Valeriana officinalis

Common Names: garden heliotrope, garden valerian

Ethnobotanical Studies

Clinical Trials

Valeriana officinalis Root Extract Modulates Cortical Excitatory Circuits in Humans.

Mineo L et al (2017).
Neuropsychobiology.
DOI:
10.1159/000480053
PubMed:
29035887

Studies

Safety evaluation of aqueous extract from Valeriana officinalis L. roots: Genotoxicity, acute, subchronic and teratology toxicity.

Bao H et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118687
PubMed:
39128798

Evaluation of the Effects of Extracts Containing Valeriana officinalis and Piper methysticum on the Activities of Cytochrome P450 3A and P-Glycoprotein.

Nascimento ML et al (2024).
Planta Med.
DOI:
10.1055/a-2360-4808
PubMed:
39013429

The wildcat (Felis s. silvestris) in the Mediterranean forest: sighting through photo-trapping and non-invasive hair collection for genetic purposes.

Petisco JS, Sánchez-Carrasco P and Fernández-García JL (2024).
Vet Res Commun.
DOI:
10.1007/s11259-024-10402-3
PubMed:
38771445

Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial.

Summary

Study tested Valeriana officinalis and Passiflora incarnata for anxiety and discomfort during extraction of two molars. Results can help improve patient experience during dental procedures.

Neuroscience
Velasquez ACA et al (2024).
Oral Maxillofac Surg.
DOI:
10.1007/s10006-024-01259-6
PubMed:
38743126

Therapeutic potential of hypnotic herbal medicines: A comprehensive review.

Review
Ghasemzadeh Rahbardar M and Hosseinzadeh H (2024).
Phytother Res.
DOI:
10.1002/ptr.8201
PubMed:
38595123

Potential of Plant-Based Extracts to Alleviate Sorbitol-Induced Osmotic Stress in Cabbage Seedlings.

Pacyga K et al (2024).
Plants (Basel).
DOI:
10.3390/plants13060843
PubMed:
38592867

Corrigendum: Phytotherapy for attention deficit hyperactivity disorder (ADHD): a systematic review and meta-analysis.

Summary

Researchers investigated the effects of a new compound on cancer cells. Results show potential for novel treatment options. Relevant for developing therapies in cancer research.

Neuroscience
Dutta T et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1365806
PubMed:
38549676

Optimizing the extract yield of bioactive compounds in Valeriana officinalis root: a D-optimal design.

Mokhtari A et al (2024).
Prep Biochem Biotechnol.
DOI:
10.1080/10826068.2023.2297709
PubMed:
38432680

Valerenic acid attenuates pathological myocardial hypertrophy by promoting the utilization of multiple substrates in the mitochondrial energy metabolism.

Summary

Researchers studied valerenic acid (VA) in Valeriana officinalis L. for its potential in treating pathological myocardial hypertrophy (PMH) with positive results. VA's regulatory effect on the cardiovascular system could provide new treatment options for cardiac diseases.

Cardiology
Liu T et al (2024).
J Adv Res.
DOI:
10.1016/j.jare.2024.02.008
PubMed:
38373650

New Iridoids and Acyclic Monoterpenoids from the Roots and Rhizomes of Valeriana officinalis var. latifolia.

Liu JJ et al (2024).
Chem Biodivers.
DOI:
10.1002/cbdv.202301949
PubMed:
38326086

Chemical Diversity of Wild-Growing and Cultivated Common Valerian (Valeriana officinalis L. s.l.) Originating from Poland.

Raj K et al (2023).
Molecules.
DOI:
10.3390/molecules29010112
PubMed:
38202695

Antidepressant effects of a Persian herbal formula on mice with chronic unpredictable mild stress.

Summary

A survey assessed the effects of a Persian herbal formula on mice with chronic stress. Herbal medicine may offer an alternative therapy for depression, addressing limitations in current medication options.

Neuroscience
Gavzan H et al (2023).
Avicenna J Phytomed.
DOI:
10.22038/AJP.2023.22191
PubMed:
38089415

Engineering Yarrowia lipolytica for the biosynthesis of geraniol.

Agrawal A, Yang Z and Blenner M (2023).
Metab Eng Commun.
DOI:
10.1016/j.mec.2023.e00228
PubMed:
38029016

Pharmaceutical agents as potential drivers in the development of Early-Onset Colorectal Cancer: A Case-Control Study.

Summary

The incidence of early-onset colorectal cancer (EOCRC) is increasing, not linked to known risk factors. Researchers hypothesize that a pharmaceutical agent may be the cause, suggesting the need for strategies to minimize this risk.

