Terminalia chebula

Common Names: myrobalan

Ethnobotanical Studies

Studies

Modeling and Optimization of Ellagic Acid from Chebulae Fructus Using Response Surface Methodology Coupled with Artificial Neural Network.

Wu J et al (2024).
Molecules.
DOI:
10.3390/molecules29163953
PubMed:
39203031

Studies on In Vitro Antimicrobial, Anticancer, and Anti-oxidative Inflammatory Response of Methanolic Tuber Extracts Derived From Terminalia chebula.

Summary

Study investigated antibacterial, antifungal, & anticancer effects of methanolic tuber extracts. Extracts showed cytotoxic effects on oral cancer cells, antioxidant & anti-inflammatory activities, and significant antibacterial effects. Potential therapeutic & commercial value, more research needed on active components and mechanisms.

AntimicrobialCancerImmunology
Suresh Kumar D et al (2024).
Cureus.
DOI:
10.7759/cureus.63930
PubMed:
39109124

A Novel Gum Paint Formulation Derived From Licorice and Triphala: Characteristics and Clinical Significance for Improved Oral Health.

Kannan N et al (2024).
Cureus.
DOI:
10.7759/cureus.63940
PubMed:
39105027

Natural product-based treatment potential for type 2 diabetes mellitus and cardiovascular disease.

Summary

Researchers investigated the link between type 2 diabetes and cardiovascular disease, finding common risk factors and proposing natural supplement treatment. This could be a promising preventive and therapeutic option for both diseases.

CardiologyDiabetes
Shrivastav D et al (2024).
World J Diabetes.
DOI:
10.4239/wjd.v15.i7.1603
PubMed:
39099809

Screening and characterization of cosmetic efficacy components of Terminalia chebula based on biological activity-guided methodology.

Liang CC, Zhang FQ and Chen J (2024).
Biomed Chromatogr.
DOI:
10.1002/bmc.5974
PubMed:
39090681

Isolation of a novel quercetin derivative from Terminalia chebula and RT-PCR-assisted probing to investigate its DNA repair in hepatoma cells.

Genetics
Soumya K et al (2024).
Res Pharm Sci.
DOI:
10.4103/RPS.RPS_56_23
PubMed:
39035817

[Terminalia chebula water extract reduces joint inflammation by regulating cellular immunity in spleen cells of collagen-induced arthritis (CIA) rats through up-regulation of PD-1/PD-L1].

ArthritisImmunology
Wu Q et al (2024).
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi.
PubMed:
38952088

Inhibition of SARS-CoV-2-Induced NLRP3 Inflammasome-Mediated Lung Cell Inflammation by Triphala-Loaded Nanoparticle Targeting Spike Glycoprotein S1.

Summary

Nanoparticles loaded with Triphala (nanotriphala) show promise as a anti-inflammatory therapy for COVID-19. Chebulagic acid and chebulinic acid are the active compounds reducing cytokine release and inflammation.

COVID-19Immunology
Chittasupho C et al (2024).
Pharmaceutics.
DOI:
10.3390/pharmaceutics16060751
PubMed:
38931873

Revealing microbial diversity in buffalo milk with high somatic cell counts: implications for mastitis diagnosis and treatment.

Jiang H et al (2024).
Vet Res Commun.
DOI:
10.1007/s11259-024-10438-5
PubMed:
38874832

A standardized combination of Terminalia chebula and Withania somnifera extracts enhances immune function in adults: a pilot randomized, double-blind, placebo-controlled clinical study.

Sadhupati DP et al (2024).
Food Nutr Res.
DOI:
10.29219/fnr.v68.10297
PubMed:
38863743

Terminalia chebula attenuates restraint stress-induced memory impairment and synaptic loss in the dentate gyrus of the hippocampus and the basolateral and central nuclei of the amygdala by inhibiting oxidative damage.

Summary

Terminalia chebula reduces cognitive abnormalities from chronic stress by improving memory, synaptic density, and antioxidant levels in the brain. This suggests potential neuroprotective effects of Terminalia chebula in stress-induced conditions.

Neuroscience
Khazani H et al (2024).
Brain Res Bull.
DOI:
10.1016/j.brainresbull.2024.110975
PubMed:
38734185

Sustainable synthesis of spongy-like porous carbon for supercapacitive energy storage systems towards pollution control.

Kishore SC et al (2024).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-024-33437-0
PubMed:
38684614

Exploring Anticancer Properties of Medicinal Plants against Breast Cancer by Downregulating Human Epidermal Growth Factor Receptor 2.

