Trichosanthes kirilowii

Ethnobotanical Studies

Studies

The multi-herbal decoction SH003 alleviates LPS-induced acute lung injury by targeting inflammasome and extracellular traps in neutrophils.

Kim HI et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155926
PubMed:
39128302

Analgesic Effect of SKI306X on Chronic Postischemic Pain and Spinal Nerve Ligation-Induced Neuropathic Pain in Mice.

Summary

"SKI306X, made from three oriental herbs, reduces neuropathic pain in mice with chronic postischemic pain and spinal nerve ligation. It shows dose-dependent antiallodynic effects by decreasing GFAP levels."

Pain
Quan J et al (2024).
Biomedicines.
DOI:
10.3390/biomedicines12071379
PubMed:
39061952

Antioxidant and Neuroprotective Effects of Seed Oils from Trichosanthes kirilowii and T. laceribractea in Caenorhabditis elegans: A Comparative Analysis and Mechanism Study.

Summary

Seed oils from Maxim and Hayata seeds have strong antioxidant and neuroprotective effects, reducing ROS levels and preventing amyloid β and tau protein aggregation in neuron cells. This research could lead to potential therapies for neurodegenerative diseases like Alzheimer's.

ImmunologyNeuroscience
Wang W et al (2024).
Antioxidants (Basel).
DOI:
10.3390/antiox13070861
PubMed:
39061929

Assembly and evolutionary analysis of the complete mitochondrial genome of Trichosanthes kirilowii, a traditional Chinese medicinal plant.

Genetics
Jiang Z et al (2024).
PeerJ.
DOI:
10.7717/peerj.17747
PubMed:
39035164

First report of Stagonosporopsis cucurbitacearum Causing Gummy Stem Blight on Trichosanthes kirilowii Maxim. in China.

Cui X et al (2024).
Plant Dis.
DOI:
10.1094/PDIS-09-23-1782-PDN
PubMed:
38831589

Structural characterization of polysaccharide from the peel of Trichosanthes kirilowii Maxim and its anti-hyperlipidemia activity by regulating gut microbiota and inhibiting cholesterol absorption.

Gastroenterology
Jing Y et al (2024).
Bioorg Chem.
DOI:
10.1016/j.bioorg.2024.107487
PubMed:
38805910

Extract of Gualou-Xiebai Herb Pair Improves Lipid Metabolism Disorders by Enhancing the Reverse Cholesterol Transport in Atherosclerosis Mice.

Liu Y et al (2024).
Curr Neurovasc Res.
DOI:
10.2174/0115672026308438240405055719
PubMed:
38629368

Network pharmacology analysis and experimental verification of the antithrombotic active compounds of trichosanthis pericarpium (Gualoupi) in treating coronary heart disease.

Summary

Researchers studied the use of Trichosanthis pericarpium in traditional Chinese medicine. TP may help treat symptoms of coronary heart disease by reducing heat, resolving phlegm, promoting Qi, and clearing chest congestion.

Cardiology
Xia KR et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118158
PubMed:
38614263

Effect of GHX02 on an Asthma-Rhinitis Mouse Model Induced by Ovalbumin and Diesel Particulate Matter.

Summary

Study showed GHX02, a herbal extract, effectively reduced inflammation in asthma-rhinitis mice model exposed to fine dust. Potential treatment for asthma patients with rhinitis.

Asthma
Yang WK et al (2024).
J Med Food.
DOI:
10.1089/jmf.2023.K.0080
PubMed:
38608247

Chinese herbal medicine decreases incidence of hepatocellular carcinoma in diabetes mellitus patients with regular insulin management.

Summary

Abstract: Type 2 DM increases risk of HCC due to insulin's pro-cancer effects. Finding preventative therapy for insulin users is crucial for researchers.

Diabetes
Lai HC et al (2024).
World J Gastrointest Oncol.
DOI:
10.4251/wjgo.v16.i3.716
PubMed:
38577471

First Report of Root Rot Caused by Fusarium incarnatum on Mongolian Snake gourd in China.

Yan L et al (2024).
Plant Dis.
DOI:
10.1094/PDIS-07-23-1424-PDN
PubMed:
38356278

A comparative evaluation of the structure, functionality and volatile profiles of Trichosanthes kirilowii seed protein isolates based on different extraction methods.

Peng D et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.138547
PubMed:
38271897

First report of root rot in Trichosanthes kirilowii (Chinese cucumber) caused by Fusarium sulawesiense in China.

Fu M et al (2024).
Plant Dis.
DOI:
10.1094/PDIS-11-23-2403-PDN
PubMed:
38268175

Integrated serum pharmacochemistry and investigation of the anti-influenza A virus pneumonia effect of Qingjin Huatan decoction.

Liu M et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117701
PubMed:
38185258

The Importance of Traditional Chinese Medicine in the Intervention and Treatment of HIV while Considering its Safety and Efficacy.

Shahrajabian MH and Sun W (2023).
Curr HIV Res.
DOI:
10.2174/011570162X271199231128092621
PubMed:
38047360

Elucidating the pharmacodynamic mechanisms of Yuquan pill in T2DM rats through comprehensive multi-omics analyses.

