Uncaria rhynchophylla

Ethnobotanical Studies

Studies

Isolation of new indole alkaloid triglucoside from the aqueous extract of Uncaria rhynchophylla.

Summary

Researchers isolated and characterized new and known compounds from Uncaria rhynchophylla. X-ray diffraction on single crystals provided structural information, improving quality monitoring of botanical raw materials. This helps uncover potential bioactive constituents for traditional medicine.

Phytochemistry
Koseki Y et al (2024).
J Nat Med.
DOI:
10.1007/s11418-024-01836-9
PubMed:
39174720

The beneficial pharmacological effects of Uncaria rhynchophylla in neurodegenerative diseases: focus on alkaloids.

Summary

Summary: Traditional Chinese medicine Gouteng shows neuroprotective benefits in neurodegenerative diseases like Parkinson's and Alzheimer's. Compounds like corynoxine B offer potential for new drug development. Relevant for aging population health.

Review NeurosciencePhytochemistry
Chen L, Liu Y and Xie J (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1436481
PubMed:
39170707

Genome-Wide Identification of Seven in Absentia E3 Ubiquitin Ligase Gene Family and Expression Profiles in Response to Different Hormones in Uncaria rhynchophylla.

Genetics
Lan J et al (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25147636
PubMed:
39062882

Predictive Analysis of Yi-Gai-San's Multifaceted Mechanisms for Tremor-Dominant Parkinson's Disease via Network Pharmacology and Molecular Docking Validation.

Summary

YGS treat tremor-dominant Parkinson's by multiple mechanisms. Components analyzed, selected, standardized. Includes Gouteng, Chaihu, Chuanxiong, Danggui, Fuling, Baizhu, Gancao. Important for Parkinson's research and treatment.

Neuroscience
Lin CT, Wu LY and Tsai FS (2024).
Curr Med Chem.
DOI:
10.2174/0109298673291838240311075415
PubMed:
38879763

Soil conditioner improves soil properties, regulates microbial communities, and increases yield and quality of Uncaria rhynchophylla.

Liu Q et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-64362-4
PubMed:
38862626

The TLR4/NF-κB/NLRP3 and Nrf2/HO-1 pathways mediate the neuroprotective effects of alkaloids extracted from Uncaria rhynchophylla in Parkinson's disease.

Summary

Alkaloids from Uncaria rhynchophylla show promise in treating Parkinson's disease by reducing inflammation and oxidative stress. Understanding their mechanism could lead to new therapies.

ImmunologyNeurosciencePhytochemistry
Zhang C et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118391
PubMed:
38797377

Alkaloids in Uncaria rhynchophylla improves AD pathology by restraining CD4(+) T cell-mediated neuroinflammation via inhibition of glycolysis in APP/PS1 mice.

Summary

UR and URA from Uncaria rhynchophylla show neuroprotective effects for Alzheimer's and other CNS diseases. Mechanisms not fully understood.Important for potential medical treatments.

ImmunologyNeurosciencePhytochemistry
Kuang Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118273
PubMed:
38703874

Elucidating the anti-hypertensive mechanisms of Uncaria rhynchophylla-Alisma plantago-aquatica L: an integrated network pharmacology, cluster analysis, and molecular docking approach.

Yin T et al (2024).
Front Chem.
DOI:
10.3389/fchem.2024.1356458
PubMed:
38496269

Corynoxine triggers cell death via activating PP2A and regulating AKT-mTOR/GSK3β axes in NSCLC.

Hou G et al (2024).
Biochem Pharmacol.
DOI:
10.1016/j.bcp.2024.116110
PubMed:
38460908

The basic chemical substances of total alkaloids of Uncaria rhynchophylla and their anti-neuroinflammatory activities.

Summary

Scientists identified new alkaloids in , which showed promising anti-neuroinflammatory effects by inhibiting NO production in microglial cells. Compounds , , , , , , and were particularly effective, with IC values of 5.87-76.78 M.

