Vaccinium macrocarpon

Common Names: American cranberry, cranberry, large cranberry

Ethnobotanical Studies

Clinical Trials

Alternative Approaches for the Management of Urinary Tract Infection with Crano-cure: A Randomized Clinical Trial.

Ur Rehman J et al (2024).
Altern Ther Health Med.
PubMed:
39110045

Segmental Acupuncture for Prevention of Recurrent Urinary Tract Infections. A Randomised Clinical Trial.

Ots T et al (2024).
Int Urogynecol J.
PubMed:
39060726

Supplementation with Highly Standardized Cranberry Extract Phytosome Achieved the Modulation of Urinary Tract Infection Episodes in Diabetic Postmenopausal Women Taking SGLT-2 Inhibitors: A RCT Study.

"Cranberry extract may reduce UTI recurrence in diabetic postmenopausal women taking SGLT-2 inhibitors. No impact on glycemic control or quality of life. Consider supplement for prevention."

Rondanelli M et al (2024).
Nutrients.
PubMed:
38999860

Randomized, placebo-controlled, double-blinded study of prophylactic cranberries use in women with recurrent uncomplicated cystitis.

Tsiakoulias E et al (2024).
World J Urol.
PubMed:
38214795

Antibiotic versus cranberry in the treatment of uncomplicated urinary infection: a randomized controlled trial.

Study tested the impact of cranberry extract on patients with one urinary tract infection. Important because it provides insight into the potential benefits of cranberry extract in treating UTIs.

Güven O et al (2023).
Rev Assoc Med Bras (1992).
PubMed:
38126412

Unravelling phenolic metabotypes in the frame of the COMBAT study, a randomized, controlled trial with cranberry supplementation.

Cranberry consumption affects plasma and urine metabolites, with variations among individuals. Three phenolic metabotypes were identified, mainly driven by colonic metabolism. This innovative approach helps understand (poly)phenol metabolism and individual differences, contributing to studying the health effects of cranberries and other (poly)phenol-rich foods.

Tosi N et al (2023).
Food Res Int.
PubMed:
37689939

Polyphenol-Rich Beverage Consumption Affecting Parameters of the Lipid Metabolism in Healthy Subjects.

This study found that consuming a polyphenol-rich beverage (PRB) can decrease fat and protein intake, increase fat-free mass, and improve DNA integrity. It has potential benefits for lipid metabolism.

Rahn C et al (2023).
Int J Mol Sci.
PubMed:
36614281

Cranberry-lingonberry juice affects the gut and urinary microbiome in children - a randomized controlled trial.

Cranberry juice alters urinary microbiome in children with UTIs, reducing Proteobacteria and increasing Firmicutes, potentially preventing infections. Drinking cranberry juice may be beneficial for UTI prevention.

Hakkola M et al (2023).
APMIS.
PubMed:
36602283

Predictive models built upon annotated and validated intake biomarkers in urine using paired or unpaired analysis helped to classify cranberry juice consumers in a randomized, double-blinded, placebo-controlled, and crossover study.

Zhao S et al (2023).
Nutr Res.
PubMed:
36587538

A Multicenter, Randomized, Placebo-Controlled Study Evaluating the Efficacy of a Combination of Propolis and Cranberry (Vaccinium macrocarpon) (DUAB®) in Preventing Low Urinary Tract Infection Recurrence in Women Complaining of Recurrent Cystitis.

Bruyère F et al (2019).
Urol Int.
PubMed:
31117097

Standardised high dose versus low dose cranberry Proanthocyanidin extracts for the prevention of recurrent urinary tract infection in healthy women [PACCANN]: a double blind randomised controlled trial protocol.

Asma B et al (2018).
BMC Urol.
PubMed:
29716563

Studies

Sparganothis sulfureana (Lepidoptera: Tortricidae) egg surface characteristics stimulate parasitism by Ascogaster mimetica (Hymenoptera: Braconidae).

Ben-Zvi Y and Rodriguez-Saona C (2024).
J Insect Sci.
PubMed:
39243220

Cranberry Products for Preventing Urinary Tract Infections.

Johari F and Johari P (2024).
Am Fam Physician.
PubMed:
39028775

Genotypic Variation and Potential Mechanisms of Resistance against Multiple Insect Herbivores in Cranberries.

