Tetrastigma hemsleyanum

Ethnobotanical Studies

Studies

Evaluation of reference genes and expression patterns of CONSTANS-LIKE genes in Tetrastigma hemsleyanum under different photoperiods.

Genetics
Zhao G et al (2024).
Funct Plant Biol.
DOI:
10.1071/FP23218
PubMed:
39038159

Tetrastigma hemsleyanum polysaccharide combined with doxorubicin promote ferroptosis and immune function in triple-negative breast cancer.

Summary

THP from Tetrastigma hemsleyanum induces ferroptosis in TNBC cells, enhancing sensitivity to DOX. It improves tumor microenvironment, immune function, and organ toxicity caused by DOX, presenting a potential treatment strategy for TNBC.

Cancer
Shang Y et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.133424
PubMed:
38945330

Tetrastigma hemsleyanum polysaccharide ameliorates cytokine storm syndrome via the IFN-γ-JAK2/STAT pathway.

Summary

Researchers found that Tetrastigma hemsleyanum polysaccharide (THP) reduced lung injury and inflammation in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) by targeting the IFN-γ-JAK2/STAT signaling pathway, showing therapeutic potential.

Immunology
Fu S et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.133427
PubMed:
38936586

The influence of prolonged but low intensity blue light on the physiological properties of root tubers and the accumulation of flavonoids in Tetrastigma hemsleyanum Diels et Gilg.

Summary

Researchers found that supplementing Tetrastigma hemsleyanum with low-density blue light increased root tuber yield and flavonoid content, improving antioxidant properties. Understanding this can lead to better cultivation practices and potential medicinal applications.

Phytochemistry
Zhao G et al (2024).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2024.108824
PubMed:
38936072

Molecular mechanisms of Tetrastigma hemsleyanum Diels&Gilg against lung squamous cell carcinoma: From computational biology and experimental validation.

Li P et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118326
PubMed:
38750988

Kaempferol 3-O-Rutinoside, a Flavone Derived from Tetrastigma hemsleyanum Diels et Gilg, Reduces Body Temperature through Accelerating the Elimination of IL-6 and TNF-α in a Mouse Fever Model.

Immunology
Zheng W et al (2024).
Molecules.
DOI:
10.3390/molecules29071641
PubMed:
38611918

Revealing quality chemicals of Tetrastigma hemsleyanum roots in different geographical origins using untargeted metabolomics and random-forest based spectrum-effect analysis.

Chu C et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.139207
PubMed:
38579655

Tetrastigma hemsleyanum (Sanyeqing) root extracts evoke S phase arrest while inhibiting the migration and invasion of human pancreatic cancer PANC-1 cells.

Summary

EFT extracts from Tetrastigma hemsleyanum show promise in fighting cancer. Study explores how they work against pancreatic cancer cells. Important for potential cancer therapies.

Cancer
Sun Y et al (2024).
BMC Complement Med Ther.
DOI:
10.1186/s12906-024-04425-1
PubMed:
38539165

A glucuronogalactomannan isolated from Tetrastigma hemsleyanum Diels et Gilg: Structure and immunomodulatory activity.

Summary

TL;DR: STHP-5, a polysaccharide from Tetrastigma hemsleyanum, stimulates macrophages and activates TLR4, potentially serving as a novel immunomodulator.

Immunology
Mao Z et al (2024).
Carbohydr Polym.
DOI:
10.1016/j.carbpol.2024.121922
PubMed:
38494202

Differential effects of winter cold stress on soil bacterial communities, metabolites, and physicochemical properties in two varieties of Tetrastigma hemsleyanum Diels & Gilg in reclaimed land.

Phytochemistry
Li X et al (2024).
Microbiol Spectr.
DOI:
10.1128/spectrum.02425-23
PubMed:
38470484

Exogenous titanium dioxide nanoparticles alleviate cadmium toxicity by enhancing the antioxidative capacity of Tetrastigma hemsleyanum.

Huang Y et al (2024).
Ecotoxicol Environ Saf.
DOI:
10.1016/j.ecoenv.2024.116166
PubMed:
38430577

Full-length transcriptome reveals the pivotal role of ABA and ethylene in the cold stress response of Tetrastigma hemsleyanum.

