Tinospora sinensis

Ethnobotanical Studies

Gongcheng County, Guangxi, China

Uses: Dispel wind, analgesia, relaxing sinew and activating coll

DOI:: 10.1186/s13002-022-00544-6
PubMed:: 35729593

Mizoram, India

Uses: Cancer, malaria, and diabetes

DOI:: 10.1186/s13002-023-00642-z
PubMed:: 38172927

Yi people, Mile, Yunnan, China

Uses: Traumatic injury

DOI:: 10.1186/s13002-024-00656-1
PubMed:: 38395900

Studies

Targeted discovery of clerodane diterpenoids from Tinospora sinensis as immunomodulatory agents.

Immunology

Ao R et al (2024).; Fitoterapia.
DOI:: 10.1016/j.fitote.2024.106174
PubMed:: 39122119

A Review on traditional uses, phytochemistry, pharmacology and clinical application of Tinospora sinensis (Lour.) Merr.

Phytochemistry

Liang Y et al (2024).; Chem Biodivers.
DOI:: 10.1002/cbdv.202302037
PubMed:: 38546704

Tinospora sinensis (Lour.) Merr alkaloid rich extract induces colon cancer cell death via ROS mediated, mTOR dependent apoptosis pathway: "an in-vitro study".

Cancer Phytochemistry

Badavenkatappa Gari S, Nelson VK and Peraman R (2023).; BMC Complement Med Ther.
DOI:: 10.1186/s12906-023-03849-5
PubMed:: 36737760

Can Guduchi (Tinospora cordifolia), a well-known ayurvedic hepato-protectant cause liver damage?

Review

Panneer Selvam K et al (2022).; J Ayurveda Integr Med.
DOI:: 10.1016/j.jaim.2022.100658
PubMed:: 36400639

Molecular Characterization of Tinospora cordifolia (Willd.) Miers Using Novel g-SSR Markers and Their Comparison with EST-SSR and SCoT Markers for Genetic Diversity Study.

Paliwal R et al (2022).; Genes (Basel).
DOI:: 10.3390/genes13112042
PubMed:: 36360279

Traditional Tibetan medicine: therapeutic potential in rheumatoid arthritis.

Review Arthritis

Yu L et al (2022).; Front Pharmacol.
DOI:: 10.3389/fphar.2022.938915
PubMed:: 36267280

Formulation and evaluation of SGLT2 inhibitory effect of a polyherbal mixture inspired from Ayurvedic system of medicine.

Kumar A et al (2022).; J Tradit Complement Med.
DOI:: 10.1016/j.jtcme.2022.03.003
PubMed:: 36081821

Constituents of Tinospora sinensis and their nitric oxide inhibitory activities.

Anh BTM et al (2022).; J Asian Nat Prod Res.
DOI:: 10.1080/10286020.2022.2113975
PubMed:: 36069750

Lignans and clerodane diterpenoids from Tinospora sinensis.

Phytochemistry

Wen C et al (2020).; RSC Adv.
DOI:: 10.1039/d0ra04917d
PubMed:: 35519134

10.

Clerodane furanoditerpenoids from the stems of Tinospora sinensis.

Zhang JS et al (2022).; Arch Pharm Res.
DOI:: 10.1007/s12272-022-01383-5
PubMed:: 35478401

11.

Probing PXR activation and modulation of CYP3A4 by Tinospora crispa and Tinospora sinensis.

Parveen A et al (2022).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2022.115159
PubMed:: 35245632

12.

Diterpenoid glucosides with cystathionine γ-lyase inhibitory activity from Tinospora sinensis.

Zhang JS et al (2021).; Bioorg Chem.
DOI:: 10.1016/j.bioorg.2021.105400
PubMed:: 34627118

13.

Lignans with NO inhibitory activity from Tinospora sinensis.

Phytochemistry

Zhang JS et al (2021).; Chin J Nat Med.
DOI:: 10.1016/S1875-5364(21)60049-3
PubMed:: 34247773

14.

Network pharmacology-based strategy to investigate pharmacological mechanisms of Tinospora sinensis for treatment of Alzheimer's disease.

Summary

Researchers set out to investigate the potential of Tinospora sinensis as a treatment for Alzheimer's disease (AD), a common age-related disease. T. sinensis is a traditional folk medicine in China known for its anti-inflammatory properties. The study used network pharmacology and molecular docking to explore the potential mechanisms of T. sinensis in treating AD. The results suggest that T. sinensis has potential to treat AD through several pathways, including reducing inflammation and amyloid beta toxicity. Further research is needed to fully understand the mechanisms and efficacy of T. sinensis in treating AD.

Neuroscience

Zhou F et al (2020).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2020.112940
PubMed:: 32389853

15.

Undescribed phenylpropanoid and a dimeric sesquiterpenoid possessing a rare cyclobutane ring from Tinospora sinensis.

Parveen A et al (2021).; Nat Prod Res.
DOI:: 10.1080/14786419.2020.1752207
PubMed:: 32306764

16.

A sesquiterpene glycoside and phenylalanine derivatives from Tinospora sinensis.

Phytochemistry

Huang L et al (2019).; Fitoterapia.
DOI:: 10.1016/j.fitote.2019.104247
PubMed:: 31247217

17.

New terpenoid and phenylpropanoid glycosides from Tinospora sinensis.

Phytochemistry

Jiang H et al (2018).; Fitoterapia.
DOI:: 10.1016/j.fitote.2018.10.018
PubMed:: 30339924

18.

Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity.

Lam SH et al (2018).; Molecules.
DOI:: 10.3390/molecules23102541
PubMed:: 30301176