NeurosciencePhytochemistry
Qin JX et al (2024).
J Asian Nat Prod Res.
DOI:
10.1080/10286020.2024.2315211
PubMed:
38373226

Effect of nitrogen reduction by chemical fertilization with green manure (Vicia sativa L.) on soil microbial community, nitrogen metabolism and and yield of Uncaria rhynchophylla by metagenomics.

Yang W et al (2024).
Arch Microbiol.
DOI:
10.1007/s00203-024-03839-2
PubMed:
38363349

Advanced researches of traditional uses, phytochemistry, pharmacology, and toxicology of medical Uncariae Ramulus Cum Uncis.

Summary

Medical Uncariae Ramulus Cum Uncis (URCU) is a plant consisting of various Uncaria species widely used in traditional remedies. URCU extracts have shown neuroprotective, antioxidant, anti-inflammatory, anticancer, antibacterial, and autophagy-enhancer properties in pharmacological studies.

Review Phytochemistry
Cao R et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117848
PubMed:
38336181

Genome-wide identification of GATA transcription factor family and the effect of different light quality on the accumulation of terpenoid indole alkaloids in Uncaria rhynchophylla.

GeneticsPhytochemistry
Shao Y et al (2024).
Plant Mol Biol.
DOI:
10.1007/s11103-023-01400-1
PubMed:
38329633

Evaluation of Reference Genes for Normalizing RT-qPCR and Analysis of the Expression Patterns of WRKY1 Transcription Factor and Rhynchophylline Biosynthesis-Related Genes in Uncaria rhynchophylla.

Summary

Researchers found that S-adenosylmethionine decarboxylase is the most stable reference gene in a medicinal herb, with potential to enhance alkaloid production through synthetic biology.

Genetics
Mu D et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms242216330
PubMed:
38003520

Identification of Uncaria rhynchophylla in the Potential Treatment of Alzheimer's Disease by Integrating Virtual Screening and In Vitro Validation.

Summary

Gouteng shows potential for treating Alzheimer's by reversing tau hyperphosphorylation and offering neuroprotective effects, according to network pharmacology and molecular docking. Care should be taken as it may be a therapeutic option for AD.

Neuroscience
Jiang S et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms242015457
PubMed:
37895137

Minor alkaloids from an aqueous extract of the hook-bearing stem of Uncaria rhynchophylla.

Summary

Scientists isolated seven new monoterpene alkaloids and 16 known analogues from a plant. They determined their structures using spectroscopic analysis and X-ray diffraction. The compounds have unique structures and belong to a novel type of alkaloids.

Phytochemistry
Zhang Q et al (2023).
J Asian Nat Prod Res.
DOI:
10.1080/10286020.2023.2273807
PubMed:
37888783

Supercritical fluid-based method for selective extraction and analysis of indole alkaloids from Uncaria rhynchophylla.

Summary

Researchers developed a method using supercritical fluid extraction and chromatography to separate and identify indole alkaloids in Uncaria rhynchophylla. This method improves specificity and allows for the analysis of alkaloids in complex samples.

Phytochemistry
Fu Q et al (2023).
J Chromatogr A.
DOI:
10.1016/j.chroma.2023.464410
PubMed:
37776825

Efficacy and mechanism study of Baichanting compound, a combination of Acanthopanax senticosus (Rupr. and Maxim.) Harms, Paeonia lactiflora Pall and Uncaria rhynchophylla (Miq.) Miq. ex Havil, on Parkinson's disease based on metagenomics and metabolomics.

Summary

Researchers investigated the potential of Baichanting Compound (BCT), a Chinese herbal prescription, to treat Parkinson's disease (PD). BCT contains Acanthopanax senticosus, Paeonia lactiflora, and Uncaria rhynchophylla. This study may provide insights into a novel treatment option for PD.

Neuroscience
Lu Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117182
PubMed:
37714224

Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease.

Summary

Scientists found that Corynoxine B (Cory B), a natural alkaloid, enhances autophagy to promote clearance of abnormal protein aggregates in Parkinson's disease. Cory B binds to HMGB1/2, increases Beclin 1/VPS34 complex activity, and improves behavioral abnormalities in PD animal models, suggesting its neuroprotective potential.

