Tetradium ruticarpum

Ethnobotanical Studies

Studies

Dehydroevodiamine targeting IKKβ to alleviate acute gastric injury via inhibiting the p65/NLRP3 axis.

Summary

DHE from Tetradium ruticarpum may help treat acute gastric injury by studying its mechanisms. This could improve patient quality of life and overall health.

Gastroenterology
Hu Q et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155963
PubMed:
39241388

The anti-cholestatic effects of Coptis chinensis Franch. alone and combined with Tetradium ruticarpum (A. Jussieu) T. G. Hartley: dual effects on fecal metabolism and microbial diversity.

Han J et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1372527
PubMed:
38523644

Limonin inhibits the stemness of cancer stem-like cells derived from colorectal carcinoma cells potentially via blocking STAT3 signaling.

Summary

Limonin, a common ingredient in citrus fruits, shows potential for antitumor effects on colorectal cancer cells and cancer stem-like cells, which could improve outcomes for patients with CRC.

CancerGastroenterologyImmunology
Zhang WF et al (2024).
World J Clin Oncol.
DOI:
10.5306/wjco.v15.i2.317
PubMed:
38455137

The zhuyu pill relieves rat cholestasis by regulating the mRNA expression of lipid and bile metabolism associated genes.

Summary

The Zhuyu pill (ZYP), a traditional Chinese medicine, was tested on cholestasis rat models. ZYP improved abnormal biochemical and histopathology changes in the liver, regulating pathways related to bile and lipid metabolism. ZYP has potential as a treatment for cholestasis.

Genetics
Han J et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1280864
PubMed:
37881184

Integrated network pharmacology and metabolomics to investigate the effects and possible mechanisms of Dehydroevodiamine against ethanol-induced gastric ulcers.

Summary

Researchers investigated the effect of dehydroevodiamine (DHE), a compound found in traditional Chinese medicine Tetradium ruticarpum, on ethanol-induced gastric ulcers. DHE has previously shown anti-inflammatory, analgesic, and antioxidant effects. Understanding its impact on gastric ulcers may have implications for treating such conditions.

Gastroenterology
Wang X et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117340
PubMed:
37879508

The inhibitory effect of licorice on the hepatotoxicity induced by the metabolic activation of Euodiae Fructus.

Ren K et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117233
PubMed:
37793580

Combining transcriptomics and network pharmacology to reveal the mechanism of Zuojin capsule improving spasmolytic polypeptide-expressing metaplasia.

Genetics
Xiong M et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117075
PubMed:
37625606

Chromatographic and mass spectrometric technologies for chemical analysis of Euodiae fructus: A review.

Review
Xia H et al (2023).
Phytochem Anal.
DOI:
10.1002/pca.3187
PubMed:
36442477

Mechanisms of pancreatic tumor suppression mediated by Xiang-lian pill: An integrated in silico exploration and experimental validation.

Cancer
Jiao J et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115586
PubMed:
35931303

Untargeted LC-MS/MS-Based Multi-Informative Molecular Networking for Targeting the Antiproliferative Ingredients in Tetradium ruticarpum Fruit.

Cancer
Su CH et al (2022).
Molecules.
DOI:
10.3390/molecules27144462
PubMed:
35889335

Chemical Investigation of Tetradium ruticarpum Fruits and Their Antibacterial Activity against Helicobacter pylori.

Na MW et al (2022).
ACS Omega.
DOI:
10.1021/acsomega.2c02380
PubMed:
35847243

Uncovering the mechanism of Huanglian-Wuzhuyu herb pair in treating nonalcoholic steatohepatitis based on network pharmacology and experimental validation.

Zhang X et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115405
PubMed:
35644437

Rutaecarpine ameliorates lipopolysaccharide-induced BEAS-2B cell injury through inhibition of endoplasmic reticulum stress via activation of the AMPK/SIRT1 signaling pathway.

Zhang H et al (2022).
Exp Ther Med.
DOI:
10.3892/etm.2022.11300
PubMed:
35495603

Toxicity of Tetradium ruticarpum: Subacute Toxicity Assessment and Metabolomic Identification of Relevant Biomarkers.

Shan Q et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.803855
PubMed:
35295336

Zuojin Pill ameliorates chronic atrophic gastritis induced by MNNG through TGF-β1/PI3K/Akt axis.

Tong Y et al (2021).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2021.113893
PubMed:
33524511

Traditional uses, phytochemistry, pharmacology, pharmacokinetics and toxicology of the fruit of Tetradium ruticarpum: A review.

Review Phytochemistry
Li M and Wang C (2020).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2020.113231
PubMed:
32758577

Processing and Polyherbal Formulation of Tetradium ruticarpum (A. Juss.) Hartley: Phytochemistry, Pharmacokinetics, and Toxicity.

Review Phytochemistry
Shan QY et al (2020).
Front Pharmacol.
DOI:
10.3389/fphar.2020.00133
PubMed:
32210796

Evodiamine and rutaecarpine from Tetradium ruticarpum in the treatment of liver diseases.

Review
Li X et al (2020).
Phytomedicine.
DOI:
10.1016/j.phymed.2020.153180
PubMed:
32092638