Syzygium aromaticum

Common Names: clove

Ethnobotanical Studies

Studies

Insights into the flavor endowment of aroma-active compounds in cloves (Syzygium aromaticum) to stewed beef.

Qiang Y et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.140704
PubMed:
39226642

Phytochemical profiling and evaluation of antimicrobial activities of common culinary spices: Syzygium aromaticum (clove) and Piper nigrum (black pepper).

Summary

Researchers studied clove and black pepper extracts for their potential as alternative antimicrobial agents due to increasing antibiotic resistance. The extracts have a history of traditional medicinal and culinary use.

AntimicrobialPhytochemistry
Zhao K et al (2024).
Front Nutr.
DOI:
10.3389/fnut.2024.1447144
PubMed:
39211834

Synthesis of Silver Nanoparticles Using Azadirachta indica and Syzygium aromaticum Extract and Its Antibacterial Action Against Enterococcus faecalis: An In Vitro Study.

Chandran N, Ramesh S and Shanmugam R (2024).
Cureus.
DOI:
10.7759/cureus.65044
PubMed:
39165463

Exploring the anti-protozoal mechanisms of Syzygium aromaticum phytochemicals targeting Cryptosporidium parvum lactate dehydrogenase through molecular dynamics simulations.

Altwaim SA et al (2024).
Arch Biochem Biophys.
DOI:
10.1016/j.abb.2024.110124
PubMed:
39154815

Phytochemicals-linked food safety and human health protective benefits of the selected food-based botanicals.

Christopher A and Shetty K (2024).
PLoS One.
DOI:
10.1371/journal.pone.0307807
PubMed:
39074098

Exogenously applied nano-zinc oxide mitigates cadmium stress in Zea mays L. through modulation of physiochemical activities and nutrients homeostasis.

Ahmed S et al (2024).
Int J Phytoremediation.
DOI:
10.1080/15226514.2024.2383657
PubMed:
39066663

Synthesis and characterization of nano-biopolymer carriers loaded with clove (Syzygium aromaticum L.) extract as an anticancer agent: an in vitro study.

Cancer
Ansari M et al (2024).
J Biomater Sci Polym Ed.
DOI:
10.1080/09205063.2024.2381372
PubMed:
39058583

Synergistic Interaction of Certain Essential Oils and Their Active Compounds with Fluconazole against Azole-resistant Strains of Cryptococcus neoformans.

Khan MSA et al (2024).
Ann Afr Med.
DOI:
10.4103/aam.aam_197_23
PubMed:
39034564

Inhibitory activities of essential oils from Syzygium aromaticum inhibition of Echinochloa crus-galli.

Ni X et al (2024).
PLoS One.
DOI:
10.1371/journal.pone.0304863
PubMed:
38905259

Stress-Relieving Properties of a Polyherbal Blend with Syzygium aromaticum L. and Coffea canephora Pierre ex A. Froehner: A Review and Bibliometric Analysis.

Review
Zakaria N et al (2024).
World J Biol Psychiatry.
DOI:
10.1080/15622975.2024.2369329
PubMed:
38900601

Effectiveness of some plant extracts in biocontrol of induced onion basal rot disease in greenhouse conditions.

Hegazy MGA et al (2024).
AMB Express.
DOI:
10.1186/s13568-024-01721-4
PubMed:
38874641

Attitude and Practice of Pharmacy Students Toward Traditional Herbal Medicines, Sudan.

Mahmoud EI, Yousif MA and Arbab AH (2024).
Integr Pharm Res Pract.
DOI:
10.2147/IPRP.S465056
PubMed:
38827648

Studies on the mechanisms of Helicobacter pylori inhibition by Syzygium aromaticum aqueous extract.

Peng C et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155540
PubMed:
38810548

Safety and efficacy of a feed additive consisting of a tincture derived from the flowers of Syzygium aromaticum (L.) Merr. & L.M. Perry (clove tincture) for all animal species (FEFANA asbl).

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) et al (2024).
EFSA J.
DOI:
10.2903/j.efsa.2024.8791
PubMed:
38756347

Nanostructured lipid carriers loaded with essential oils: a strategy against SARS-CoV-2.

Summary

NLCs loaded with essential oils inhibit SARS-CoV-2, with promising results exceeding 2-log reduction in virion count. Innovative strategy for combating SARS-CoV-2.