Summary

This study analyzed the response of plants to cold stress. They found that genes related to plant hormone signaling pathways and ABA and ethylene played a vital role in cold tolerance. The findings provide insights for improving cold tolerance in plants.

Genetics
Qian L et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2024.1285879
PubMed:
38357266

Multi-omics combined with MALDI mass spectroscopy imaging reveals the mechanisms of biosynthesis of characteristic compounds in Tetrastigma hemsleyanum Diels et Gilg.

Lin Y et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1294804
PubMed:
38264025

Antipyretic effect of inhaled Tetrastigma hemsleyanum polysaccharide on substance and energy metabolism in yeast-induced pyrexia mice via TLR4/NF-κb signaling pathway.

Summary

Tetrastigma hemsleyanum is a useful plant for treating severe infectious diseases, but we don't know how it works. Understanding its mechanism could lead to better treatments.

Immunology
Fu S et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117732
PubMed:
38218501

Role of plant metabolites in the formation of bacterial communities in the rhizosphere of Tetrastigma hemsleyanum.

Huang Y et al (2023).
Front Microbiol.
DOI:
10.3389/fmicb.2023.1292896
PubMed:
38163074

Bioactives and metabolites of Tetrastigma hemsleyanum root extract alleviate DSS-induced ulcerative colitis by targeting the SYK protein in the B cell receptor signaling pathway.

Gastroenterology
Feng Z, Ye W and Feng L (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117563
PubMed:
38104876

Insights into Metabolic Engineering of Bioactive Molecules in Tetrastigma hemsleyanum Diels & Gilg: A Traditional Medicinal Herb.

Review
Krishna TPA et al (2023).
Curr Genomics.
DOI:
10.2174/0113892029251472230921053135
PubMed:
37994327

Functional characterization of a cold related flavanone 3-hydroxylase from Tetrastigma hemsleyanum: an in vitro, in silico and in vivo study.

Wu L et al (2023).
Biotechnol Lett.
DOI:
10.1007/s10529-023-03440-5
PubMed:
37910279

Fermentation-mediated variations in structure and biological activity of polysaccharides from Tetrastigma hemsleyanum Diels et Gilg.

Cheng J et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.127463
PubMed:
37852397

Polysaccharides from Tetrastigma Hemsleyanum Diels et Gilg ameliorated inflammatory bowel disease by rebuilding the intestinal mucosal barrier and inhibiting inflammation through the SCFA-GPR41/43 signaling pathway.

Summary

Tetrastigma hemsleyanum polysaccharide (THP) reduces inflammation, promotes intestinal barrier integrity, regulates gut microbiota, and activates SCFAs-GPR41/43 signaling pathway in inflammatory bowel disease.

GastroenterologyImmunology
Lin Y et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.126167
PubMed:
37558022

Tetrastigma hemsleyanum suppresses neuroinflammation in febrile seizures rats via regulating PKC-δ/caspase-1 signaling pathway.

Summary

T. hemsleyanum has a long history in China for preventing and treating FS. Understanding its mechanisms can provide insights for potential therapeutic approaches.

Neuroscience
Ji W et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116912
PubMed:
37451489

Tetrastigma polysaccharide reprogramming of tumor-associated macrophages via PPARγ signaling pathway to play antitumor activity in breast cancer.

Summary

Tetrastigma Hemsleyanum Diels et Gilg (SYQ) is a traditional Chinese medicine used for anti-tumor treatment. Researchers have found that the polysaccharide component of SYQ has antioxidant and anti-inflammatory properties. However, its impact on antitumor activity and the underlying mechanism are not yet well understood. This research aims to uncover the potential benefits of SYQ-PA in fighting tumors, shedding light on its significance for future cancer treatments.

CancerImmunology
Liu X et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116645
PubMed:
37196813

Using landscape genomics to assess local adaptation and genomic vulnerability of a perennial herb Tetrastigma hemsleyanum (Vitaceae) in subtropical China.

