Researchers aimed to assess the impact of Trichosanthes tricuspidata methanolic extract (TTME) on seizures in mice induced by pilocarpine and the resulting oxidative stress. Pilocarpine caused seizures and increased lipid peroxidation, hippocampal nitrite content, and decreased antioxidant enzyme levels. TTME administration reduced seizures in a dose-dependent manner and decreased lipid oxidative damage and nitrite-nitrate content, while also restoring enzymatic antioxidant defenses in the hippocampus. TTME also prevented the loss of neuronal cells in the hippocampus region. The study suggests that TTME has anticonvulsant activity and powerful antioxidant potential that can help reduce oxidative stress caused by seizures.