Summary

Various medicinal plants show promising anticancer activity against HER2-positive breast cancer cells by reducing HER2 expression, altering proteome profile, and containing multiple anticancer compounds. Potential innovative therapies for HER2-positive breast cancer.

Cancer
Gupta S et al (2024).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.3c07565
PubMed:
38624258

Development of a virus-based affinity ultrafiltration method for screening virus-surface-protein-targeted compounds from complex matrixes: Herbal medicines as a case study.

Li Z et al (2024).
J Med Virol.
DOI:
10.1002/jmv.29517
PubMed:
38476091

1,3,6-Trigalloylglucose: A Novel Potent Anti-Helicobacter pylori Adhesion Agent Derived from Aqueous Extracts of Terminalia chebula Retz.

Ou L et al (2024).
Molecules.
DOI:
10.3390/molecules29051161
PubMed:
38474673

Evaluation and comparison of antibacterial efficacy of different concentrations of Chhattisgarh herbal product-Terminalia chebula fruit extract in opposition to Enterococcus faecalis: An in vitro study.

Doye SD et al (2023).
Food Sci Nutr.
DOI:
10.1002/fsn3.3814
PubMed:
38370068

Evaluation of the biological efficiency of Terminalia chebula fruit extract against neurochemical changes induced in brain of diabetic rats: an epigenetic study.

Summary

The study found that the ethanolic Terminalia chebula extract reduced oxidative stress, improved brain integrity, and decreased abnormal changes in the brains of diabetic rats. This suggests that T. chebula extract could potentially be beneficial for the treatment of diabetes-related neuroinflammation.

DiabetesNeuroscience
El-Shamarka MEA et al (2024).
Inflammopharmacology.
DOI:
10.1007/s10787-024-01428-9
PubMed:
38329710

Green Synthesis of Copper Oxide Nanoparticles Synthesized by Terminalia chebula Dried Fruit Extract: Characterization and Antibacterial Action.

Munusamy T and Shanmugam R (2023).
Cureus.
DOI:
10.7759/cureus.50142
PubMed:
38186403

Global Profiling of the Antioxidant Constituents in Chebulae Fructus Based on an Integrative Strategy of UHPLC/IM-QTOF-MS, MS/MS Molecular Networking, and Spectrum-Effect Correlation.

Immunology
Wang X et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12122093
PubMed:
38136213

Baiheqingjin formula reduces inflammation in mice with asthma by inhibiting the PI3K/AKT/NF-κb signaling pathway.

Summary

BHQJ is a traditional Chinese herbal remedy made from 7 plants. It effectively treats cough asthma and reduces airway inflammation.

AsthmaImmunology
Yan X et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117565
PubMed:
38081397

Preliminary data on cytotoxicity and functional group assessment of a herb-mineral combination against colorectal carcinoma cell line.

Gastroenterology
Jayakumar R et al (2023).
J Complement Integr Med.
DOI:
10.1515/jcim-2023-0221
PubMed:
38016708

Preventive mechanisms of Chinese Tibetan medicine Triphala against nonalcoholic fatty liver disease.

Jiang Y et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155229
PubMed:
38006804

Terminalia chebula Retz. aqueous extract inhibits the Helicobacter pylori-induced inflammatory response by regulating the inflammasome signaling and ER-stress pathway.

Immunology
Ou L et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117428
PubMed:
37981121

Efficacy of a herbal mouthwash for management of periodontitis and radiation-induced mucositis - A consolidated report of two randomized controlled clinical trials.

Ambili R et al (2023).
J Ayurveda Integr Med.
DOI:
10.1016/j.jaim.2023.100791
PubMed:
37897968

The Importance of Visceral Hypersensitivity in Irritable Bowel Syndrome-Plant Metabolites in IBS Treatment.

Review
Dudzińska E et al (2023).
Pharmaceuticals (Basel).
DOI:
10.3390/ph16101405
PubMed:
37895876

Metabolomics and molecular networking approach for exploring the anti-diabetic activity of medicinal plants.

Summary

Researchers analyzed four medicinal plants and found that Plant A's methanol extract was most effective against α-amylase, while Plant B's water fraction showed strong α-glucosidase inhibition. Metabolic profiling revealed 32 secondary metabolites, with 22 tentatively identified.

Diabetes
Timilsina AP et al (2023).
RSC Adv.
DOI:
10.1039/d3ra04037b
PubMed:
37869390

Structural insights into modeling of hepatitis B virus reverse transcriptase and identification of its inhibitors from potential medicinal plants of Western Ghats: an in silico and in vitro study.