Neuroscience
Zhu Q et al (2023).
Acta Pharm Sin B.
DOI:
10.1016/j.apsb.2023.03.011
PubMed:
37425041

Discovery and Biomimetic Semisynthesis of Spirophyllines A-D from Uncaria rhynchophylla.

Zhou HF et al (2023).
Org Lett.
DOI:
10.1021/acs.orglett.3c01342
PubMed:
37288843

Anticancer efficacy of hirsuteine against colorectal cancer by opposite modulation of wild-type and mutant p53.

Summary

This study investigates the potential of hirsuteine, an indole alkaloid found in a traditional Chinese herbal medicine called Uncaria rhynchophylla, as an anticancer agent for colorectal cancer (CRC). The researchers aim to understand how HST works against CRC and its underlying mechanism. This research is important as it may provide insight into new treatment options for CRC, a common and potentially deadly cancer.

CancerGastroenterology
Zhang Y et al (2023).
Discov Oncol.
DOI:
10.1007/s12672-023-00688-1
PubMed:
37256374

Study on material basis and anti-hypertensive metabolomics of different extraction methods of the Uncaria rhynchophylla Scrophularia Formula.

Li H et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115464
PubMed:
37209496

Rhynchophylline inhibits methamphetamine dependence via modulating the miR-181a-5p/GABRA1 axis.

Jiang MJ et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116635
PubMed:
37182675

Carboxymuconolactone decarboxylase is a prospective molecular target for multi-drug resistant Acinetobacter baumannii-computational modeling, molecular docking and dynamic simulation studies.

Rana S et al (2023).
Comput Biol Med.
DOI:
10.1016/j.compbiomed.2023.106793
PubMed:
36944292

Rhynchophylline alleviates neuroinflammation and regulates metabolic disorders in a mouse model of Parkinson's disease.

Summary

Researchers studied the effects of Rhynchophylline (RIN), a compound with anti-inflammatory and neuroprotective properties, on a mouse model of Parkinson's disease (PD). They used a combination of tests and assays to determine that RIN improved behavior, reduced neuron loss, and regulated metabolic disorders in the mice. The study showed that RIN has potential as a therapeutic agent for PD by reducing inflammation, maintaining metabolic balance, and suppressing certain proteins in the brain.

ImmunologyNeuroscience
Zhang C et al (2023).
Food Funct.
DOI:
10.1039/d2fo02939a
PubMed:
36919954

Antidepressive mechanisms of rhynchophylline in mice with chronic unpredictable stress-induced depression.

Liu EY et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116302
PubMed:
36842720

Optimization of Isolation and Transformation of Protoplasts from Uncaria rhynchophylla and Its Application to Transient Gene Expression Analysis.

Shao Y et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24043633
PubMed:
36835049

Isorhynchophylline ameliorates stress-induced emotional disorder and cognitive impairment with modulation of NMDA receptors.

Summary

Researchers investigated the effects of isorhynchophylline on stress-induced emotional disorders and cognitive impairment. They conducted experiments on mice, observing their cognitive abilities and emotional responses under stress. The study found that isorhynchophylline had positive effects on both emotional and cognitive functions, suggesting a potential therapeutic use for humans. Further studies should explore this possibility.

Neuroscience
Wang C et al (2022).
Front Neurosci.
DOI:
10.3389/fnins.2022.1071068
PubMed:
36590289

Gene coexpression networks allow the discovery of two strictosidine synthases underlying monoterpene indole alkaloid biosynthesis in Uncaria rhynchophylla.

Phytochemistry
Jiang CX et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2022.11.249
PubMed:
36442554

Uncariphyllin A-J, indole alkaloids from Uncaria rhynchophylla as antagonists of dopamine D2 and Mu opioid receptors.

Summary

Researchers isolated ten new indole alkaloids from the Uncaria rhynchophylla plant, as well as eleven known analogs. These compounds were evaluated for their bioactivity on dopamine D2 and Mu opioid receptors. Two compounds showed significant antagonistic activity on both receptors, making them promising for developing natural therapeutic drugs for central nervous system diseases.

