Tinospora cordifolia

Ethnobotanical Studies

Clinical Trials

Adhatoda vasica and Tinospora cordifolia extracts ameliorate clinical and molecular markers in mild COVID-19 patients: a randomized open-label three-armed study.

Scientists studied the effects of SARS-CoV-2 infections and found that while most cases are mild, a significant number of infected individuals develop severe respiratory illness. This highlights the need for a safe and effective treatment for COVID-19.

Verma M et al (2023).
Eur J Med Res.
PubMed:
38049897

Studies

Correction: Tinospora cordifolia as a potential neuroregenerative candidate against glutamate induced excitotoxicity: an in vitro perspective.

Sharma A and Kaur G (2024).
BMC Complement Med Ther.
PubMed:
39215304

Assessment of cytoprotective and genoprotective effects of Moringa oleifera and Tinospora cordifolia extracts in vitro.

Bagri P, Kumar V and Batra K (2024).
Toxicol Res (Camb).
PubMed:
39184218

Acute sleep deprivation-induced hepatotoxicity and dyslipidemia in middle-aged female rats and its amelioration by butanol extract of Tinospora cordifolia.

Bajaj P et al (2024).
Lab Anim Res.
PubMed:
39164744

Proteomic Analysis of HepG2 Cells Reveals FAT10 and BAG2 Signaling Pathways Affected by a Protease Inhibitor from Tinospora cordifolia (Willd.) Hook. f. and Thoms Stem. Extract Among the Different Plant and Microbial Samples Analyzed.

Chougule BS et al (2024).
Turk J Pharm Sci.
PubMed:
38994797

Tinospora cordifolia Extract Enhances Dextromethorphan Bioavailability: Implications for Alzheimer's Disease.

Summary

Study investigated stem extract potential improve dextromethorphan bioavailability for Alzheimer's disease management. Network pharmacology analysis showed TCE targeting AD factors, enhancing memory and reducing hyperactivity in rodents.

Majhi PK et al (2024).
ACS Omega.
PubMed:
38854540

Heteroatom-doped carbon dots from medicinal plants as novel biomaterials for as-use biomedical applications in comparison with synthetic drug, zaltoprofen.

Kota S et al (2024).
Sci Rep.
PubMed:
38849424

Indian herb Tinospora cordifolia and Tinospora species: Phytochemical and therapeutic application.

Summary

Scientists reviewed literature on Indian species for their medicinal benefits due to minimal adverse effects. Important medicinal herbs with diverse therapeutic uses for treating various diseases. Further research needed on chemical constitution and pharmacological characteristics of species.

Chaudhary A et al (2024).
Heliyon.
PubMed:
38813196

Determination of genoprotection against cyclophosphamide induced toxicity in bone marrow of Swiss albino mice by Moringa oleifera leaves and Tinospora cordifolia stem.

Bagri P and Kumar V (2024).
J Toxicol Environ Health A.
PubMed:
38804873

Safety and Efficacy of the Ayurvedic Formulation Guduchi Ghana Vati as a Preventive Remedy in COVID-19.

Summary

Guduchi Ghana Vati showed potential as a preventive remedy for COVID-19 and other infections in a healthy population, with lower severity and hospitalization requirements in those taking it. It is safe and effective for preventing infections and boosting immunity.

Sharma S et al (2024).
Cureus.
PubMed:
38784353

Green Synthesis of Reduced Graphene Oxide Using the Tinospora cordifolia Plant Extract: Exploring Its Potential for Methylene Blue Dye Degradation and Antibacterial Activity.

Saini R, Mishra RK and Kumar P (2024).
ACS Omega.
PubMed:
38737070

Anti-dengue therapeutic potential of Tinospora cordifolia and its bioactives.

Review
Singh N and Yadav SS (2024).
J Ethnopharmacol.
PubMed:
38679398

Process Optimization of Tinospora cordifolia Extract-Loaded Water in Oil Nanoemulsion Developed by Ultrasound-Assisted Homogenization.

Anjum V et al (2024).
Molecules.
PubMed:
38675617

A comprehensive review on the hepatotoxicity of herbs used in the Indian (Ayush) systems of alternative medicine.

