Tinospora crispa

Ethnobotanical Studies

1.

Lambunao, Iloilo, Philippines

Uses: Sinda, Toothache, Stomachache, Diabetes, Birth control, Vomiting blood, Headache, Inaswang

DOI:: 10.3389/fphar.2021.790567
PubMed:: 35082673

2.

Yi people, Mile, Yunnan, China

Uses: Snake bite, traumatic injury

DOI:: 10.1186/s13002-024-00656-1
PubMed:: 38395900

Studies

1.

Three Undescribed Furanoditerpenoids from the Tinospora crispa that Inhibit NO Production.

Van Quoc N et al (2024).; Chem Biodivers.
DOI:: 10.1002/cbdv.202401679
PubMed:: 39136410

2.

Syringin from Tinospora crispa downregulates pro-inflammatory mediator production through MyD88-dependent pathways in lipopolysaccharide (LPS)-induced U937 macrophages.

Immunology

Arshad L et al (2024).; Mol Biol Rep.
DOI:: 10.1007/s11033-024-09722-z
PubMed:: 38990383

3.

In vitro and in vivo studies of the therapeutic potential of Tinospora crispa extracts in osteoarthritis: Targeting oxidation, inflammation, and chondroprotection.

Immunology

Llamasares-Castillo A et al (2024).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2024.118446
PubMed:: 38857679

4.

Structural Revision of Tinotufolins from Tinospora crispa Leaves Guided by Empirical Rules and DFT Calculations.

Nishidono Y and Tanaka K (2024).; J Nat Prod.
DOI:: 10.1021/acs.jnatprod.3c00902
PubMed:: 38358957

5.

One novel alkaloid from the stems of Tinospora crispa.

Huang F et al (2023).; Nat Prod Res.
DOI:: 10.1080/14786419.2023.2272023
PubMed:: 37865970

6.

Exploration of the main active metabolites from Tinospora crispa (L.) Hook. f. & Thomson stem as insulin sensitizer in L6.C11 skeletal muscle cell by integrating in vitro, metabolomics, and molecular docking.

Zuhri UM et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.117296
PubMed:: 37820996

7.

Development and validation of novel quality evaluation methods to differentiate two closely related species of Tinospora: A rapid HPTLC and HPLC-based assessment with -MS/MS characterization.

Girme A et al (2023).; J AOAC Int.
DOI:: 10.1093/jaoacint/qsad110
PubMed:: 37738282

8.

Tinopanoids K-T, clerodane diterpenoids with anti-inflammatory activity from Tinospora crispa.

Immunology

Zhu YL et al (2023).; Bioorg Chem.
DOI:: 10.1016/j.bioorg.2023.106812
PubMed:: 37651894

9.

Evaluation of Chemical Compositions and the Antioxidant and Cytotoxic Properties of the Aqueous Extract of Tri-Yannarose Recipe (Areca catechu, Azadirachta indica, and Tinospora crispa).

Immunology

Sanpinit S et al (2023).; Antioxidants (Basel).
DOI:: 10.3390/antiox12071428
PubMed:: 37507966

10.

Antidiabetic Activity of Combination of Binahong (Anredera cordifolia Ten. Steenis), Cherry (Muntingia calabura L.) and Brotowali (Tinospora crispa L.) Extracts.

Diabetes

Kusriani H et al (2023).; J Pharm Bioallied Sci.
DOI:: 10.4103/jpbs.jpbs_917_21
PubMed:: 37469648

11.

Computational pharmacology profiling of borapetoside C against melanoma.

Bhattacharya K et al (2023).; J Biomol Struct Dyn.
DOI:: 10.1080/07391102.2023.2213333
PubMed:: 37203884

12.

Diterpenoids and Their Glycosides from the Stems of Tinospora crispa with Beta-Cell Protective Activity.

Lam SH et al (2023).; J Nat Prod.
DOI:: 10.1021/acs.jnatprod.3c00114
PubMed:: 37200063

13.

Herb-induced Liver Injury-A Guide to Approach. Lessons from the Tinospora cordifolia (Giloy) Case Series Story.

Nagral A et al (2023).; J Clin Exp Hepatol.
DOI:: 10.1016/j.jceh.2022.11.001
PubMed:: 36950495

14.

Is Tinospora cordifolia Responsible for Drug-induced Liver Injury?

Singh PA and Bajwa N (2024).; Curr Drug Saf.
DOI:: 10.2174/1574886318666230220120343
PubMed:: 36803756

15.