NeurosciencePhytochemistry
Xu Y et al (2023).
Bioorg Chem.
DOI:
10.1016/j.bioorg.2022.106257
PubMed:
36375349

Traditional uses, chemical compounds, pharmacological activities and clinical studies on the traditional Chinese prescription Yi-Gan San.

Review
Yang SY et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115859
PubMed:
36280017

Dual modulators of aggregation and dissociation of amyloid beta and tau: In vitro, in vivo, and in silico studies of Uncaria rhynchophylla and its bioactive components.

Kim S et al (2022).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2022.113865
PubMed:
36242849

Soil Heavy Metal Content and Enzyme Activity in Uncaria rhynchophylla-Producing Areas under Different Land Use Patterns.

Yang X et al (2022).
Int J Environ Res Public Health.
DOI:
10.3390/ijerph191912220
PubMed:
36231522

Uncaria rhynchophylla mediated Ag/NiO nanocomposites: A new insight for the evaluation of cytotoxicity, antibacterial and photocatalytic applications.

Khan AU et al (2022).
Photodiagnosis Photodyn Ther.
DOI:
10.1016/j.pdpdt.2021.102681
PubMed:
34915183

The Main Alkaloids in Uncaria rhynchophylla and Their Anti-Alzheimer's Disease Mechanism Determined by a Network Pharmacology Approach.

Summary

This study used a network pharmacology approach to investigate the potential of certain alkaloids found in Uncaria Rhynchophylla (UR) for treating Alzheimer's disease (AD). The researchers identified 10 alkaloids that corresponded to 90 anti-AD targets. They found that corynoxine, corynantheine, isorhynchophylline, dihydrocorynatheine, and isocorynoxeine are likely to become key components for AD treatment. KEGG pathway enrichment analysis revealed that the Alzheimer's disease pathway was the most significantly enriched in alkaloids against AD. The study also found that UR alkaloids directly exert an AD treatment effect by acting on multiple pathological processes in AD. These findings suggest that UR alkaloids could be further studied as potential treatments for AD.

NeurosciencePhytochemistry
Zeng P et al (2021).
Int J Mol Sci.
DOI:
10.3390/ijms22073612
PubMed:
33807157

Uncaria rhynchophylla ameliorates unpredictable chronic mild stress-induced depression in mice via activating 5-HT(1A) receptor: Insights from transcriptomics.

Summary

Researchers conducted a study to determine if Uncaria rhynchophylla could be effective in treating depression. They induced depression in rats and then administered the herb to some while providing a placebo to others. The rats treated with the herb showed a decrease in depression-like symptoms and an increase in the neurotransmitter serotonin. The study suggests that the herb may be a useful treatment option for depression. However, further research is needed to determine its efficacy in humans.

GeneticsNeuroscience
Qiao YL et al (2021).
Phytomedicine.
DOI:
10.1016/j.phymed.2020.153436
PubMed:
33360346

Uncaria rhynchophylla and its Major Constituents on Central Nervous System: A Review on Their Pharmacological Actions.

Summary

This study looked at the potential benefits of the herb Uncaria rhynchophylla in treating conditions affecting the central nervous system. This herb is commonly used in Chinese medicine to treat convulsions, hypertension, epilepsy, and other cerebral diseases. Researchers focused on the active components of the herb, including alkaloids, terpenoids, and flavonoids. The study found that U. rhynchophylla had protective effects on the CNS, supporting its use in traditional medicine. These findings suggest that the herb may have potential as a natural remedy for certain neurological conditions. Overall, further research is needed to fully understand the benefits of U. rhynchophylla for human health.

Review Neuroscience
Yang W et al (2020).
Curr Vasc Pharmacol.
DOI:
10.2174/1570161117666190704092841
PubMed:
31272356

Mechanisms of Action of Uncaria rhynchophylla Ethanolic Extract for Its Vasodilatory Effects.

Loh YC et al (2017).
J Med Food.
DOI:
10.1089/jmf.2016.3804
PubMed:
28771084

Uncaria rhynchophylla induces angiogenesis in vitro and in vivo.

Genetics
Choi DY et al (2005).
Biol Pharm Bull.
PubMed:
16327159