Lei Y et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1282077
PubMed:
38044947

Root Extract of Trichosanthes kirilowii Suppresses Metastatic Activity of EGFR TKI-Resistant Human Lung Cancer Cells by Inhibiting Src-Mediated EMT.

Summary

Researchers investigated the effects of an ethanolic root extract of TK (ETK) on metastatic lung cancer cells resistant to EGFR tyrosine kinase inhibitors. ETK reduced migration and invasion and suppressed EMT by dephosphorylating Src. CuB played a key role in ETK's anti-metastatic activity. ETK could be a potential treatment for EGFR-TKI-resistant lung cancer.

Cancer
Park HJ and Park SH (2023).
Nutr Cancer.
DOI:
10.1080/01635581.2023.2272345
PubMed:
37870977

Effects of SKCPT on Osteoarthritis in Beagle Meniscectomy and Cranial Cruciate Ligament Transection Models.

Kim HM et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241914972
PubMed:
37834419

Molecular identification and development of an infectious cDNA clone of Trichosanthes kirilowii-infecting cucurbit mild mosaic virus.

Genetics
Chen C et al (2023).
Virology.
DOI:
10.1016/j.virol.2023.109891
PubMed:
37826911

Carboxymethyl chitosan-TK resistant starch complex ameliorates type 2 diabetes by regulating the gut microbiota.

Summary

Carboxymethyl chitosan and resistant starch combo improves diabetes control by increasing probiotic growth, suppressing harmful bacteria, and reducing water intake, weight, blood glucose levels, cholesterol, and triglyceride levels in diabetic mice. Gut microbiota diversity was proven.

DiabetesGastroenterology
Pan X et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.126930
PubMed:
37717867

Optimal compatibility proportional screening of Trichosanthis Pericarpium - Trichosanthis Radix and its anti - Inflammatory components effect on experimental zebrafish and coughing mice.

Immunology
Liu P et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117096
PubMed:
37634750

Transcript-wide identification and expression pattern analysis to comprehend the roles of AP2/ERF genes under development and abiotic stress in Trichosanthes kirilowii.

Genetics
Xiong R et al (2023).
BMC Plant Biol.
DOI:
10.1186/s12870-023-04362-0
PubMed:
37430217

Trichosanates A-G and cucurbitacins W-Y, anticomplement monoterpenoids and cucurbitane-type triterpenoids from the pericarps of Trichosanthes kirilowii.

Yang SY et al (2023).
Bioorg Chem.
DOI:
10.1016/j.bioorg.2023.106710
PubMed:
37418785

The Mixture of Natural Products SH003 Exerts Anti-Melanoma Effects through the Modulation of PD-L1 in B16F10 Cells.

Han NR et al (2023).
Nutrients.
DOI:
10.3390/nu15122790
PubMed:
37375695

Qingjin Huatan decoction protects mice against influenza a virus pneumonia via the chemokine signaling pathways.

Liu M et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116745
PubMed:
37336335

First Report of Tomato mottle mosaic virus infecting Chinese snake gourd (Trichosanthes kirilowii) in China.

Jin D et al (2023).
Plant Dis.
DOI:
10.1094/PDIS-01-23-0161-PDN
PubMed:
37157092

Interventions for osteoarthritis pain: A systematic review with network meta-analysis of existing Cochrane reviews.

Review Pain
Smedslund G et al (2022).
Osteoarthr Cartil Open.
DOI:
10.1016/j.ocarto.2022.100242
PubMed:
36475286

Trichosanthes kirilowii Extract Promotes Wound Healing through the Phosphorylation of ERK1/2 in Keratinocytes.

Kim M, Kim JG and Kim KY (2022).
Biomimetics (Basel).
DOI:
10.3390/biomimetics7040154
PubMed:
36278711

Effect of microwave heating on lipid composition, chemical properties and antioxidant activity of oils from Trichosanthes kirilowii seed.

Immunology
Xu L et al (2022).
Food Res Int.
DOI:
10.1016/j.foodres.2022.111643
PubMed:
35940816

A Distinct Tobamovirus Associated With Trichosanthes kirilowii Mottle Mosaic Disease.

Chen C et al (2022).
Front Microbiol.
DOI:
10.3389/fmicb.2022.927230
PubMed:
35801111

Trichosanthes kirilowii lectin ameliorates streptozocin-induced kidney injury via modulation of the balance between M1/M2 phenotype macrophage.

Immunology
Jiandong L et al (2019).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2018.10.060
PubMed:
30396096

Ribosome-inactivating Proteins from Root Tubers and Seeds of Trichosan-thes kirilowii and Other Trichosanthes Species.

Review
Ye X et al (2016).
Protein Pept Lett.
PubMed:
27225069

Trichosanthes kirilowii ameliorates cisplatin-induced nephrotoxicity in both in vitro and in vivo.

Seo CS et al (2015).
Nat Prod Res.
DOI:
10.1080/14786419.2014.952229
PubMed:
25185822