Natural sunlight driven photocatalytic dye degradation by biogenically synthesized tin oxide (SnO(2)) nanostructures using Tinospora crispa stem extract and its anticancer and antibacterial applications.

Cancer

Kaur M et al (2022).; Environ Sci Pollut Res Int.
DOI:: 10.1007/s11356-022-25028-8
PubMed:: 36585593

16.

Interaction of heavy metals in Drosophila melanogaster larvae: Fourier transform infrared spectroscopy and single-cell electrophoresis study.

Saroha B et al (2022).; J Biomol Struct Dyn.
DOI:: 10.1080/07391102.2022.2137587
PubMed:: 36411739

17.

Can Guduchi (Tinospora cordifolia), a well-known ayurvedic hepato-protectant cause liver damage?

Review

Panneer Selvam K et al (2022).; J Ayurveda Integr Med.
DOI:: 10.1016/j.jaim.2022.100658
PubMed:: 36400639

18.

An updated and comprehensive review on the ethnomedicinal uses, phytochemistry, pharmacological activity and toxicological profile of Tinospora crispa (L.) Hook. f. & Thomson.

Review Ethnobotany Phytochemistry

Haque E et al (2022).; Phytochem Rev.
DOI:: 10.1007/s11101-022-09843-y
PubMed:: 36345416

19.

Green Synthesis of Silver Nanoparticles from Aqueous Extract of Tinospora crispa Stems Accelerate Wound Healing in Rats.

Osman Mahmud S et al (2022).; Int J Low Extrem Wounds.
DOI:: 10.1177/15347346221133627
PubMed:: 36325727

20.

Magnoflorine from Tinospora crispa upregulates innate and adaptive immune responses in Balb/c mice.

Ahmad W et al (2022).; Int Immunopharmacol.
DOI:: 10.1016/j.intimp.2022.109081
PubMed:: 35907339

21.

Network pharmacology integrated molecular dynamics reveals the bioactive compounds and potential targets of Tinospora crispa Linn. as insulin sensitizer.

Zuhri UM et al (2022).; PLoS One.
DOI:: 10.1371/journal.pone.0251837
PubMed:: 35737707

22.

Effects of some medicinal plant extracts on dermal papilla cells.

Wisuitiprot V et al (2022).; J Cosmet Dermatol.
DOI:: 10.1111/jocd.15148
PubMed:: 35675125

23.

Probing PXR activation and modulation of CYP3A4 by Tinospora crispa and Tinospora sinensis.

Parveen A et al (2022).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2022.115159
PubMed:: 35245632

24.

Higenamine in Plants as a Source of Unintentional Doping.

Review

Rangelov Kozhuharov V, Ivanov K and Ivanova S (2022).; Plants (Basel).
DOI:: 10.3390/plants11030354
PubMed:: 35161335

25.

Rearranged clerodane diterpenoid from Tinospora crispa.

Parveen A et al (2021).; Nat Prod Res.
DOI:: 10.1080/14786419.2019.1633648
PubMed:: 31242768

26.

Efficiency of Tinospora crispa against Culex quinquefasciatus larva.

Jiraungkoorskul W et al (2019).; Environ Sci Pollut Res Int.
DOI:: 10.1007/s11356-018-2429-9
PubMed:: 29869741

27.

Tinospora crispa (L.) Hook. f. & Thomson: A Review of Its Ethnobotanical, Phytochemical, and Pharmacological Aspects.

Review Ethnobotany Phytochemistry

Ahmad W, Jantan I and Bukhari SN (2016).; Front Pharmacol.
DOI:: 10.3389/fphar.2016.00059
PubMed:: 27047378

28.

The Significance of Tinospora crispa in Treatment of Diabetes Mellitus.

Review Diabetes

Thomas A, Rajesh EK and Kumar DS (2016).; Phytother Res.
DOI:: 10.1002/ptr.5559
PubMed:: 26749336

29.

Tinospora crispa Ameliorates Insulin Resistance Induced by High Fat Diet in Wistar Rats.

Abu MN et al (2015).; Evid Based Complement Alternat Med.
DOI:: 10.1155/2015/985042
PubMed:: 25821506

30.

Hypoglycemic diterpenoids from Tinospora crispa.

Diabetes

Lam SH et al (2012).; J Nat Prod.
DOI:: 10.1021/np200692v
PubMed:: 22283497