Thapsia garganica

Ethnobotanical Studies

Studies

Chemical Composition and Insecticidal Activity against Tribolium Castaneum of Thapsia garganica L. Seed Essential Oil.

Phytochemistry
Khemis E et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202200646
PubMed:
36649489

From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development.

Summary

Thapsigargin is a compound found in a plant that inhibits a calcium pump known as SERCA. It has been used as a tool for studying intracellular calcium regulation, protein unfolding, and cell death. Thapsigargin has also been chemically transformed into a prodrug for cancer treatment. However, the drug failed clinical trials, but the chemical synthesis of thapsigargin led to important scientific discoveries. This finding includes new understandings of sesquiterpene lactones, ATPase mechanisms, prodrug development, and plant taxonomy.

Neuroscience
Christensen SB et al (2021).
Prog Chem Org Nat Prod.
DOI:
10.1007/978-3-030-64853-4_2
PubMed:
33797641

Exploring evolutionary theories of plant defence investment using field populations of the deadly carrot.

Review
Martinez-Swatson K et al (2020).
Ann Bot.
DOI:
10.1093/aob/mcz151
PubMed:
31563960

Thapsigargin induces apoptosis in adrenocortical carcinoma by activating endoplasmic reticulum stress and the JNK signaling pathway: an in vitro and in vivo study.

Wu L et al (2019).
Drug Des Devel Ther.
DOI:
10.2147/DDDT.S209947
PubMed:
31496655

Seeds, Leaves and Roots of Thapsia garganica as a Source of New Potent Lipases Inhibitors: In vitro and In silico Studies.

Nebeg H et al (2019).
Endocr Metab Immune Disord Drug Targets.
DOI:
10.2174/1871530319666190128122211
PubMed:
30706829

Use of a temporary immersion bioreactor system for the sustainable production of thapsigargin in shoot cultures of Thapsia garganica.

López CQ et al (2018).
Plant Methods.
DOI:
10.1186/s13007-018-0346-z
PubMed:
30202426

Anti-scorpion venom activity of Thapsia garganica methanolic extract: Histopathological and biochemical evidences.

Bouimeja B et al (2018).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2017.10.003
PubMed:
28993279

Chemodiversity of volatile oils in Thapsia garganica L. (Apiaceae).

Hassen I et al (2015).
Chem Biodivers.
DOI:
10.1002/cbdv.201400218
PubMed:
25879507

Tethered lipids from Thapsia garganica.

Liu H, Olsen CE and Christensen SB (2004).
J Nat Prod.
PubMed:
15387637

Micropropagation of Thapsia garganica--a medicinal plant.

Makunga NP, Jäger AK and Van Staden J (2003).
Plant Cell Rep.
PubMed:
12835906

Thapsia garganica L: a poisonous plant of North Africa.

El Bahri L and Makhlouf M (2001).
Vet Hum Toxicol.
PubMed:
11474736