A study was conducted on 23 species under 13 genera of the family Cucurbitaceae to examine trichomes micromorphology using Scanning Electron Microscope (SEM). The study found that the trichomes vary from unicellular to multicellular and differ in shape, texture, and structure. These differences were found significant taxonomically. The findings of the study help in identifying and classifying different species in the family Cucurbitaceae.