Toddalia asiatica

Ethnobotanical Studies

Studies

Contact Toxicity and Repellent Effects of Essential Oils from Toddalia asiatica against Two Stored-Product Insects.

Zhang YC et al (2024).
Chem Biodivers.
DOI:
10.1002/cbdv.202400818
PubMed:
39110524

Asiaticasics A-O, structurally intriguing coumarins from Toddalia asiatica with potential inflammatory inhibitory activity.

Summary

T. asiatica yielded new prenylated coumarins (asiaticasics A-O), showing anti-inflammatory activity, particularly compound 12. Compound 12 may reduce pyroptosis by inhibiting NLRP3 inflammasome. Morphological observation supported bioactivity evaluation.

Immunology
Song SC et al (2024).
Phytochemistry.
DOI:
10.1016/j.phytochem.2024.114042
PubMed:
38417721

A strategy of accuracy quantification by extending the concentration monitoring coverage based on online double collision energy of ultra-high performance liquid chromatography tandem mass spectrometry: The pharmacokinetics of Toddalia asiatica as a case study.

Summary

Scientists developed a method called ODCE with UHPLC-MS/MS to measure compounds in traditional Chinese medicines. This strategy allows for wider range quantification and is useful for monitoring the effectiveness and safety of TCMs.

Phytochemistry
Wang R et al (2024).
J Chromatogr A.
DOI:
10.1016/j.chroma.2024.464634
PubMed:
38217962

Quantification and discovery of quality markers from Toddalia asiatica by UHPLC-MS/MS coupled with chemometrics.

Wang R et al (2024).
Phytochem Anal.
DOI:
10.1002/pca.3318
PubMed:
38191127

Six new coumarins from the roots of Toddalia asiatica and their anti-inflammatory activities.

Summary

Scientists discovered six new compounds, toddasirins A-F, from Toddalia asiatica roots. The compounds were structurally elucidated and assessed for anti-inflammatory activity. Compounds 1-3 and 6 exhibited significant inhibition of nitric oxide (NO) production in RAW 264.7 cells induced by lipopolysaccharide.

Immunology
He H et al (2023).
Chin J Nat Med.
DOI:
10.1016/S1875-5364(23)60480-7
PubMed:
38035940

Comparing the effects of essential oils and methanolic extracts on the inhibition of Aspergillus flavus and Aspergillus parasiticus growth and production of aflatoxins.

Kaale LD et al (2023).
Mycotoxin Res.
DOI:
10.1007/s12550-023-00490-6
PubMed:
37261704

Natural Coumarin Isomers with Dramatically Different AIE Properties: Mechanism and Application.

Chen SS et al (2023).
ACS Cent Sci.
DOI:
10.1021/acscentsci.3c00012
PubMed:
37252345

Evaluation of the antibacterial activity of selected Kenyan medicinal plant extract combinations against clinically important bacteria.

Odongo EA et al (2023).
BMC Complement Med Ther.
DOI:
10.1186/s12906-023-03939-4
PubMed:
37013533

Chelerythrine Inhibits Stemness of Cancer Stem-Like Cells of Osteosarcoma and PI3K/AKT/mTOR Signal.

Cancer
Chen Z et al (2022).
J Oncol.
DOI:
10.1155/2022/6435431
PubMed:
36131794

In vitro differences in toddalolactone metabolism in various species and its effect on cytochrome P450 expression.

Shan L et al (2022).
Pharm Biol.
DOI:
10.1080/13880209.2022.2108062
PubMed:
35944298

Determination of quality markers for quality control of Zanthoxylum nitidum using ultra-performance liquid chromatography coupled with near infrared spectroscopy.

Phytochemistry
Wang X et al (2022).
PLoS One.
DOI:
10.1371/journal.pone.0270315
PubMed:
35749476

Metabolomics reveals the intervention effect of Zhuang medicine Longzuantongbi granules on a collagen-induced arthritis rat model by using UPLC-MS/MS.

Arthritis
Yao L et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115325
PubMed:
35508204

A Systematic Review of Medicinal Plants of Kenya used in the Management of Bacterial Infections.

Review
Odongo EA et al (2022).
Evid Based Complement Alternat Med.
DOI:
10.1155/2022/9089360
PubMed:
35368751

Comparative Genomics, Phylogenetics, Biogeography, and Effects of Climate Change on Toddalia asiatica (L.) Lam. (Rutaceae) from Africa and Asia.

Genetics
Mutinda ES et al (2022).
Plants (Basel).
DOI:
10.3390/plants11020231
PubMed:
35050119

Antidiabetic with antilipidemic and antioxidant effects of flindersine by enhanced glucose uptake through GLUT4 translocation and PPARγ agonism in type 2 diabetic rats.

Diabetes
Irudayaraj SS et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2021.114883
PubMed:
34861363

Pharmacokinetic and excretion study of eight active constituents in rat by LC-MS/MS after oral administration of the Toddalia asiatica extract.

Qiu J et al (2022).
Anal Biochem.
DOI:
10.1016/j.ab.2021.114407
PubMed:
34637784

A systematic review on traditional medicine Toddalia asiatica (L.) Lam.: Chemistry and medicinal potential.

Review
Zeng Z et al (2021).
Saudi Pharm J.
DOI:
10.1016/j.jsps.2021.05.003
PubMed:
34408540

Effect of Toddalia asiatica extract combined with miR-483 on proliferation, apoptosis and inflammatory factors expression of osteoarthritis chondrocyte.

Immunology
Yan C and Wu J (2020).
Pak J Pharm Sci.
PubMed:
33361019

Compounds from Toddalia asiatica: Immunosuppressant Activity and Absolute Configurations.

Reinhardt JK et al (2020).
J Nat Prod.
DOI:
10.1021/acs.jnatprod.0c00564
PubMed:
33001647

Toddalia asiatica L. - A Rich Source of Phytoconstituents with Potential Pharmacological Actions, an Appropriate Plant for Recent Global Arena.

Review
Alagaraj P and Muthukrishnan S (2020).
Cardiovasc Hematol Agents Med Chem.
DOI:
10.2174/1871525718666200212095756
PubMed:
32048981

Antibacterial mechanism of chelerythrine isolated from root of Toddalia asiatica (Linn) Lam.

He N et al (2018).
BMC Complement Altern Med.
DOI:
10.1186/s12906-018-2317-3
PubMed:
30257662

Antimalarial and safety evaluation of extracts from Toddalia asiatica (L) Lam. (Rutaceae).

Orwa JA et al (2013).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2012.11.034
PubMed:
23207061