COVID-19
Almeida LF et al (2024).
J Microencapsul.
DOI:
10.1080/02652048.2024.2348463
PubMed:
38686964

Eugenol Inhibits Neutrophils Myeloperoxidase In Vitro and Attenuates LPS-Induced Lung Inflammation in Mice.

Summary

Eugenol from clove oil reduces lung inflammation in mouse model by inhibiting neutrophil activity and metalloproteinases. Potential treatment for lung diseases.

Immunology
Chniguir A et al (2024).
Pharmaceuticals (Basel).
DOI:
10.3390/ph17040504
PubMed:
38675465

Herbal Spices as Food and Medicine: Microscopic Authentication of Commercial Herbal Spices.

Khan A et al (2024).
Plants (Basel).
DOI:
10.3390/plants13081067
PubMed:
38674476

Clove Essential Oil: Chemical Profile, Biological Activities, Encapsulation Strategies, and Food Applications.

Summary

Clove essential oil (CEO) contains bioactive compounds with various health benefits, including antibacterial, antifungal, analgesic, antioxidant, anticancer, antiseptic, and anti-inflammatory properties. Encapsulation can improve CEO's stability for use in cosmetics, food, and medicine industries.

Review Phytochemistry
Liñán-Atero R et al (2024).
Antioxidants (Basel).
DOI:
10.3390/antiox13040488
PubMed:
38671935

Efficacy and Synergistic Potential of Cinnamon (Cinnamomum zeylanicum) and Clove (Syzygium aromaticum L. Merr. & Perry) Essential Oils to Control Food-Borne Pathogens in Fresh-Cut Fruits.

Iseppi R et al (2024).
Antibiotics (Basel).
DOI:
10.3390/antibiotics13040319
PubMed:
38666995

Insecticidal Activity of Essential Oils and Their Synergistic Effect on Improving the Efficacy of β-Cypermethrin against Blattella germanica.

Zhu J et al (2024).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.4c01345
PubMed:
38652776

In vivo determination of the anti-inflammatory and antioxidant effects of the aqueous extract of Syzygium aromaticum (clove) in an asthmatic rat model.

Summary

Study evaluated anti-inflammatory and antioxidant effects of clove extract on asthma in rats. AEC reduced lung oxidative stress and inflammation, showing potential for asthma treatment. Important for developing asthma therapies.

AsthmaImmunology
Ounaceur LS et al (2024).
Cell Mol Biol (Noisy-le-grand).
DOI:
10.14715/cmb/2024.70.3.5
PubMed:
38650159

Oleanolic acid: an antimycobacterial component of Syzygium aromaticum L. and inhibitor of efflux mediated drug resistance.

El Ghallab Y et al (2024).
Nat Prod Res.
DOI:
10.1080/14786419.2024.2343916
PubMed:
38635391

Pharmacological and immunomodulatory modes of action of medically important phytochemicals against arthritis: A molecular insight.

Summary

Study finds potential benefits of medicinal plants like Curcuma longa, Syzygium aromaticum, and Zingiber officinale in treating rheumatoid arthritis due to antioxidant and anti-inflammatory properties, offering safer alternative to conventional treatments.

Review ArthritisImmunology
Aqsa et al (2024).
Mol Biol Rep.
DOI:
10.1007/s11033-024-09386-9
PubMed:
38536526

Artificial Biosynthetic Pathway for Efficient Synthesis of Vanillin, a Feruloyl-CoA-Derived Natural Product from Eugenol.

Zhu X et al (2024).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.3c08723
PubMed:
38501643

Formulation and Development of a Herbal Antifungal Gel Containing Origanum vulgare and Syzygium aromaticum Essential Oils Against Oral Candida albicans.

Summary

Researchers formulated an antifungal gel containing oregano and clove oils to treat oral candidiasis effectively at lower concentrations, reducing side effects and resistance. Gel showed no cytotoxicity, offering a safe treatment option.

Antimicrobial
Jayasankar P et al (2024).
Cureus.
DOI:
10.7759/cureus.54348
PubMed:
38500909

Antimicrobial Activity of Syzygium aromaticum Essential Oil in Human Health Treatment.

Summary

Researchers investigated the potential of clove essential oil to combat drug-resistant infections. The oil has various beneficial properties including antioxidant, antimicrobial, and anti-inflammatory effects. This study could guide future therapeutic approaches for infectious diseases caused by drug-resistant microorganisms.