Salazar-Mendoza P et al (2024).
J Chem Ecol.
PubMed:
39028464

Effect of tablets containing a paraprobiotic strain and the cranberry extract on caries incidence in preschool children: A randomized controlled trial.

Olczak-Kowalczyk D et al (2024).
Dent Med Probl.
PubMed:
39023333

Current state and novel outlook on prevention and treatment of rising antibiotic resistance in urinary tract infections.

Summary

Scientists are working on novel drugs and technologies to combat antibiotic-resistant bacteria causing serious UTIs. Promising options include siderophoric cephalosporins, cranberry extract, probiotics, and nanotechnology solutions. More research is needed for efficacy and safety evaluation.

Sher EK et al (2024).
Pharmacol Ther.
PubMed:
38972453

Evaluation of flexural strength and microhardness in Vaccinium macrocarpon (cranberry)-added self-cure polymethyl methacrylate dental resin: An in vitro study.

Anitha KV and Krishnan R (2024).
J Indian Prosthodont Soc.
PubMed:
38946510

Ficus carica L. (Fig) promotes nerve regeneration in a mouse model of sciatic nerve crush.

Sugita S et al (2024).
FEBS Open Bio.
PubMed:
38942739

Comparative In Vitro Study: Assessing Phytochemical, Antioxidant, Antimicrobial, and Anticancer Properties of Vaccinium macrocarpon Aiton and Vaccinium oxycoccos L. Fruit Extracts.

Summary

Study investigated phytochemicals in and fruits, finding cranberry extracts had higher antioxidant activity and inhibited bacterial growth. Cranberry fruit extracts also showed cytotoxicity against prostate and renal cancer cells, suggesting potential for natural remedies in bacterial infections and cancer therapy.

Šedbarė R et al (2024).
Pharmaceutics.
PubMed:
38931857

Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus mutans: a systematic review of in vitro studies.

Summary

Flavonoids in grape seed extract and cranberry show potential to impact Streptococcus mutans activity, could lead to new ways to combat oral bacteria.

Castellanos JS et al (2024).
BMC Oral Health.
PubMed:
38840232

Characteristics of Urinary Tract Infections and the Use of Cranberry Products in Patients With Urinary Diversions: A Narrative Review.

Review
Droste LR and Ratliff CR (2024).
J Wound Ostomy Continence Nurs.
PubMed:
38820218

Effects of Cranberry Extract (Vaccinium macrocarpon) Supplementation on Lipid Peroxidation and Inflammation in Patients with Chronic Kidney Disease (Stages 3-4): A Randomized Controlled Trial.

de Souza Gouveia Moreira L et al (2024).
J Nutr Metab.
PubMed:
38752013

Cranberries for prevention of UTIs.

Young J, Allan GM and Thomas BS (2024).
Can Fam Physician.
PubMed:
38744510

Gelatin/agar pH-indicator film based on cranberry extract loaded with linalool nanoparticle: Survey on physical, antimicrobial, and antioxidant properties.

Summary

Scientists encapsulated linalool in nanoparticles and incorporated them into pH-sensitive smart films with cranberry extract. This enhanced antimicrobial and antioxidant properties, increased water resistance, and improved film strength, preventing pork spoilage.

Song X et al (2024).
Int J Biol Macromol.
PubMed:
38657918

Cranberry Polyphenols and Prevention against Urinary Tract Infections: New Findings Related to the Integrity and Functionality of Intestinal and Urinary Barriers.

González de Llano D et al (2024).
J Agric Food Chem.
PubMed:
38651941

The Effects of Cranberry Consumption on Glycemic and Lipid Profiles in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Summary

Study found cranberry consumption decreased TC/HDL-C ratio and HOMA-IR in humans, suggesting potential lipid-lowering and hypoglycemic properties. Subgroup analysis showed dried forms may decrease fasting insulin. Consider incorporating cranberry for metabolic health.

Meta-Analysis Diabetes
Li X et al (2024).
Nutrients.
PubMed:
38542695

Development and characterization of cranberry pomace extract incorporated and vitamin E fortified edible films as an edible separation sheet for fruit leather.

