sesamum indicum in treating diabetes. Understanding the role of innate immunity and inflammation in diabetes-related microvascular problems is crucial.

DiabetesImmunology
Shivam and Gupta AK (2023).
Curr Drug Discov Technol.
DOI:
10.2174/0115701638252203230919092315
PubMed:
37870057

Protection of Oxygen Glucose Deprivation-Induced Human Brain Vascular Pericyte Injury: Beneficial Effects of Bellidifolin in Cellular Pyroptosis.

Summary

Pericytes help maintain brain vascular health, but their role in ischemic stroke injury is unclear. Inflammation worsens stroke damage, but this study found that an immortalized human brain pericyte cell line challenged with oxygen and glucose deprivation resulted in inflammation triggered by the NLRP3 inflammasome and pyroptosis. The protein gasdermin D (GSDMD) was involved, and a compound derived from Tibetan medicine, bellidifolin, showed promise in reducing inflammasome formation and protecting against pyroptosis. These findings offer new therapeutic avenues for stroke treatment.

Neuroscience
An D et al (2023).
Neurochem Res.
DOI:
10.1007/s11064-023-03943-7
PubMed:
37127800

Molecular recognition of bio-active triterpenoids from Swertia chirayita towards hepatitis Delta antigen: a mechanism through docking, dynamics simulation, Gibbs free energy landscape.

Moharana M, Pattanayak SK and Khan F (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2184173
PubMed:
36856037

Artificial seed production and cryopreservation by encapsulation dehydration for medicinal herb of himalayan region, Swertia chirayita.

Gupta R and Sood H (2022).
Cryo Letters.
PubMed:
36626135

Optimizing nutrient media conditions for continuous production of shoot biomass enriched in major medicinal constituents, amarogentin and mangiferin of endangered medicinal herb, Swertia chirayita.

Gupta R and Sood H (2022).
Vegetos.
DOI:
10.1007/s42535-022-00464-6
PubMed:
36061345

A New RP-HPLC Method for Simultaneous Determination of Amaroswerin, Amarogentin and Andrographolide in a Herbal Drug "Chirayata".

Sharma YP et al (2022).
J Chromatogr Sci.
DOI:
10.1093/chromsci/bmac018
PubMed:
35253055

Cytotoxic Potential of Biogenic Zinc Oxide Nanoparticles Synthesized From Swertia chirayita Leaf Extract on Colorectal Cancer Cells.

Cancer
Berehu HM et al (2021).
Front Bioeng Biotechnol.
DOI:
10.3389/fbioe.2021.788527
PubMed:
34976976

Swertia chirayita suppresses the growth of non-small cell lung cancer A549 cells and concomitantly induces apoptosis via downregulation of JAK1/STAT3 pathway.

Immunology
Ahmad A et al (2021).
Saudi J Biol Sci.
DOI:
10.1016/j.sjbs.2021.06.085
PubMed:
34764752

Swertia purpurascens Wall ethanolic extract mitigates hepatic fibrosis and restores hepatic hepcidin levels via inhibition of TGFβ/SMAD/NFκB signaling in rats.

Raj D et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2021.114741
PubMed:
34699946

Correction to: Bioactivities of Penicillium citrinum isolated from a medicinal plant Swertia chirayita.

Sharma H et al (2021).
Arch Microbiol.
DOI:
10.1007/s00203-021-02546-6
PubMed:
34453558

Bioactivites of Penicillium citrinum isolated from a medicinal plant Swertia chirayita.

Sharma H et al (2021).
Arch Microbiol.
DOI:
10.1007/s00203-021-02498-x
PubMed:
34338823

Natural plant products as potential inhibitors of RNA dependent RNA polymerase of Severe Acute Respiratory Syndrome Coronavirus-2.

Summary

Researchers investigated the interaction between phytochemicals from Indian medicinal plants and the RNA-dependent RNA polymerase (RdRP) of SARS-CoV-2. Using molecular docking and dynamics simulations, they identified four top phytochemicals, including cordifolide A and sitoindoside IX, which showed strong binding to RdRP and may serve as potential inhibitors. The study suggests that drug repurposing efforts can target RdRP inhibition and that natural compounds may hold promise as a treatment for COVID-19.

COVID-19Genetics
Koulgi S et al (2021).
PLoS One.
DOI:
10.1371/journal.pone.0251801
PubMed:
33984041

Utilization of Swertia chirayita Plant Extracts for Management of Diabetes and Associated Disorders: Present Status, Future Prospects and Limitations.

Review Diabetes
Dey P et al (2020).
Nat Prod Bioprospect.
DOI:
10.1007/s13659-020-00277-7
PubMed:
33118125

Ultra performance liquid chromatography coupled with principal component and cluster analysis of Swertia chirayita for adulteration check.

Phytochemistry
Singh M et al (2019).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2018.10.054
PubMed:
30412803

Production from both wild harvest and cultivation: The cross-border Swertia chirayita (Gentianaceae) trade.

Review
Cunningham AB et al (2018).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2018.06.033
PubMed:
29960022

A Review of Swertia chirayita (Gentianaceae) as a Traditional Medicinal Plant.

Review
Kumar V and Van Staden J (2016).
Front Pharmacol.
DOI:
10.3389/fphar.2015.00308
PubMed:
26793105

Evaluation of antioxidant, antibacterial, and antidiabetic potential of two traditional medicinal plants of India: Swertia cordata and Swertia chirayita.

Diabetes
Roy P et al (2015).
Pharmacognosy Res.
DOI:
10.4103/0974-8490.157997
PubMed:
26109789

Metabolic discrimination of Swertia mussotii and Swertia chirayita known as "Zangyinchen" in traditional Tibetan medicine by (1)H NMR-based metabolomics.

Phytochemistry
Fan G et al (2014).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2014.06.014
PubMed:
24992216

In vitro and in vivo antioxidant effects of the ethanolic extract of Swertia chirayita.

Chen Y et al (2011).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2011.04.058
PubMed:
21549823