Common Names: red clover
Scientists found estrogenic compounds in clover nectar and honey from different clover species. Red clover cultivars had highest levels. Bee enzymes may convert compounds, affecting honey quality. Research highlights potential health implications.
Scientists evaluated the binding affinities of phytoestrogens from medicinal plants for estrogen receptor β, using a yeast-based fluorescent assay. This can help identify potential treatments for gynecological diseases and assess environmental substances affecting the female reproductive system.
Researchers isolated new diterpenoids from plants, tested their antiproliferative activity on cancer cell lines, and evaluated their phytotoxicity on weeds. Compounds showed promising anti-cancer activity.
This study analyzed the gene family of WRKY transcription factors in a legume forage grass. They identified 59 genes and classified them into three groups. They found that some genes are induced by different abiotic stresses like drought, low temperature, MeJA, and ABA. These findings contribute to understanding stress resistance mechanisms in .
These plants have been traditionally used for preventing and treating diseases like diabetes. They may contain beneficial compounds that could be useful for developing new treatments in the lab.
Researchers found that red clover has several beneficial effects, including anti-inflammatory, antioxidant, and cardiovascular disease prevention. The current method for testing its components is inadequate, and little is known about its regulatory effect on inflammation in porcine macrophages. Further research is needed.
Formononetin, found in legumes and clovers, has shown potential in protecting neurons. It prevents neuronal damage, lowers tau phosphorylation, boosts neurogenesis, increases antioxidant expression, and inhibits inflammation and neurodegeneration. This review explores its biosynthesis and molecular pathways for neuroprotection.
The review article discusses the potential neuroprotective properties of phytoestrogen-isoflavones present in Trifolium pratense (Red clover) for the treatment of neurodegenerative disorders. Studies have shown that Trifolium pratense contains more than 30 isoflavone compounds, including biochanin A, daidzein, formononetin, and genistein. These compounds have been found to exhibit therapeutic efficacy against different neurodegenerative disorders through molecular interactions with estrogenic receptors, anti-inflammatory, anti-oxidative, antiapoptotic, and autophagic inducing mechanisms. The review provides detailed molecular mechanisms and experimental key findings for the clinical use of Trifolium pratense-derived isoflavones for the treatment of neurodegenerative disorders.
This study evaluated the antitumor activity of extracts from three plant species: L., L., and L. Using HPLC-MS analysis, the phytochemical profile of the extracts was determined. In vitro screening revealed that L. extracts had the strongest anticancer and antioxidant effects. In vivo assessment using a mouse model showed that administration of L. and green coffee bean extracts reduced ascites cell viability and oxidative stress in tumor samples. Combining chemotherapy with L. or L. extracts induced lipid peroxidation in tumor cells, decreasing tumor viability. These findings suggest that L. extract, especially, has potential as an anticancer agent when used in combination with chemotherapy.