Review AntimicrobialPhytochemistry
Maggini V et al (2024).
Molecules.
DOI:
10.3390/molecules29050999
PubMed:
38474510

Using Essential Oils to Reduce Yersinia enterocolitica in Minced Meat and in Biofilms.

Vidaković Knežević S et al (2024).
Foods.
DOI:
10.3390/foods13050806
PubMed:
38472919

Plant extract mediated synthesis of ZnO and CeO(2) nanoparticles for spectrofluorometric assay of omeprazole and domperidone in pharmaceuticals.

Alarfaj NA et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e26164
PubMed:
38390119

An integrated in vitro approach on the enzymatic and antioxidant mechanisms of four commercially available essential oils (Copaifera officinalis, Gaultheria fragrantissima, Helichrysum italicum, and Syzygium aromaticum) traditionally used topically for their anti-inflammatory effects.

Immunology
Cebollada P et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1310439
PubMed:
38371914

Eugenol Reduced ΜPO, CD45 and HMGB1 Expression and Attenuated the Expression of Leukocyte Infiltration Markers in the Intestinal Tissue in Biliopancreatic Duct Ligation-Induced Pancreatitis in Rats.

Gastroenterology
Oikonomou P et al (2023).
Medicina (Kaunas).
DOI:
10.3390/medicina60010074
PubMed:
38256335

Green Synthesis of Selenium, Zinc Oxide, and Strontium Nanoparticles and Their Antioxidant Activity - A Comparative In Vitro Study.

Immunology
Shanmugam R et al (2023).
Cureus.
DOI:
10.7759/cureus.50861
PubMed:
38249274

Antifungal Activity of Thirty Essential Oils to Control Pathogenic Fungi of Postharvest Decay.

Summary

This study evaluated the inhibitory effects of 30 essential oils (EOs) on the growth of fungal pathogens in crops. The EOs showed promising results in completely inhibiting the growth of some fungi and significantly reducing the growth of others. More research is needed to confirm these findings in real-life settings.

Antimicrobial
Allagui MB, Moumni M and Romanazzi G (2023).
Antibiotics (Basel).
DOI:
10.3390/antibiotics13010028
PubMed:
38247587

Preparation of bioactive film based on chitosan and essential oils mixture for enhanced preservation of food products.

Mouhoub A et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.129396
PubMed:
38219942

Insights into the mechanisms of diabetic wounds: pathophysiology, molecular targets, and treatment strategies through conventional and alternative therapies.

Summary

Plants and their active constituents can potentially treat diabetic foot syndrome, promoting wound healing, reducing inflammation, and stimulating angiogenesis. These alternatives could decrease amputations and offer affordable options. Further research is needed for a better understanding.

Review Diabetes
Yadav JP et al (2024).
Inflammopharmacology.
DOI:
10.1007/s10787-023-01407-6
PubMed:
38212535

Pharmacodynamic, pharmacokinetic, toxicity, and recent advances in Eugenol's potential benefits against natural and chemical noxious agents: A mechanistic review.

Review
Tavvabi-Kashani N et al (2024).
Toxicon.
DOI:
10.1016/j.toxicon.2024.107607
PubMed:
38191032

Bioactive properties of clove (Syzygium aromaticum) essential oil nanoemulsion: A comprehensive review.

Summary

Clove essential oil, rich in bioactive compounds, has antibacterial, antifungal, and anti-inflammatory properties. It can be used as a natural remedy for toothaches and gum discomfort, and has potential applications in food processing.

Review Phytochemistry
Pandey VK et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e22437
PubMed:
38163240

Insecticidal plants as trade opportunities and use by small vegetable producers: an example using essential oils to control Diaphania hyalinata (Lepidoptera: Crambidae).

Silva IMD et al (2023).
An Acad Bras Cienc.
DOI:
10.1590/0001-3765202320191305
PubMed:
38126611

Systematic analysis of antimicrobial activity, phytochemistry, and in silico molecular interaction of selected essential oils and their formulations from different Indian spices against foodborne bacteria.

Summary

Indian spice essential oils such as cardamom, clove, cinnamon, and bay leaves exhibit antibacterial properties, with cinnamon and a cardamom-cinnamon blend being the most effective. Cinnamon oil's active compounds bind to bacterial proteins, increasing susceptibility to the oil, making these oils potential weapons against foodborne pathogens.

