Tanacetum parthenium

Common Names: feverfew

Ethnobotanical Studies

Studies

Influence of Abiotic and Biotic Elicitors on Organogenesis, Biomass Accumulation, and Production of Key Secondary Metabolites in Asteraceae Plants.

Review
Petrova M, Miladinova-Georgieva K and Geneva M (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25084197
PubMed:
38673783

A metabolomics approach reveals metabolic disturbance of human cholangiocarcinoma cells after parthenolide treatment.

He Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118075
PubMed:
38513779

A therapeutic strategy of parthenolide in improving imiquimod-induced psoriasis-like skin inflammation targeting IL-36/NETs through skin transdermal therapeutic system.

DermatologyImmunology
Zhan ZY et al (2024).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2024.111824
PubMed:
38461633

Bioinformatics-Guided Discovery of miRNAs Involved in Apoptosis Modulated by Parthenolide Combined with Vincristine in The NALM6 Cell Line.

Bahmei A et al (2024).
Cell J.
DOI:
10.22074/cellj.2024.2013673.1428
PubMed:
38459731

An Integrative Approach to Selected Species of Tanacetum L. (Asteraceae): Insights into Morphology and Phytochemistry.

Phytochemistry
Giuliani C et al (2024).
Plants (Basel).
DOI:
10.3390/plants13020155
PubMed:
38256709

Regioselective and Stereoselective Synthesis of Parthenolide Analogs by Acyl Nitroso-Ene Reaction and Their Biological Evaluation against Mycobacterium tuberculosis.

Gioia B et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms242417395
PubMed:
38139224

Assessment of the chemical and genetic variability among accessions of Cicerbita alpina (L.) Wallr., an alpine plant with anthelmintic properties.

Martinidou E et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1269613
PubMed:
38078086

Role of parthenolide in paclitaxel-induced oxidative stress injury and impaired reproductive function in rat testicular tissue.

Summary

Parthenolide, a plant extract, can alleviate testicular toxicity caused by paclitaxel, reducing oxidative stress and improving antioxidant levels and gene expression related to reproduction in rats, potentially offering a treatment for PTX-induced testicular damage.

Immunology
Toraman E et al (2023).
Chem Biol Interact.
DOI:
10.1016/j.cbi.2023.110793
PubMed:
37949423

Phenolic Composition and Antioxidant Activity of Tanacetum parthenium Cultivated in Different Regions of Ukraine: Insights into the Flavonoids and Hydroxycinnamic Acids Profile.

ImmunologyPhytochemistry
Hordiei K et al (2023).
Plants (Basel).
DOI:
10.3390/plants12162940
PubMed:
37631152

Parthenolide as a potential analgesic in the treatment of paclitaxel-induced neuropathic pain: the rat modeling.

Summary

Parthenolide, found in Tanacetum parthenium, was tested on rats with neuropathic pain caused by paclitaxel. PTL treatment at 4 mg/kg effectively reduced pain, regulated gene and protein expression, and improved tissue damage.

Pain
Toraman E et al (2023).
Naunyn Schmiedebergs Arch Pharmacol.
DOI:
10.1007/s00210-023-02568-5
PubMed:
37306715

Natural Anticancer Agents: Their Therapeutic Potential, Challenges,s and Promising Outcomes.

Summary

Plant-based drugs show potential for treating various types of cancer, with compounds like curcumin and quercetin having extensive research and promising results. This study reviews several plants and their key compounds with anticancer activity, highlighting potential clinical candidates.

Cancer
Tauro S et al (2023).
Curr Med Chem.
DOI:
10.2174/0929867330666230502113150
PubMed:
37138435

In vitro analysis of green synthesized CuO nanoparticles using Tanacetum parthenium extract for multifunctional applications.

Ranjbar M, Khakdan F and Mukherjee A (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-023-26706-x
PubMed:
37017848

Phytochemical and physiological reactions of feverfew (Tanacetum parthenium (L.) Schultz Bip) to TiO(2) nanoparticles.

Phytochemistry
Shahhoseini R and Daneshvar H (2023).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2022.12.011
PubMed:
36563573

Recent advances on the structural modification of parthenolide and its derivatives as anticancer agents.

Review Cancer
Liu X and Wang X (2022).
Chin J Nat Med.
DOI:
10.1016/S1875-5364(22)60238-3
PubMed:
36427916

Individual lipid transfer proteins from Tanacetum parthenium show different specificity for extracellular accumulation of sesquiterpenes.

Phytochemistry
Kashkooli AB et al (2023).
Plant Mol Biol.
DOI:
10.1007/s11103-022-01316-2
PubMed:
36255594

First Discovery of Cholesterol-Lowering Activity of Parthenolide as NPC1L1 Inhibitor.

Liu W et al (2022).
Molecules.
DOI:
10.3390/molecules27196270
PubMed:
36234807

Sesquiterpene Lactones and Cancer: New Insight into Antitumor and Anti-inflammatory Effects of Parthenolide-Derived Dimethylaminomicheliolide and Micheliolide.

Review ImmunologyPhytochemistry
Dong Y, Qian X and Li J (2022).
Comput Math Methods Med.
DOI:
10.1155/2022/3744837
PubMed:
35898475

Nutraceuticals and migraine: further strategy for the treatment of specific conditions.

Quintana S, Russo M and Torelli P (2022).
Neurol Sci.
DOI:
10.1007/s10072-022-06250-1
PubMed:
35792970

In vitro evaluation of the effects of methanolic plant extracts on the embryonation rate of Ascaridia galli eggs.

Poulopoulou I et al (2022).
Vet Res Commun.
DOI:
10.1007/s11259-022-09958-9
PubMed:
35727416

The effects of several abiotic elicitors on the expression of genes of key enzymes involved in the parthenolide biosynthetic pathway and its content in feverfew plant (Tanacetum parthenium L.).

Genetics
Darbahani M et al (2022).
Nat Prod Res.
DOI:
10.1080/14786419.2022.2055555
PubMed:
35356827

COVID-19: General Strategies for Herbal Therapies.

Summary

Researchers are exploring the potential of natural products to manage the COVID-19 pandemic, resulting in several medicinal plants and compounds being identified for both prevention and treatment. The use of natural products can include mechanisms such as boosting the immune response, blocking virus entry, and inhibiting replication. Examples of effective compounds include aloin, glycyrrhizin, and terpenes. Recognizing these mechanisms can lead to a more systematic approach to finding natural products and medicinal plants for COVID-19.

COVID-19
Soleymani S et al (2022).
J Evid Based Integr Med.
DOI:
10.1177/2515690X211053641
PubMed:
34985368

Repellent activity of Tanacetum parthenium (L.) and Tanacetum vulgare (L.) essential oils against Leptinotarsa decemlineata (Say).

Phytochemistry
Lazarević J et al (2021).
Bull Entomol Res.
DOI:
10.1017/S0007485320000504
PubMed:
32778187

Herbal treatments for migraine: A systematic review of randomised-controlled studies.

Lopresti AL, Smith SJ and Drummond PD (2020).
Phytother Res.
DOI:
10.1002/ptr.6701
PubMed:
32310327

Tanacetum parthenium enhances pentobarbital-induced sleeping behaviors.

Forouzanfar F et al (2020).
Avicenna J Phytomed.
PubMed:
31921609

Feverfew.

Review
(2022).
PubMed:
30000921

Parthenium dermatitis.

Review Dermatology
Sharma VK and Sethuraman G (2007).
Dermatitis.
PubMed:
18021597