Genetics
Patil VS et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2264400
PubMed:
37811543

Cell cycle arrest and apoptotic studies of Terminalia chebula against MCF-7 breast cancer cell line: an in vitro and in silico approach.

Summary

Terminalia chebula fruit extract (TCF) shows potential as a targeted therapy for breast cancer, with antiproliferative effects and induction of apoptosis. Saccharopine, a phytochemical in TCF, has a higher binding affinity with EGFR. Promising for developing novel anticancer agents from plants.

Cancer
Reddy P et al (2023).
Front Oncol.
DOI:
10.3389/fonc.2023.1221275
PubMed:
37706181

Chebulinic Acid: An Incipient Anticancer Agent.

Summary

T. chebula and chebulinic acid have multiple medicinal properties, including antimicrobial, antioxidant, anti-inflammatory, and hepatoprotective effects. They have potential use in treating various diseases and may be beneficial for general health and disease prevention.

Cancer
Aashima et al (2023).
Recent Pat Anticancer Drug Discov.
DOI:
10.2174/1574892819666230821110429
PubMed:
37605424

Preclinical Pharmacokinetics and CYP Modulation Activity of Chebulinic Acid: A Potent Molecule Against Metabolic Disease.

Biswas A et al (2023).
Curr Drug Metab.
DOI:
10.2174/1389200224666230817101950
PubMed:
37592800

Comparative evaluation of the potential anti-spasmodic activity of Piper longum, Piper nigrum, Terminalia bellerica, Terminalia chebula, and Zingiber officinale in experimental animals.

Tiwari BR et al (2023).
Saudi Pharm J.
DOI:
10.1016/j.jsps.2023.101705
PubMed:
37576742

Phenytoin's Pharmacological Interactions with Medicinal Herbs: A Review.

Review
Taleb MH et al (2023).
Pharmazie.
DOI:
10.1691/ph.2023.3546
PubMed:
37537774

Inhibition mechanisms of four ellagitannins from terminalia chebula fruits on acetylcholinesterase by inhibition kinetics, spectroscopy and molecular docking analyses.

Summary

Four ellagitannins from Terminalia chebula fruits inhibit acetylcholinesterase (AChE), a target for Alzheimer's treatment. They cause structural changes in AChE, making them potential natural inhibitors for Alzheimer's.

Neuroscience
Li YJ et al (2023).
Spectrochim Acta A Mol Biomol Spectrosc.
DOI:
10.1016/j.saa.2023.123115
PubMed:
37453379

Optimization of extraction and dyeing conditions of the Parkia roxburghii pod's peel as a natural substantive silk dye.

Shantibala T, Talha Ansari M and Tatan T (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2023.2225124
PubMed:
37322872

Commiphora mukul (Hook. ex Stocks) Engl.: Historical records, application rules, phytochemistry, pharmacology, clinical research, and adverse reaction.

Summary

The herb Commiphora mukul has been used for centuries to treat various health conditions. It has potential medicinal and commercial value and should be studied more.

Review Phytochemistry
Garang Z et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116717
PubMed:
37301302

Validation and standardization of Gallic acid and Ellagic acid in Quercus infectoria, Terminalia chebula and Pistacia integerrima.

Saini AK et al (2023).
J AOAC Int.
DOI:
10.1093/jaoacint/qsad070
PubMed:
37294736

The therapeutic mechanism of Chebulae Fructus in the treatment of immunosuppression in Chinese yellow quail on the basis of network pharmacology.

Wu Q et al (2023).
Front Vet Sci.
DOI:
10.3389/fvets.2023.1123449
PubMed:
37275616

Treatment with Terminalia chebula Extract Reduces Insulin Resistance, Hyperglycemia and Improves SIRT1 Expression in Type 2 Diabetic Rats.

Diabetes
Agrawal OD and Kulkarni YA (2023).
Life (Basel).
DOI:
10.3390/life13051168
PubMed:
37240813

Terminalia chebula-Assisted Silver Nanoparticles: Biological Potential, Synthesis, Characterization, and Ecotoxicity.

Tharani M et al (2023).
Biomedicines.
DOI:
10.3390/biomedicines11051472
PubMed:
37239143

Evaluation of the efficacy of topical Terminalia chebula Retz. with vinegar in the treatment of tinea corporis: a non-inferiority randomized controlled trial.

Tasneem Parapur S et al (2023).
Drug Metab Pers Ther.
DOI:
10.1515/dmpt-2022-0188
PubMed:
37012894

The Chronic and Acute Toxicity of Traditional Medicines Containing Terminalia chebula.