AntimicrobialPhytochemistry
Gupta N et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e22480
PubMed:
38107328

Assessment of Antimicrobial Activity and Cytotoxic Effect of Nigella sativa, Syzygium aromaticum, and Allium cepa Formulation for Use As Antimicrobial Gel or Mouthwash.

Summary

Researchers studied the combined effects of black cumin, clove, and onion extracts and found that they possess various medicinal properties. This combination could be beneficial for therapeutic purposes.

Antimicrobial
Begum NF et al (2023).
Cureus.
DOI:
10.7759/cureus.48549
PubMed:
38074008

Phytogenics in Ginger, Origanum vulgare, and Syzygium aromaticum and Their Potential as a Feed Additive against Clostridium perfringens in Broiler Production.

Review
Valdez G et al (2023).
Animals (Basel).
DOI:
10.3390/ani13233643
PubMed:
38066994

Efficacy and toxicity of different plant extracts over the period of time in Bracon hebetor (Say) (Hymenoptera: Braconidae).

Asrar M et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e21631
PubMed:
38027796

Influence of nano-formulations of clove bud (Syzygium aromaticum) extract on freezing ability, antioxidant capacity, caspase-3 activity, acrosome reaction and fertility of frozen rabbit semen.

Immunology
Khalil WA et al (2023).
Reprod Domest Anim.
DOI:
10.1111/rda.14511
PubMed:
38018440

Enhancing wool dyeing with clove bud (Syzygium aromaticum) based natural dye via microwave treatment using a central composite design.

Yameen M et al (2023).
Sci Prog.
DOI:
10.1177/00368504231215593
PubMed:
37993993

Synergistic Antimicrobial Activity of Eugenol in Combination with Fosfomycin to Combat Escherichia coli and Potential Effect on Plasmid-Mediated Fosfomycin Resistance Genes.

Summary

This study found that a combination of Eugenol (from Syzygium aromaticum) and Fosfomycin could effectively inhibit multidrug-resistant Uropathogenic Escherichia coli. The genes fosA3 and fosA4, which contribute to Fosfomycin resistance, were present in a small percentage of isolates. These findings suggest a potential new treatment for bacterial infections.

AntimicrobialGenetics
Ibrahim AA and Mohammed RK (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202301567
PubMed:
37956152

In Vitro Antioxidant and Inhibitory Study of Picrorhiza kurroa (Kutki), Syzygium aromaticum (Loung), Lawsonia inermis (Henna), Rheum emodi (Revand Chini), Curcuma longa (Haldi) Against Lipid Per-Oxidation in Mice Brain and Liver.

Summary

This study evaluated the antioxidant and protective properties of certain medicinal plants against oxidative stress in the brain and liver. , , and showed strong effects and could potentially help manage or prevent degenerative diseases.

ImmunologyNeuroscience
Hassan F et al (2023).
Dose Response.
DOI:
10.1177/15593258231210431
PubMed:
37900620

The Antifungal Activities of Syzygium aromaticum and Alpinia purpurata Extracts Against Candida krusei: Bioactivity Tests, Molecular Modeling, and Toxicity Tests.

Summary

Researchers found that extracts from Syzygium aromaticum and Alpinia purpurata can be used as alternative drugs to treat Candida krusei infections, which are highly lethal and resistant to fluconazole treatment. This offers potential new treatment options for combating this deadly fungal infection.

Antimicrobial
Aisy DUR et al (2023).
Asian Pac J Cancer Prev.
DOI:
10.31557/APJCP.2023.24.10.3403
PubMed:
37898844

Chromosome-scale assemblies of S. malaccense, S. aqueum, S. jambos, and S. syzygioides provide insights into the evolution of Syzygium genomes.

Genetics
Ouadi S et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1248780
PubMed:
37868305

Synergistic combination of Cinnamomum verum and Syzygium aromaticum treatment for cutaneous leishmaniasis and investigation of their molecular mechanism of action.

Essid R et al (2023).
Int J Environ Health Res.
DOI:
10.1080/09603123.2023.2267470
PubMed:
37855230

Neuroprotective effects of a combination of Boswellia papyrifera and Syzygium aromaticum on AlCl3 induced Alzheimer's disease in male albino rat.