Jung J, Loe CC and Zhao Y (2024).
J Food Sci.
PubMed:
38532702

Nephroprotective effect of cranberry (Vaccinium oxycoccos) in streptozocin-induced diabetic nephropathy in mice.

Summary

This study looked at the protective effects of in diabetic nephropathy in mice. It is important because diabetic nephropathy is a leading cause of death, especially in those with kidney problems.

Shareef SM, Khaleel RA and Maryoosh TM (2024).
Drug Metab Pers Ther.
PubMed:
38469711

Health Care Workers Online YouTube Content Compared to AUA Prevention of Recurrent Urinary Tract Infections in Women Guidelines: An Integrative Review of Quality and Comprehensiveness Analysis.

Review
Bondok M et al (2024).
Urol Pract.
PubMed:
38447214

A new UHPLC-HRMS metabolomics approach for the rapid and comprehensive analysis of phenolic compounds in blueberry, raspberry, blackberry, cranberry and cherry fruits.

Kodikara C et al (2024).
Food Chem.
PubMed:
38394909

A biofertilizing fungal endophyte of cranberry plants suppresses the plant pathogen Diaporthe.

Thimmappa BC et al (2024).
Front Microbiol.
PubMed:
38371935

Assessing the Gut Microbiota's Ability to Metabolize Oligomeric and Polymeric Flavan-3-ols from Aronia and Cranberry.

Lessard-Lord J et al (2024).
Mol Nutr Food Res.
PubMed:
38350729

Intestinal Microbiome Metabolism of Cranberry (Vaccinium macrocarpon) Proanthocyanidin Dimers, but Not Trimers, Is Altered by Dysbiosis in Ulcerative Colitis Ex Vivo.

Summary

Cranberries have chemical variations that affect how they are metabolized by gut bacteria. Healthy microbiomes produce more beneficial compounds from cranberries than ulcerative colitis microbiomes. The metabolism of a specific cranberry compound called procyanidin B2 is key for this difference.

Diaz MS, Mertens-Talcott SU and Talcott ST (2024).
J Agric Food Chem.
PubMed:
38350030

Quantitative Trait Loci Analysis and Marker Development for Fruit Rot Resistance in Cranberry Shows Potential Genetic Association with Epicuticular Wax.

Kawash J et al (2024).
Phytopathology.
PubMed:
38281162

Identification of antiviral phytochemicals from cranberry as potential inhibitors of SARS-CoV-2 main protease (M(pro)).

Summary

Researchers identified cranberry phytochemicals with antiviral activity against SARS-CoV-2 main protease. Lead compounds were cyanidin 3-O-galactoside, β-carotene, and epicatechin. Cyanidin showed the highest inhibitory potential. Cranberry extracts containing anthocyanins also exhibit potential. Used for therapeutic interventions against SARS-CoV-2.

Pillai U J et al (2024).
Int J Biol Macromol.
PubMed:
38266830

Extraction-depended and thermally-modulated physical and chemical properties of powders produced from cranberry pomace extracts.

Brzezowska J et al (2023).
Curr Res Food Sci.
PubMed:
38259423

Effects of Vaccinium berries (blueberries, cranberries and bilberries) on oxidative stress, inflammation, exercise performance, and recovery - a systematic review.

Summary

A review found that (poly)phenols in berries do not significantly improve exercise performance or recovery in healthy individuals. Limited evidence suggests they may not impact markers of inflammation and oxidative stress. Further studies are needed to understand their effects.

Review Immunology
Prieto Martínez A et al (2024).
Food Funct.
PubMed:
38165220

Unveiling the evolutionary history of lingonberry (Vaccinium vitis-idaea L.) through genome sequencing and assembly of European and North American subspecies.

Hirabayashi K, Debnath SC and Owens GL (2023).
G3 (Bethesda).
PubMed:
38142435

Can cranberry products be used to prevent UTIs?

Jordan V et al (2023).
J Prim Health Care.
PubMed:
38112708

In Vitro Analysis of Selected Antioxidant and Biological Properties of the Extract from Large-Fruited Cranberry Fruits.

Balawejder M et al (2023).
Molecules.
PubMed:
38067623

Chemical Composition and Insulin-Resistance Activity of Arginine-Loaded American Cranberry (Vaccinium macrocarpon Aiton, Ericaceae) Leaf Extracts.