Review
Philips CA and Theruvath AH (2024).
Medicine (Baltimore).
PubMed:
38640296

Antimicrobial and antibiofilm effect of cannabinoids from Cannabis sativa against methicillin-resistant Staphylococcus aureus (MRSA) causing bovine mastitis.

Summary

Researchers identified Cannabis sativa L. as a potent inhibitor of MRSA, with cannabidiol and Δ9-THC showing bactericidal action. This plant-based alternative may help combat antimicrobial resistance in bovine biofilm-associated MRSA infections.

Roshan M et al (2024).
Int Microbiol.
PubMed:
38568425

Phytosynthesis of zinc oxide nanoparticles for enhanced antioxidant, antibacterial, and photocatalytic properties: A greener approach to environmental sustainability.

Jayaseelan C et al (2024).
Environ Res.
PubMed:
38518913

Ayush [Indian System of Medicines] Prophylaxis Against COVID-19: A Living Systematic Review and Meta-Analysis (Second Update).

Summary

Ayush medicine shows potential for preventing COVID-19 infections. More high-quality studies are needed to confirm efficacy and safety. Policymakers should consider this evidence for decision-making.

Thakar A et al (2024).
J Integr Complement Med.
PubMed:
38422192

Antagonistic properties of Lactiplantibacillus plantarum MYSVB1 against Alternaria alternata: a putative probiotic strain isolated from the banyan tree fruit.

Vasundaradevi R et al (2024).
Front Microbiol.
PubMed:
38404595

Tinospora cordifolia (Giloy): An insight on the multifarious pharmacological paradigms of a most promising medicinal ayurvedic herb.

Review
Gupta A, Gupta P and Bajpai G (2024).
Heliyon.
PubMed:
38390130

Laboratory Assessment of Molluscicidal Activities of Cannabis sativa, Acacia nilotica, and Tinospora cordifolia Against Snail Host of Fasciola spp.

Singh NV, Singh A and Singh VK (2024).
Vector Borne Zoonotic Dis.
PubMed:
38364187

Potential of medicinal plants to ameliorate neovascularization activities in diabetes: A systematic review.

Summary

This review examines the potential of medicinal plants to reduce complications of diabetes caused by excessive angiogenesis. Identified plants lowered blood glucose levels and increased body weight, while also decreasing VEGF protein expression and vasculature activity. They have the potential to ameliorate neovascularization activities in diabetes.

Yong PH et al (2024).
Endocr Regul.
PubMed:
38345496

A study on incorporation of giloy (Tinosporacordifolia) for the development of shelf-stable goat milk based functional beverage.

Sharma H et al (2024).
J Food Sci Technol.
PubMed:
38327858

Traditional uses, hepatoprotective potential, and phytopharmacology of Tinospora cordifolia: a narrative review.

Balkrishna A et al (2024).
J Pharm Pharmacol.
PubMed:
38280221

Antimicrobial and Synergistic Effects of Syzygium cumini, Moringa oleifera, and Tinospora cordifolia Against Different Candida Infections.

Summary

Plant extracts showed strong antimicrobial activity against bacteria and fungi, including drug-resistant strains, and worked well with fluconazole. They could be a sustainable solution for infections.

Adelakun AO et al (2024).
Cureus.
PubMed:
38274587

Protective effects of Tinospora cordifolia miers extract against hepatic and neurobehavioral deficits in thioacetamide-induced hepatic encephalopathy in rats via modulating hyperammonemia and glial cell activation.

Ali SA and Datusalia AK (2024).
J Ethnopharmacol.
PubMed:
38176666

Tinospora cordifolia ameliorates paclitaxel-induced neuropathic pain in albino rats.

Summary

T. cordifolia, a plant used in Ayurvedic medicine, has been effective in treating sciatica pain and diabetic neuropathy.

Joshi P et al (2023).
J Ethnopharmacol.
PubMed:
38072294

Effect of herbal extracts and Saroglitazar on high-fat diet-induced obesity, insulin resistance, dyslipidemia, and hepatic lipidome in C57BL/6J mice.

Summary

Researchers found that TC + PL extract reduced insulin resistance and liver weight in mice, while Saroglitazar reversed body weight and lipid level changes. These extracts hold promise for preventing obesity-related complications.