Summary

Combination therapy of Boswellia papyrifera and Syzygium aromaticum improved cognitive function, increased acetylcholinesterase and oxidative enzyme levels, and reduced oxidative stress markers in Alzheimer's disease, offering potential treatment.

Neuroscience
Aljarari RM et al (2023).
Braz J Biol.
DOI:
10.1590/1519-6984.272466
PubMed:
37851769

Phytochemical Composition and Pharmacological Activities of Three Essential Oils Collected from Eastern Morocco (Origanum compactum, Salvia officinalis, and Syzygium aromaticum): A Comparative Study.

Summary

A study investigated the properties of three essential oils, finding differences in compounds, strong antioxidant activity in one, and impressive antifungal activity in another. Computational methods were used to examine compound-protein interactions.

Phytochemistry
Loukili EH et al (2023).
Plants (Basel).
DOI:
10.3390/plants12193376
PubMed:
37836118

Extending shelf life and optimizing effective parameters by using clove oil (Syzygium aromaticum oleum)/orange oil (Citrus aurantium var dulcis oleum) in bread: thermal, morphological and sensory approach.

Şahin Fİ and Acaralı N (2023).
J Food Sci Technol.
DOI:
10.1007/s13197-023-05827-8
PubMed:
37786596

Bioactivity of the Ethanol Extract of Clove (Syzygium aromaticum) as Antitoxin.

Afrendi E et al (2023).
Int J Food Sci.
DOI:
10.1155/2023/3245210
PubMed:
37780095

Anti-oomycete activities from essential oils and their major compounds on Phytophthora infestans.

Deweer C, Sahmer K and Muchembled J (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-023-29270-6
PubMed:
37779122

Plant derived active compounds of ayurvedic neurological formulation, Saraswatharishta as a potential dual leucine zipper kinase inhibitor: an in-silico study.

Koirala S et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2260892
PubMed:
37771163

Investigating the Therapeutic Potential of Plants and Plant-Based Medicines: Relevance to Antioxidant and Neuroprotective Effects.

Summary

Various plant extracts were examined for their ability to reduce oxidative stress in brain cells. Elderberry, Queen Garnet plum, and clove showed neuroprotective effects, while elderberry also demonstrated treatment effects. Further research is needed to explore their potential as therapies for oxidative stress-related disorders.

ImmunologyNeuroscience
May N et al (2023).
Nutrients.
DOI:
10.3390/nu15183912
PubMed:
37764696

Detection of hemolytic Shiga toxin-producing Escherichia coli in fresh vegetables and efficiency of phytogenically synthesized silver nanoparticles by Syzygium aromaticum extract and gamma radiation against isolated pathogens.

El-Bastawisy HS, El-Sayyad GS and Abu Safe FA (2023).
BMC Microbiol.
DOI:
10.1186/s12866-023-02994-8
PubMed:
37723460

Clove Buds Volatile Compounds: Inhibitory Activity on Mycobacterium Growth and Molecular Docking on Mmr Efflux Pump Drug Resistance.

El Ghallab Y et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202300895
PubMed:
37696771

Bioinspired palladium-doped manganese oxide nanocorns: a remarkable antimicrobial agent targeting phyto/animal pathogens.

Summary

Palladium-doped manganese oxide nanoparticles synthesized using a natural extract show strong antimicrobial activity, offering a potential eco-friendly solution to combat microbial pathogens.

Antimicrobial
Vikal S et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-40822-1
PubMed:
37640751

Linking traditional medicine to modern phytotherapy: Chemical characterization and assessment of antioxidant and anticholinesterase effects in vitro of a natural Persian remedy for dementia.

Summary

An improved formulation from Traditional Persian Medicine (TPM) containing a mixture of plants exhibits antioxidant and anti-cholinesterase properties, potentially making it a useful natural remedy for dementia. Further studies are needed for safety and efficacy.

ImmunologyNeuroscience
Peron G et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115674
PubMed:
37634357

Therapeutic Potential of Syzygium aromaticum in Gut Dysbiosis via TMAO Associated Diabetic Cardiomyopathy.

Summary

Gut bacteria imbalance causes intestinal and other diseases. Specific metabolites (like bile acids and trimethylamine) play a role. Elevated levels of oxidized trimethylamine link to cardiovascular disease. Herbal medicines and prebiotics could help restore balance and improve health.

