Symphytum officinale

Common Names: common comfrey

Ethnobotanical Studies

Studies

[Screening and Stress Responsive Characteristics of Potential Hyperaccumulator of Pb, Zn, and Cd Compound Heavy Metals].

Fan SX et al (2024).
Huan Jing Ke Xue.
DOI:
10.13227/j.hjkx.202308262
PubMed:
39168703

GLDA exhibits advantages in the phytoextraction of Cd and Ni in land-applied municipal sludge.

Wu J et al (2024).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-024-34657-0
PubMed:
39134793

Seeing double: two different homospermidine oxidases are involved in pyrrolizidine alkaloid biosynthesis in different organs of comfrey (Symphytum officinale).

Phytochemistry
Zakaria MM et al (2024).
Plant J.
DOI:
10.1111/tpj.16847
PubMed:
38815125

Transcriptomic and physiological analyses of Symphytum officinale L. in response to multiple heavy metal stress.

Xu YF et al (2024).
Ecotoxicol Environ Saf.
DOI:
10.1016/j.ecoenv.2024.116361
PubMed:
38663189

Cadmium/zinc stresses and plant cultivation influenced soil microflora: a pot experiment conducted in field.

Guo D et al (2024).
Ecotoxicol Environ Saf.
DOI:
10.1016/j.ecoenv.2024.116384
PubMed:
38657451

Potential of Plant-Based Extracts to Alleviate Sorbitol-Induced Osmotic Stress in Cabbage Seedlings.

Pacyga K et al (2024).
Plants (Basel).
DOI:
10.3390/plants13060843
PubMed:
38592867

Effects of Different Heavy Metal Stressors on the Endophytic Community Composition and Diversity of Symphytum officinale.

Ma J et al (2024).
Microorganisms.
DOI:
10.3390/microorganisms12030477
PubMed:
38543528

Healing of Skin Wounds in Rats Using Creams Based on Symphytum Officinale Extract.

Mârza SM et al (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25063099
PubMed:
38542069

Effect of robbing intensity on reproductive success of Symphytum officinale (Boraginaceae).

Ehmet N et al (2024).
J Plant Res.
DOI:
10.1007/s10265-024-01536-1
PubMed:
38506958

Phytochemical profiling and bioactivity assessment of underutilized Symphytum species in comparison with Symphytum officinale.

Phytochemistry
Luca SV et al (2024).
J Sci Food Agric.
DOI:
10.1002/jsfa.13279
PubMed:
38252561

Metronidazole Potentiation by Panax Ginseng and Symphytum officinale: A New Strategy for P. gingivalis Infection Control.

Ibrahim SM, Al-Mizraqchi AS and Haider J (2023).
Antibiotics (Basel).
DOI:
10.3390/antibiotics12081288
PubMed:
37627708

Artemisia abrotanum and Symphytum officinale Polyphenolic Compounds-Rich Extracts with Potential Application in Diabetes Management.

Diabetes
Neagu E et al (2023).
Metabolites.
DOI:
10.3390/metabo13030354
PubMed:
36984794

Detoxification of comfrey (Symphytum officinale L.) extract using natural deep eutectic solvent (NADES) and evaluation of its anti-inflammatory, antioxidant, and hepatoprotective properties.

Immunology
Syarifah AN et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1012716
PubMed:
36937831

Traditional Plants Used in Southern Brazil as a Source to Wound Healing Therapies.

Review
Antonio Pereira I et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202201021
PubMed:
36703603

Morphological, ecological and geographic differences between diploids and tetraploids of Symphytum officinale (Boraginaceae) justify both cytotypes as separate species.

Genetics
Kobrlová L, Duchoslav M and Hroneš M (2022).
AoB Plants.
DOI:
10.1093/aobpla/plac028
PubMed:
35874916

Remediation of atmospheric sulfur and ammonia by wetland plants: development of a study method.

Kanté M, Lemauviel-Lavenant S and Cliquet JB (2022).
Int J Phytoremediation.
DOI:
10.1080/15226514.2021.1949264
PubMed:
35180015

The Effect of Comfrey on Enoxaparin-Induced Bruise in Patients with Acute Coronary Syndrome: A Randomised Clinical Trial.

Bagheri Z et al (2021).
J Pharmacopuncture.
DOI:
10.3831/KPI.2021.24.4.196
PubMed:
35028171

Honeybees with extensive foraging experience rob nectar more frequently.

Nagano Y and Yokoi T (2021).
Naturwissenschaften.
DOI:
10.1007/s00114-021-01781-7
PubMed:
34958410

Streptomyces pactum and Bacillus consortium influenced the bioavailability of toxic metals, soil health, and growth attributes of Symphytum officinale in smelter/mining polluted soil.

Ali A et al (2021).
Environ Pollut.
DOI:
10.1016/j.envpol.2021.118237
PubMed:
34592330

Corolla Abscission Triggered by Nectar Robbers Positively Affects Reproduction by Enhancing Self-Pollination in Symphytum officinale (Boraginaceae).

Hou QZ et al (2021).
Biology (Basel).
DOI:
10.3390/biology10090903
PubMed:
34571781

Bacillus subtilis and saponin shifted the availability of heavy metals, health indicators of smelter contaminated soil, and the physiological indicators of Symphytum officinale.

Phytochemistry
Li Y et al (2021).
Chemosphere.
DOI:
10.1016/j.chemosphere.2021.131454
PubMed:
34271464

Support for Regulatory Assessment of Percutaneous Absorption of Retronecine-type Pyrrolizidine Alkaloids through Human Skin.

Phytochemistry
Plaza A et al (2022).
Planta Med.
DOI:
10.1055/a-1505-8524
PubMed:
34116569

Symphytum officinale L.: Liquid-liquid chromatography isolation of caffeic acid oligomers and evaluation of their influence on pro-inflammatory cytokine release in LPS-stimulated neutrophils.

ImmunologyPhytochemistry
Trifan A et al (2020).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2020.113169
PubMed:
32739565

TLC-densitometric analysis of allantoin in Symphytum officinale L. roots.

Kimel K et al (2020).
Acta Pharm.
DOI:
10.2478/acph-2020-0014
PubMed:
31677368

Symphytum officinale augments osteogenesis in human bone marrow-derived mesenchymal stem cells in vitro as they differentiate into osteoblasts.

Genetics
Dey D et al (2020).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2019.112329
PubMed:
31672526

A Symphytum officinale Root Extract Exerts Anti-inflammatory Properties by Affecting Two Distinct Steps of NF-κB Signaling.

Immunology
Seigner J et al (2019).
Front Pharmacol.
DOI:
10.3389/fphar.2019.00289
PubMed:
31105555

Comfrey.

Review
(2021).
PubMed:
30000832

Herbal Supplements and Hepatotoxicity: A Short Review.

Review
Haslan H, Suhaimi FH and Das S (2015).
Nat Prod Commun.
PubMed:
26669124

Herbal medicine for low-back pain.

Summary

This review analyzes the use of herbal medicines for treating chronic low-back pain. Understanding their effectiveness can help inform treatment choices for patients seeking alternative pain relief options.

Meta-Analysis Pain
Oltean H et al (2014).
Cochrane Database Syst Rev.
DOI:
10.1002/14651858.CD004504.pub4
PubMed:
25536022

Botanical briefs: comfrey (Symphytum officinale).

Horinouchi CD and Otuki MF (2013).
Cutis.
PubMed:
23772427

[Pharmaceutical sheet. Symphytum officinale L., dermal use (Flexagile cream)].

Review
Tanret I and Duh D (2012).
J Pharm Belg.
PubMed:
22536684