Kumari D et al (2023).
Heliyon.
PubMed:
38027691

Systematic review and network meta-analysis of efficacy and safety of interventions for preventing anti-tuberculosis drug induced liver injury.

Meta-Analysis
Akkahadsee P et al (2023).
Sci Rep.
PubMed:
37963954

De novo genome assembly and annotation of the medicinal plant Tinospora cordifolia (Willd.) Miers ex Hook. f. & Thom's.

Summary

Scientists sequenced the genome of Tinospora cordifolia and identified genes responsible for the synthesis of syringin, a potential therapeutic compound. Syringin showed strong binding affinity for targets of Parkinson's and Alzheimer's diseases. This research provides valuable genomic information and insights for developing therapeutic drugs.

R N et al (2023).
Funct Integr Genomics.
PubMed:
37935874

Computational Approaches to Designing Antiviral Drugs against COVID-19: A Comprehensive Review.

Summary

This review explores the use of computational techniques and AI in developing antiviral agents for COVID-19. It identifies potential compounds and stresses the need for experimental validation to expedite the search for effective treatments.

Singh MP et al (2023).
Curr Pharm Des.
PubMed:
37916490

Cardioprotective Role of Tinospora cordifolia against Trimethylamine-NOxide and Glucose Induced Stress in Rat Cardiomyocytes.

Summary

Researchers investigated the relationship between gut microbiota, metabolites, and cardiac contractility in type 2 diabetes. They found that dysbiosis of gut microbiota and secretion of metabolites can directly harm cardiac contractility. This information is important for understanding the causes of diabetic cardiomyopathy and improving patient safety.

Singhal S and Rani V (2023).
Cardiovasc Hematol Agents Med Chem.
PubMed:
37907489

Virtual screening and invitro evaluation of cyclooxygenase inhibitors from Tinospora cordifolia using the machine learning tool.

Mathe A et al (2023).
J Biomol Struct Dyn.
PubMed:
37904339

Therapeutic Effect of Tinospora cordifolia (Willd) Extracts on Letrozole-Induced Polycystic Ovarian Syndrome and its Complications in Murine Model.

Summary

The researchers investigated the safety and effectiveness of Tinospora cordifolia (TC) in treating polycystic ovarian syndrome. Understanding its benefits and potential risks can help guide decisions in the lab and improve treatment options for the syndrome.

Rani R, Sharma AK and Chitme HR (2023).
Clin Med Insights Endocrinol Diabetes.
PubMed:
37901891

Unveiling Various Facades of Tinospora cordifolia Stem in Food: Medicinal and Nutraceutical Aspects.

Review
Anjum V et al (2023).
Molecules.
PubMed:
37894552

The Antibacterial Effect of Tinospora Cordifolia (Guduchi) and Its Role in Combating Antimicrobial Resistance.

Summary

Study evaluated antibacterial capabilities of Tinospora cordifolia, a medicinal plant with anti-diabetic, anti-inflammatory, and other properties. Relevant for drug development due to rise in antimicrobial resistance.

Ezhilarasu K et al (2023).
Medeni Med J.
PubMed:
37766582

An Ayurveda approach in the management of avascular necrosis of bilateral hip joint-A case report.

Singh SK, Rajoria K and Sharma S (2023).
J Ayurveda Integr Med.
PubMed:
37741160

Development and validation of novel quality evaluation methods to differentiate two closely related species of Tinospora: A rapid HPTLC and HPLC-based assessment with -MS/MS characterization.

Girme A et al (2023).
J AOAC Int.
PubMed:
37738282

In Vitro Study on Spermicidal Action of Hydro-methanol Extract of Tinospora cordifolia (Willd.) Stem in Rat and Human Sperm: a Comparative Analysis.

Das P et al (2023).
Reprod Sci.
PubMed:
37640890

GC-MS-Guided Antimicrobial Defense Responsive Secondary Metabolites from the Endophytic Fusarium solani Isolated from Tinospora cordifolia and Their Multifaceted Biological Properties.