CardiologyDiabetesGastroenterology
Singhal S and Rani V (2023).
Cardiovasc Hematol Agents Med Chem.
DOI:
10.2174/1871525721666230822100142
PubMed:
37608671

Toxicity, repellency, and anti-cholinesterase activities of bioactive molecules from clove buds Syzygium aromaticum L. as an ecological alternative in the search for control Hyalomma scupense (Acari: Ixodidae).

Alimi D et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e18899
PubMed:
37600394

Antimicrobial, Antibiofilm, and Anticancer Activities of Syzygium aromaticum Essential Oil Nanoemulsion.

Summary

The study prepared clove oil nanoemulsion and emulsion, characterized them, and found that the nanoemulsion had antibacterial, antifungal, antibiofilm, and anticancer properties. More research is needed for in vivo applications.

AntimicrobialCancerPhytochemistry
Shehabeldine AM et al (2023).
Molecules.
DOI:
10.3390/molecules28155812
PubMed:
37570781

Proximate composition and mineral content of spices increasingly employed in the Mediterranean diet.

Al Dhaheri AS et al (2023).
J Nutr Sci.
DOI:
10.1017/jns.2023.52
PubMed:
37528827

Acaricidal and repellent activities of ethanol extracts of nine chinese medicinal herbs against Rhipicephalus microplus (Acari: Ixodidae).

Li D et al (2023).
Exp Appl Acarol.
DOI:
10.1007/s10493-023-00813-3
PubMed:
37522955

Safety and efficacy of feed additives consisting of essential oils derived from the flower buds or the leaves of Syzygium aromaticum (L.) Merr. & L.M. Perry (clove bud oil and clove leaf oils) for all animal species (FEFANA asbl).

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) et al (2023).
EFSA J.
DOI:
10.2903/j.efsa.2023.8183
PubMed:
37522096

Control of Listeria monocytogenes in a fresh cheese using aromatic and medicinal plants and enterocin: a comparative study.

Ananou S et al (2023).
Lett Appl Microbiol.
DOI:
10.1093/lambio/ovad076
PubMed:
37401169

Determining the optimum mixture of three essential oils for potato sprout suppression at room temperature storage.

Thoma JL et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1199117
PubMed:
37389299

Eugenol relieves the pathological manifestations of Alzheimer's disease in 5×FAD mice.

Summary

Summary: Eugenol, a compound found in Syzygium aromaticum, has been found to have therapeutic effects in Alzheimer's disease (AD). AD is a neurodegenerative disease characterized by the buildup of amyloid-β and excessive neuroinflammation, leading to cognitive decline. Eugenol has shown neuroprotective and anti-inflammatory properties, making it a potential treatment option. This research highlights the importance of finding novel ways to combat AD and improve cognitive function.

Neuroscience
Jung MJ et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154930
PubMed:
37348246

The action of clove (Syzygium aromaticum ) and thyme ( Thymus vulgaris) essential oils in the control of Acanthhoscelides obtectus (Coleoptera: Chrysomelidae) in laboratory.

Mussalama AZ et al (2023).
An Acad Bras Cienc.
DOI:
10.1590/0001-3765202320201915
PubMed:
37341267

Valorization of clove (Syzygium aromaticum) by-products as potential stored grain protectants.

Bandara P and Senevirathne M (2023).
J Food Sci Technol.
DOI:
10.1007/s13197-023-05744-w
PubMed:
37273571

Feasibility study on the use of "Qi-tonifying medicine compound" as an anti-fatigue functional food ingredient based on network pharmacology and molecular docking.

Wu Y et al (2023).
Front Nutr.
DOI:
10.3389/fnut.2023.1131972
PubMed:
37215213

The Effects of Clove Oil on The Biochemical and Histological Parameters, and Autophagy Markers in Polycystic Ovary Syndrome-Model Rats.

Summary

Study investigated the effects of clove on PCOS rats. Results suggest that clove may have potential therapeutic benefits for PCOS.

Endocrinology
Soltani M et al (2023).
Int J Fertil Steril.
DOI:
10.22074/ijfs.2022.543640.1260
PubMed:
37183845

Multi-Targeting Neuroprotective Effects of Syzygium aromaticum Bud Extracts and Their Key Phytocompounds against Neurodegenerative Diseases.

