Tilia americana

Common Names: American basswood

Ethnobotanical Studies

Studies

Systematic review on the anxiolytic and hypnotic effects of flower extracts in in vivo pre-clinical studies published from 2010 to 2020.

Summary

Researchers conducted a systematic review of scientific articles published between 2010 and 2020 that evaluated the anxiolytic, sedative, and/or hypnotic effects of flower extracts in pre-clinical animal models. They found that some flower extracts have an anxiolytic effect comparable to diazepam, but their therapeutic utility in anxiety disorders needs more investigation. The study compiled the characteristics of anxiety studies in animal models, evaluated locomotor activity, and the hypnotic effect of the extracts. The study revealed that matricaria chamomilla had a sedative effect, and 23 other flower plants had anxiolytic effects. However, more reliable behavioral tests and better experimental designs are needed to obtain more conclusive evidence with clinical significance.

Review Neuroscience
Meneses C et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7830
PubMed:
37039741

Biochar mitigates allelopathic effects in temperate trees.

Sujeeun L and Thomas SC (2023).
Ecol Appl.
DOI:
10.1002/eap.2832
PubMed:
36864680

Pharmacological Interaction of Quercetin Derivatives of Tilia americana and Clinical Drugs in Experimental Fibromyalgia.

Quinto-Ortiz YE et al (2022).
Metabolites.
DOI:
10.3390/metabo12100916
PubMed:
36295818

Litter quality and decomposition responses to drought in a northeastern US deciduous forest.

Wilson AM et al (2022).
Oecologia.
DOI:
10.1007/s00442-022-05263-z
PubMed:
36129577

Protective Effect of Tilia americana var. mexicana Against Kainic Acid-induced Damage in Brain, Liver, and Kidney: Behavioral and Biochemical Changes.

Summary

Extracts from var. have been found to possess anticonvulsant properties, but their effectiveness in status epilepticus models has not been well studied. Researchers administered ethyl acetate and methanol extracts of the plant to rats before inducing seizures with kainic acid. Both extracts decreased the severity of seizures and prevented increased lipid peroxidation in various brain areas, kidneys, and liver. The methanol extract also increased the latency to seizure. These effects are likely due to the antioxidant properties of the extracts and their chemical constituents. The vehicle, olive oil, also showed anticonvulsant and antioxidant effects.

Neuroscience
Coballase-Urrutia E et al (2022).
Iran J Pharm Res.
DOI:
10.5812/ijpr-126914
PubMed:
36060909

Organellar microcapture to extract nuclear and plastid DNA from recalcitrant wood specimens and trace evidence.

Genetics
Costa A et al (2022).
Plant Methods.
DOI:
10.1186/s13007-022-00885-z
PubMed:
35443731

A mixture of quercetin 4'-O-rhamnoside and isoquercitrin from Tilia americana var. mexicana and its biotransformation products with antidepressant activity in mice.

Martínez-Hernández GB et al (2021).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2020.113619
PubMed:
33248185

Effect of Standardized Fractions and Tiliroside from Leaves of Tilia americana on Depression Tests in Mice.

Chávez-Morales Y et al (2019).
Iran J Pharm Res.
DOI:
10.22037/ijpr.2019.1100883
PubMed:
32184859

Effects of Elevated CO(2) on Leaf Senescence, Leaf Nitrogen Resorption, and Late-Season Photosynthesis in Tilia americana L.

Li L, Wang X and Manning WJ (2019).
Front Plant Sci.
DOI:
10.3389/fpls.2019.01217
PubMed:
31681356

Hypoglycemic Activity of Tilia americana, Borago officinalis, Chenopodium nuttalliae, and Piper sanctum on Wistar Rats.

Diabetes
Rodríguez-Magaña MP et al (2019).
J Diabetes Res.
DOI:
10.1155/2019/7836820
PubMed:
31179342

Pharmacokinetic Study of Biotransformation Products from an Anxiolytic Fraction of Tilia americana.

Juárez Ramírez VA et al (2017).
Molecules.
DOI:
10.3390/molecules22081260
PubMed:
28749448

Biochemical and molecular modulation of CCl(4)-induced peripheral and central damage by Tilia americana var. mexicanaextracts.

Coballase-Urrutia E et al (2017).
Saudi Pharm J.
DOI:
10.1016/j.jsps.2016.06.008
PubMed:
28344485

Isolated coastal populations of Tilia americana var. caroliniana persist long-term through vegetative growth.

Evans JP and Morris AB (2016).
Am J Bot.
DOI:
10.3732/ajb.1600233
PubMed:
27630119

Neuroprotective effects of Tilia americana var. mexicana on damage induced by cerebral ischaemia in mice.

Summary

This study investigated the effects of Tilia americana var. mexicana on damage caused by cerebral ischaemia in mice. The researchers administered non-polar and polar extracts of the plant immediately after inducing ischaemia. The experimental groups treated with these extracts had improved neurological deficits, increased survival rate, and reduced infarct area compared to the ischaemic group. The study confirms the neuroprotective activity of T. americana, suggests a possible synergism between non-polar and polar constituents, and supports its potential as a useful aid in the clinical management of stroke.

Neuroscience
Angeles-López GE et al (2016).
Nat Prod Res.
DOI:
10.1080/14786419.2015.1110701
PubMed:
26592749

Antinociceptive activity of Tilia americana var. mexicana inflorescences and quercetin in the formalin test and in an arthritic pain model in rats.

ArthritisPain
Martínez AL et al (2009).
Neuropharmacology.
DOI:
10.1016/j.neuropharm.2008.10.010
PubMed:
19027760

American linden, Tilia americana.

Review
Weber RW et al (2002).
Ann Allergy Asthma Immunol.
PubMed:
12027081