Arongqiqige et al (2023).
J Pharmacopuncture.
DOI:
10.3831/KPI.2023.26.1.18
PubMed:
37007288

Effectiveness of final cavity disinfectant terminalia chebula, malachite, and indocyanine green, against E. Faecalis and on the bond interface of fiber post to radicular dentin.

Antimicrobial
Maawadh AM et al (2023).
Photodiagnosis Photodyn Ther.
DOI:
10.1016/j.pdpdt.2023.103538
PubMed:
37001714

Reduction of senescence-associated secretory phenotype and exosome-shuttled miRNAs by Haritaki fruit extract in senescent dermal fibroblasts.

Bogdanowicz P et al (2023).
Int J Cosmet Sci.
DOI:
10.1111/ics.12858
PubMed:
36940283

Effects of the Ethanol and Ethyl Acetate Extracts of Terminalia chebula Retz. on Proliferation, Migration, and HIF-1α and CXCR-4 Expression in MCF-7 Cells: an In Vitro Study.

Mehrabani M et al (2023).
Appl Biochem Biotechnol.
DOI:
10.1007/s12010-022-04301-z
PubMed:
36585552

Molecular insights into the in silico discovery of corilagin from Terminalia chebula as a potential dual inhibitor of SARS-CoV-2 structural proteins.

COVID-19
Pradeep S et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2022.2158943
PubMed:
36576118

Development and Validation of a Green Stability-Indicating HPTLC Method for Estimation of Curcumin, Gallic Acid, and Ursolic Acid From Polyherbal Formulation Jatyadi Taila.

Patel MN et al (2023).
J AOAC Int.
DOI:
10.1093/jaoacint/qsac147
PubMed:
36440895

A comprehensive review on the diverse pharmacological perspectives of Terminalia chebula Retz.

Review
Hassan Bulbul MR et al (2022).
Heliyon.
DOI:
10.1016/j.heliyon.2022.e10220
PubMed:
36051270

Terminalia chebula Retz. extract ameliorates the symptoms of atopic dermatitis by regulating anti-inflammatory factors in vivo and suppressing STAT1/3 and NF-ĸB signaling in vitro.

DermatologyImmunology
Kim HJ et al (2022).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154318
PubMed:
35830757

Facial Aging Improvement Case Study Using a Novel Combination of Retinol, Niacinamide, and Terminalia Chebula.

Handler M et al (2022).
J Drugs Dermatol.
DOI:
10.36849/JDD.6621
PubMed:
35816074

Fruits of Terminalia chebula Retz.: A review on traditional uses, bioactive chemical constituents and pharmacological activities.

Review
Nigam M et al (2020).
Phytother Res.
DOI:
10.1002/ptr.6702
PubMed:
32307775

[Pharmacological activity of Terminalia chebula].

Review
Zhang XJ et al (2016).
Zhongguo Zhong Yao Za Zhi.
DOI:
10.4268/cjcmm20160412
PubMed:
28871682

Therapeutic Uses of Triphala in Ayurvedic Medicine.

Review
Peterson CT, Denniston K and Chopra D (2017).
J Altern Complement Med.
DOI:
10.1089/acm.2017.0083
PubMed:
28696777

Potential therapeutic applications for Terminalia chebula in Iranian traditional medicine.

Review
Jokar A et al (2016).
J Tradit Chin Med.
PubMed:
27400482

A Review on Potential Mechanisms of Terminalia chebula in Alzheimer's Disease.

Summary

Alzheimer's disease is currently treated with acetylcholinesterase inhibitors (AChEIs) and NMDA receptor antagonists, which have drawbacks. A medicinal plant called Terminalia chebula has been studied for its potential as a therapeutic alternative due to its biochemicals, including hydrolysable tannins, phenolic compounds, and flavonoids. The use of this plant was reviewed in various databases, and it was found that T. chebula extracts and its constituents have AChEI and antioxidant and anti-inflammatory effects, all of which are relevant to the treatment of Alzheimer's disease.

Review Neuroscience
Afshari AR, Sadeghnia HR and Mollazadeh H (2016).
Adv Pharmacol Sci.
DOI:
10.1155/2016/8964849
PubMed:
26941792

Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity.

Review
Jadoon S et al (2015).
Oxid Med Cell Longev.
DOI:
10.1155/2015/709628
PubMed:
26448818

The development of Terminalia chebula Retz. (Combretaceae) in clinical research.

Review
Bag A, Bhattacharyya SK and Chattopadhyay RR (2013).
Asian Pac J Trop Biomed.
DOI:
10.1016/S2221-1691(13)60059-3
PubMed:
23620847