Summary

The study found that a fungal endophyte from a medicinal plant produces bioactive secondary metabolites, showing antimicrobial activity against human pathogens. These findings suggest potential for developing new antimicrobial drugs.

Uzma F et al (2023).
Appl Biochem Biotechnol.
PubMed:
37610512

Development of DNA markers using next-generation sequencing approach for molecular authentication of Boerhavia diffusa L. and Tinospora cordifolia (Willd.) Miers.

Sharma AR et al (2023).
3 Biotech.
PubMed:
37593204

Neuroprotective Effects of Tinospora cordifolia via Reducing the Oxidative Stress and Mitochondrial Dysfunction against Rotenone-Induced PD Mice.

Summary

TCE extract protected against Parkinson's disease in mice by reducing oxidative stress, improving mitochondrial function, and reducing cell death. TCE could have potential as a neuroprotective treatment for Parkinson's disease.

Dilnashin H et al (2023).
ACS Chem Neurosci.
PubMed:
37579290

Tinospora cordifolia Miers enhances the immune response in mice immunized with JEV-vaccine: A network pharmacology and experimental approach.

Tiwari P et al (2023).
Phytomedicine.
PubMed:
37573808

Characterization, Cytotoxicity and Anti-oxidant Studies of Phytoniosome Loaded with Ethanolic Leaf Extract of Tinospora Cordifolia.

Masilamani SD, Chokkalingam P and Hari R (2023).
Avicenna J Med Biotechnol.
PubMed:
37538243

Removal of organic dyes and free radical assay by encapsulating polyvinylpyrrolidone and Tinospora Cordifolia in dual (Co-Cu) doped TiO(2) nanoparticles.

Thakur N and Thakur N (2023).
Environ Pollut.
PubMed:
37479165

Network pharmacology, molecular docking, and molecular dynamics simulation to elucidate the mechanism of anti-aging action of Tinospora cordifolia.

Review
Bisht A et al (2023).
Mol Divers.
PubMed:
37439907

Natural 3D Extra Cellular Matrix mimicking stem cells seeded decellularized scaffolds as a platform for tendon regeneration.

Niveditha K et al (2023).
J Biomed Mater Res B Appl Biomater.
PubMed:
37204210

Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report.

Review
Andrade RJ et al (2023).
J Hepatol.
PubMed:
37164270

Effect of temperature on hepatitis a virus and exploration of binding mode mechanism of phytochemicals from tinospora cordifolia: an insight into molecular docking, MM/GBSA, and molecular dynamics simulation study.

Moharana M et al (2024).
J Biomol Struct Dyn.
PubMed:
36995189

Exploration of bioactive molecules from Tinospora cordifolia and Actinidia deliciosa as an immunity modulator via molecular docking and molecular dynamics simulation study.

Bagal VK et al (2023).
Nat Prod Res.
PubMed:
36622893

Tinospora cordifolia (Willd.) Hook.f. & Thomson polysaccharides: A review on extraction, characterization, and bioactivities.

Review
Kumar M et al (2023).
Int J Biol Macromol.
PubMed:
36563821

Liver Injury Following Tinospora Cordifolia Consumption: Drug-Induced AIH, or de novo AIH?

Björnsson ES, Navarro VJ and Chalasani N (2022).
J Clin Exp Hepatol.
PubMed:
35068778

Tinospora cordifolia (Willd.) Miers: Protection mechanisms and strategies against oxidative stress-related diseases.

Review Immunology
Arunachalam K, Yang X and San TT (2022).
J Ethnopharmacol.
PubMed:
34509604

Targeting COVID-19 (SARS-CoV-2) main protease through active phytochemicals of ayurvedic medicinal plants - Withania somnifera (Ashwagandha), Tinospora cordifolia (Giloy) and Ocimum sanctum (Tulsi) - a molecular docking study.

Shree P et al (2022).
J Biomol Struct Dyn.
PubMed:
32851919

Chemistry and Pharmacology of Tinospora cordifolia.

Review
Singh D and Chaudhuri PK (2017).
Nat Prod Commun.
PubMed:
30428235

Berberine and Its Role in Chronic Disease.

Review
Cicero AF and Baggioni A (2016).
Adv Exp Med Biol.
PubMed:
27671811