The Zhuidu Formula (ZDF) contains triptolide, cinobufagin, and paclitaxel, derived from natural sources. Studies have shown that these compounds have anti-tumor properties by affecting DNA synthesis, promoting tumor cell death, and disrupting tubulin balance. However, their role in inhibiting triple-negative breast cancer (TNBC) metastasis remains unclear. Understanding this mechanism could lead to new treatments for TNBC.