Summary

The study investigated the neuroprotective properties of clove extract and its bioactive compounds on oxidative stress in human neuroblastoma cells. The extracts reduced reactive oxygen species, restored mitochondrial function, lowered lipid peroxidation, and displayed anti-acetylcholinesterase activity. Clove's multitarget approach may make it a potential candidate for developing Alzheimer's disease drugs as it could be a safer therapy capable of aiding multiple aspects of the disease, an area where current drugs struggle.

Neuroscience
Sharma H et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24098148
PubMed:
37175851

Novel Approach for a Controlled Delivery of Essential Oils during Long-Term Maize Storage: Clove Bud and Pennyroyal Oils Efficacy to Control Sitophilus zeamais, Reducing Grain Damage and Post-Harvest Losses.

Sousa PAS et al (2023).
Insects.
DOI:
10.3390/insects14040366
PubMed:
37103181

Antioxidant properties and cytotoxic effects of selected edible plants in Southeast Asia for further use as phytogenic antioxidant additives.

Immunology
Pasri P, Mermillod P and Khempaka S (2023).
Saudi J Biol Sci.
DOI:
10.1016/j.sjbs.2023.103631
PubMed:
37101816

Nutrient digestibility, gut microflora, carcass yield, and meat microbiology of broilers fed diets supplemented Ethiopian pepper (Xylopia aethiopica), cloves (Syzygium aromaticum), and their composite.

Gastroenterology
Williams GA et al (2023).
Trop Anim Health Prod.
DOI:
10.1007/s11250-023-03582-8
PubMed:
37084089

The Effects of Clove and Its Constituents on Reproductive System: a Comprehensive Review.

Review
Taghipour Z, Bahmanzadeh M and Rahimi R (2023).
Reprod Sci.
DOI:
10.1007/s43032-023-01223-x
PubMed:
37040058

Systematic review on the anxiolytic and hypnotic effects of flower extracts in in vivo pre-clinical studies published from 2010 to 2020.

Summary

Researchers conducted a systematic review of scientific articles published between 2010 and 2020 that evaluated the anxiolytic, sedative, and/or hypnotic effects of flower extracts in pre-clinical animal models. They found that some flower extracts have an anxiolytic effect comparable to diazepam, but their therapeutic utility in anxiety disorders needs more investigation. The study compiled the characteristics of anxiety studies in animal models, evaluated locomotor activity, and the hypnotic effect of the extracts. The study revealed that matricaria chamomilla had a sedative effect, and 23 other flower plants had anxiolytic effects. However, more reliable behavioral tests and better experimental designs are needed to obtain more conclusive evidence with clinical significance.

Review Neuroscience
Meneses C et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7830
PubMed:
37039741

Meta-Analysis of In Vitro Antimicrobial Capacity of Extracts and Essential Oils of Syzygium aromaticum, Citrus L. and Origanum L.: Contrasting the Results of Different Antimicrobial Susceptibility Methods.

Antimicrobial
Silva BN et al (2023).
Foods.
DOI:
10.3390/foods12061265
PubMed:
36981191

Bio-guided chemical characterization and nano-formulation studies of selected edible volatile oils with potentials antibacterial and anti-SARS-CoV-2 activities.

Summary

Selected essential oils (EOs) with promising antibacterial and antiviral properties against SARS-CoV-2 and bacteria were identified, along with suggested nano-emulsion dosage form. Mechanisms of antiviral activity were explored.

COVID-19
Refaey MS et al (2023).
Arab J Chem.
DOI:
10.1016/j.arabjc.2023.104813
PubMed:
36969951

Bioactivation of an orthodontic wire using multifunctional nanomaterials to prevent plaque accumulation.

Anand BG et al (2023).
Biomater Adv.
DOI:
10.1016/j.bioadv.2023.213346
PubMed:
36963344

Formulations of essential oils obtained from plants traditionally used as condiments or traditional medicine active against Staphylococcus aureus isolated from dairy cows with mastitis.

Phytochemistry
Albuquerque KRS et al (2023).
Lett Appl Microbiol.
DOI:
10.1093/lambio/ovad034
PubMed:
36918199

Potential use of essential oils from Origanum vulgare and Syzygium aromaticum to control Tetranychus urticae Koch (Acari: Tetranychidae) on two host plant species.

Phytochemistry
Susurluk H et al (2023).
PeerJ.
DOI:
10.7717/peerj.14475
PubMed:
36700001

HPLC/MS characterization of Syzygium aromaticum L. and evaluation of its effects on peritoneal adhesion: Investigating the role of inflammatory cytokines, oxidative factors, and fibrosis and angiogenesis biomarkers.