Wang Y et al (2023).
Front Genet.
DOI:
10.3389/fgene.2023.1150704
PubMed:
37144128

Screening out Biomarkers of Tetrastigma hemsleyanum for Anti-Cancer and Anti-Inflammatory Based on Spectrum-Effect Relationship Coupled with UPLC-Q-TOF-MS.

CancerImmunology
Xia J et al (2023).
Molecules.
DOI:
10.3390/molecules28073021
PubMed:
37049789

Components research on Tetrastigma hemsleyanum Diels et Gilg: Identification and effect of drying methods on the content of ten main constituents by targeting metabolomics method.

Guo Z, Chen L and Liang X (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115375
PubMed:
37030030

Integrative Analysis of the Transcriptome and Metabolome Reveals the Developmental Mechanisms and Metabolite Biosynthesis of the Tuberous Roots of Tetrastigma hemsleyanum.

Genetics
Hang S et al (2023).
Molecules.
DOI:
10.3390/molecules28062603
PubMed:
36985574

Immunoregulatory effects of Tetrastigma hemsleyanum polysaccharide via TLR4-mediated NF-κB and MAPK signaling pathways in Raw264.7 macrophages.

Immunology
Wu J et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.114471
PubMed:
36889110

Chromosome-level reference genome of Tetrastigma hemsleyanum (Vitaceae) provides insights into genomic evolution and the biosynthesis of phenylpropanoids and flavonoids.

GeneticsPhytochemistry
Zhu S et al (2023).
Plant J.
DOI:
10.1111/tpj.16169
PubMed:
36864731

Flavonoid Metabolism in Tetrastigma hemsleyanum Diels et Gilg Based on Metabolome Analysis and Transcriptome Sequencing.

Genetics
Bai Y et al (2022).
Molecules.
DOI:
10.3390/molecules28010083
PubMed:
36615276

Antitumor effects of polysaccharides from Tetrastigma hemsleyanum Diels et Gilg via regulation of intestinal flora and enhancing immunomodulatory effects in vivo.

CancerImmunology
Zhou F et al (2022).
Front Immunol.
DOI:
10.3389/fimmu.2022.1009530
PubMed:
36389762

Polysaccharides from Tetrastigma Hemsleyanum Diels et Gilg attenuate LPS-induced acute lung injury by modulating TLR4/COX-2/NF-κB signaling pathway.

Immunology
Wang B et al (2022).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2022.113755
PubMed:
36182735

The complete chloroplast genomes of Tetrastigma hemsleyanum (Vitaceae) from different regions of China: molecular structure, comparative analysis and development of DNA barcodes for its geographical origin discrimination.

Genetics
Dong S et al (2022).
BMC Genomics.
DOI:
10.1186/s12864-022-08755-7
PubMed:
36028808

Total flavonoids from the dried root of Tetrastigma hemsleyanum Diels et Gilg inhibit colorectal cancer growth through PI3K/AKT/mTOR signaling pathway.

CancerPhytochemistry
Zhai Y et al (2022).
Phytother Res.
DOI:
10.1002/ptr.7561
PubMed:
35831026

Cyclin-Dependent Kinase 6 Identified as the Target Protein in the Antitumor Activity of Tetrastigma hemsleyanum.

Cancer
Wei C et al (2022).
Front Oncol.
DOI:
10.3389/fonc.2022.865409
PubMed:
35480115

Molecular cloning and structural analysis of key enzymes in Tetrastigma hemsleyanum for resveratrol biosynthesis.

Hu W, Xia P and Liang Z (2021).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2021.08.178
PubMed:
34478792

The research progresses and future prospects of Tetrastigma hemsleyanum Diels et Gilg: A valuable Chinese herbal medicine.

Review
Hu W et al (2021).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2021.113836
PubMed:
33465440

Tetrastigma hemsleyanum leaves extract against acrylamide-induced toxicity in HepG2 cells and Caenorhabditis elegans.

Chu Q et al (2020).
J Hazard Mater.
DOI:
10.1016/j.jhazmat.2020.122364
PubMed:
32114136

Molecular authentication of Tetrastigma hemsleyanum from its adulterant species using ISSR, CAPS, and ITS2 barcode.

Peng X et al (2016).
Mol Biol Rep.
DOI:
10.1007/s11033-016-4023-x
PubMed:
27245064