Koshovyi O et al (2023).
Pharmaceutics.
PubMed:
38004508

The effects of blueberry and cranberry supplementation on blood pressure in patients with cardiovascular diseases: A systematic review and meta-analysis of randomized clinical trials.

Summary

This meta-analysis reviewed studies on blueberry and cranberry supplementation in patients with cardiometabolic diseases and their effects on blood pressure. Results show that while some studies found significant reductions in blood pressure, pooled results showed neutral effects. Additional high-quality studies are necessary to determine clinical efficacy.

Meta-Analysis Cardiology
Delpino FM et al (2024).
Phytother Res.
PubMed:
37963472

[Use of cranberries to prevent urinary tract infections : Commentary on the Cochrane review].

Schreen W and Zengerling F (2023).
Urologie.
PubMed:
37949976

Edible Gels with Cranberry Extract: Evaluation of Anthocyanin Release Kinetics.

Šedbarė R, Janulis V and Ramanauskiene K (2023).
Gels.
PubMed:
37888369

Tranebær og recidiverende urinvejsinfektioner.

Frimodt-Møller N et al (2023).
Ugeskr Laeger.
PubMed:
37767869

Comparative clinical evaluation of a local drug delivery of cranberry and garcinia fruit gel with tetracycline fibers for amelioration of periodontitis: A split mouth study.

Panda V et al (2023).
J Indian Soc Periodontol.
PubMed:
37593560

Peculiarities of the Variation of Biologically Active Compounds in Fruit of Vaccinium oxycoccos L. Growing in the Čepkeliai State Strict Nature Reserve.

Šedbarė R, Grigaitė O and Janulis V (2023).
Molecules.
PubMed:
37570858

Literature Review of Ascorbic Acid, Cranberry, and D-mannose for Urinary Tract Infection Prophylaxis in Older People.

Review
Song G et al (2023).
Sr Care Pharm.
PubMed:
37496168

Assessment and comparison of rhizosphere communities in cultivated Vaccinium spp. provide a baseline for study of causative agents in decline.

Kawash J et al (2023).
Front Plant Sci.
PubMed:
37441173

(1)H-(13)C HSQC-NMR Analysis of Cranberry (Vaccinium Macrocarpon) Juice Defines the Chemical Composition of Juice Precipitate.

Dorris MR, Zeller WE and Bolling BW (2023).
J Agric Food Chem.
PubMed:
37431749

The effect of ascorbic acid and cranberry on the bond strength, surface roughness, and surface hardness of bleached enamel with hydrogen peroxide and zinc phthalocyanine activated by photodynamic therapy.

Alanazi AM et al (2023).
Photodiagnosis Photodyn Ther.
PubMed:
37390856

The Protective Role of Cranberries and Blueberries in Oral Cancer.

Summary

Oral cancer, a prevalent global disease, is influenced by genetic, immunological, and environmental factors. Smoking and alcohol consumption are the main risk factors associated with oral cancer. Understanding these factors is essential in preventing and treating this deadly disease.

Review Cancer
Esquivel-Chirino C et al (2023).
Plants (Basel).
PubMed:
37375955

Say 'No' to Cancer and 'Yes' to Cranberry: The Role of Cranberry Extract in Inhibition of Growth of Lung Adenocarcinoma Cells.

Summary

This study explores the potential of cranberry in treating lung adenocarcinoma (LUAD), a challenging form of lung cancer. While cranberry's anti-cancer properties have been studied in other cancer types, its effectiveness against LUAD remains unclear. The research aims to expand our understanding of cranberry's role in LUAD treatment. As the leading cause of cancer-related deaths, finding new approaches to combat lung cancer is of great significance.

Zhao L et al (2023).
Anticancer Res.
PubMed:
37351982

Microbiome of Ceca from Broiler Chicken Vaccinated or Not against Coccidiosis and Fed Berry Pomaces.

Yang C et al (2023).
Microorganisms.
PubMed:
37317158

A Labor of Love: From Cranberry Biologist to Nurse Scholar and Educator.

Morrow MR and Schuler MS (2023).
Nurs Sci Q.
PubMed:
37309146

Blueberry, cranberry, raspberry, and strawberry as modulators of the gut microbiota: target for treatment of gut dysbiosis in chronic kidney disease? From current evidence to future possibilities.