GeneticsImmunology
Moradi E et al (2023).
Physiol Rep.
DOI:
10.14814/phy2.15584
PubMed:
36695659

Silver Nanoparticles Phytofabricated through Azadirachta indica: Anticancer, Apoptotic, and Wound-Healing Properties.

Cancer
Dutt Y et al (2023).
Antibiotics (Basel).
DOI:
10.3390/antibiotics12010121
PubMed:
36671322

The potency of herbal extracts and its green synthesized nanoparticle formulation as antibacterial agents against Streptococcus mutans associated biofilms.

Karnjana K et al (2022).
Biotechnol Rep (Amst).
DOI:
10.1016/j.btre.2022.e00777
PubMed:
36582762

Chemical Profiles and Lethal Toxicities of Native Botanical Insecticides for the Control of Musca domestica Linnaeus and Stomoxys indicus Picard (Diptera: Muscidae) in Songkhla Province, Thailand.

Klakankhai W et al (2023).
J Econ Entomol.
DOI:
10.1093/jee/toac202
PubMed:
36545896

Bioaccumulation and emission of organophosphate esters in plants affecting the atmosphere's phosphorus cycle.

Long S et al (2023).
Environ Pollut.
DOI:
10.1016/j.envpol.2022.120803
PubMed:
36503012

Modulation of growth performance, gut morphometry, and cecal microbiota in broilers by clove (Syzygium aromaticum) and tulsi (Ocimum sanctum) supplementation.

Gastroenterology
Islam R et al (2023).
Poult Sci.
DOI:
10.1016/j.psj.2022.102266
PubMed:
36370662

Efficacy of Syzygium aromaticum essential oil on the growth and enzymatic activity of pathogenic Candida albicans strains.

Phytochemistry
Hekmatpanah A et al (2022).
Curr Med Mycol.
DOI:
10.18502/cmm.8.1.9209
PubMed:
36340432

Enhanced preservation effects of clove (Syzygium aromaticum) essential oil on the processing of Chinese bacon (preserved meat products) by beta cyclodextrin metal organic frameworks (β-CD-MOFs).

Phytochemistry
Wang Y et al (2023).
Meat Sci.
DOI:
10.1016/j.meatsci.2022.108998
PubMed:
36265228

Isolation of secondary metabolites from Syzygium aromaticum (L.) Merr. & L.M.Perry. (cloves), and evaluation of their biological activities.

Kiran Z et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2022.2112956
PubMed:
35997246

Identification and prioritization of promising lead molecules from Syzygium aromaticum against Sortase C from Streptococcus pyogenes: an in silico investigation.

Mangal P et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2022.2086921
PubMed:
35706070

Antibacterial, antioxidant, and cytotoxic activities of Syzygium aromaticum (L.) Merr. & Perry essential oil with identification of its chemical constituents.

Phytochemistry
Al-Zereini WA et al (2022).
Z Naturforsch C J Biosci.
DOI:
10.1515/znc-2022-0056
PubMed:
35599246

Clove Essential Oil (Syzygium aromaticum L. Myrtaceae): Extraction, Chemical Composition, Food Applications, and Essential Bioactivity for Human Health.

Review Phytochemistry
Haro-González JN et al (2021).
Molecules.
DOI:
10.3390/molecules26216387
PubMed:
34770801

Molecular Basis of the Therapeutical Potential of Clove (Syzygium aromaticum L.) and Clues to Its Anti-COVID-19 Utility.

Summary

This article explores the potential of using clove as a therapeutic treatment for COVID-19. Clove has been traditionally used for respiratory ailments and has antiviral, anti-inflammatory, and antithrombotic properties. The authors discuss the scientific literature on the molecular constituents of clove and their effects on COVID-19. Clove may be a promising option for treating COVID-19 patients as a short-term solution while waiting for global immunization.

Review COVID-19
Vicidomini C, Roviello V and Roviello GN (2021).
Molecules.
DOI:
10.3390/molecules26071880
PubMed:
33810416

Syzygium aromaticum L. (Myrtaceae): Traditional Uses, Bioactive Chemical Constituents, Pharmacological and Toxicological Activities.

Review
Batiha GE et al (2020).
Biomolecules.
DOI:
10.3390/biom10020202
PubMed:
32019140