Coutinho-Wolino KS et al (2024).
Nutr Rev.
PubMed:
37164634

Cranberry fruit epicuticular wax benefits and identification of a wax-associated molecular marker.

Erndwein L et al (2023).
BMC Plant Biol.
PubMed:
37020185

Aquitalea palustris sp. nov., isolated from a wild cranberry bog in the Cape Cod National Seashore.

Schreiber M, Harrison A and Soby S (2023).
Int J Syst Evol Microbiol.
PubMed:
37010949

Adherence of Uropathogenic Escherichia Coli in Dog Urine After Consumption of Food Supplemented with Cranberry (Vaccinium Macrocarpon).

Carvajal-Campos A et al (2023).
J Vet Res.
PubMed:
37008767

Formulation and Biopharmaceutical Evaluation of Capsules Containing Freeze-Dried Cranberry Fruit Powder.

Šedbarė R, Janulis V and Ramanauskiene K (2023).
Plants (Basel).
PubMed:
36987086

A Review on Berry Seeds-A Special Emphasis on Their Chemical Content and Health-Promoting Properties.

Review
Sławińska N, Prochoń K and Olas B (2023).
Nutrients.
PubMed:
36986152

Phytochemical Composition of the Fruit of Large Cranberry (Vaccinium macrocarpon Aiton) Cultivars Grown in the Collection of the National Botanic Garden of Latvia.

Šedbarė R, Jakštāne G and Janulis V (2023).
Plants (Basel).
PubMed:
36840117

Botanical Ingredient Forensics: Detection of Attempts to Deceive Commonly Used Analytical Methods for Authenticating Herbal Dietary and Food Ingredients and Supplements.

Review
Gafner S et al (2023).
J Nat Prod.
PubMed:
36716213

Fruits and their phytochemicals in mitigating the ill effects of ionizing radiation: review on the existing scientific evidence and way forward.

Raghu SV et al (2023).
Food Funct.
PubMed:
36688345

Nuclear Genome Sequence and Gene Expression of an Intracellular Fungal Endophyte Stimulating the Growth of Cranberry Plants.

Thimmappa BC et al (2023).
J Fungi (Basel).
PubMed:
36675947

Changes in the Composition of Biologically Active Compounds during the Ripening Period in Fruit of Different Large Cranberry (Vaccinium macrocarpon Aiton) Cultivars Grown in the Lithuanian Collection.

Šedbarė R, Pašakinskienė I and Janulis V (2023).
Plants (Basel).
PubMed:
36616331

Lowering fasting blood glucose with non-dialyzable material of cranberry extract is dependent on host genetic background, sex and diet.

Amer-Sarsour F et al (2023).
Animal Model Exp Med.
PubMed:
36404387

Candida krusei is the major contaminant of ultrafiltration and reverse osmosis membranes used for cranberry juice production.

Fikri S et al (2023).
Food Microbiol.
PubMed:
36309445

Cranberry: Chemical Composition, Antioxidant Activity and Impact on Human Health: Overview.

Review
Nemzer BV et al (2022).
Molecules.
PubMed:
35268605

Anthocran® Phytosome®: Prevention of Recurring Urinary Infections and Symptoms after Catheterization.

Cotellese R et al (2023).
J Diet Suppl.
PubMed:
34632933

Cranberry (Vaccinium macrocarpon) Is a Marginal Host for Brown Marmorated Stink Bug.

Jaffe BD et al (2021).
J Econ Entomol.
PubMed:
33760914

Cranberry Polyphenols and Prevention against Urinary Tract Infections: Relevant Considerations.

González de Llano D, Moreno-Arribas MV and Bartolomé B (2020).
Molecules.
PubMed:
32752183

Vegetable butters and oils in skin wound healing: Scientific evidence for new opportunities in dermatology.

Poljšak N, Kreft S and Kočevar Glavač N (2020).
Phytother Res.
PubMed:
31657094

Cranberry.

Review
(2022).
PubMed:
30000897

Vaccinium macrocarpon: an interesting option for women with recurrent urinary tract infections and other health benefits.

Review
Pérez-López FR, Haya J and Chedraui P (2009).
J Obstet Gynaecol Res.
PubMed:
19751320