CancerGastroenterology
Ben-Aharon I et al (2023).
JMIR Public Health Surveill.
DOI:
10.2196/50110
PubMed:
37933755

CARDIOPROTECTIVE EFFECT OF DICHLOROMETHANE VALERIAN (VALERIANA OFFICINALIS) EXTRACT ON ISCHEMIA-REPERFUSION-INDUCED CARDIAC INJURIES IN RATS.

Summary

Valepotriate in valerian has potent antioxidant properties and is beneficial for various cardiovascular conditions.

Cardiology
Sedighi M et al (2023).
Acta Endocrinol (Buchar).
DOI:
10.4183/aeb.2023.178
PubMed:
37908890

Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study.

Chandra Shekhar H, Joshua L and Thomas JV (2023).
Adv Ther.
DOI:
10.1007/s12325-023-02708-6
PubMed:
37899385

Valerenic acid reduces anxiety-like behavior in young adult, female (C57BL/6J) mice.

Summary

Valeriana officinalis extract contains valerenic acid (VA) and is believed to treat anxiety and insomnia. In this study, VA was shown to have similar anxiety-reducing effects as diazepam without affecting locomotor activity or inducing depression-like behavior. VA could potentially be used as an anxiolytic drug.

Neuroscience
Pinder NE et al (2023).
Behav Brain Res.
DOI:
10.1016/j.bbr.2023.114717
PubMed:
37852540

Transient Complete Atrioventricular Block Associated With Herbal Supplement Use.

Kucuk U et al (2023).
S D Med.
PubMed:
37733962

Effect of Plant Extracts Combinations on TNF-α, IL-6 and IL-10 Levels in Serum of Rats Exposed to Acute and Chronic Stress.

Summary

This study examines the effects of combined plant extracts rich in flavonoids on cytokine levels in stressed rats. The extracts, Antistress I and Antistress II, showed potential in reducing pro-inflammatory cytokines (TNF-α and IL-6) and increasing anti-inflammatory cytokine (IL-10) levels. The combinations were more effective than individual extracts.

Immunology
Kandilarov I et al (2023).
Plants (Basel).
DOI:
10.3390/plants12173049
PubMed:
37687297

Herbal medicines in the treatment of children and adolescents with attention-deficit/hyperactivity disorder (ADHD): An updated systematic review of clinical trials.

Summary

This study reviewed herbal medicines and phytochemicals for treating ADHD in children. It offers an updated analysis to aid in making informed decisions for pediatric ADHD treatment.

Review Neuroscience
Golsorkhi H et al (2023).
Avicenna J Phytomed.
DOI:
10.22038/AJP.2022.21115
PubMed:
37663386

Tag and Snag: A New Platform for Bioactive Natural Product Screening from Mixtures.

Seidel J et al (2023).
Molecules.
DOI:
10.3390/molecules28155726
PubMed:
37570695

Influence of environmental conditions on the production of nutraceuticals in Italian edible plant landraces.

De Rossi S et al (2023).
Food Res Int.
DOI:
10.1016/j.foodres.2023.112483
PubMed:
36869496

Bioactive Compounds of Underground Valerian Extracts and Their Effect on Inhibiting Metabolic Syndrome-Related Enzymes Activities.

Wu CR et al (2023).
Foods.
DOI:
10.3390/foods12030636
PubMed:
36766164

Chitosan based encapsulation of Valeriana officinalis essential oil as edible coating for inhibition of fungi and aflatoxin B(1) contamination, nutritional quality improvement, and shelf life extension of Citrus sinensis fruits.

Phytochemistry
Das S et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.123565
PubMed:
36740131

Phytotherapy of mood disorders in the light of microbiota-gut-brain axis.

Summary

Research has revealed potential herbal medicines for treating mild mood disorders, but with unclear active components. The microbiota-gut-brain axis offers new avenues for treatment and prevention of mood disorders.

Review GastroenterologyNeuroscience
Korczak M et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154642
PubMed:
36641978

Valerenic Acid Promotes Adipocyte Differentiation, Adiponectin Production, and Glucose Uptake via Its PPARγ Ligand Activity.

Takahashi J et al (2022).
ACS Omega.
DOI:
10.1021/acsomega.2c06120
PubMed:
36591200

Intraspecific Variability of Wild-Growing Common Valerian (Valeriana officinalis L.).

Bączek KB et al (2022).
Plants (Basel).
DOI:
10.3390/plants11243455
PubMed:
36559567

Modulation of the metabolite content of the unicellular rhodophyte Porphyridium purpureum using a 2-stage cultivation approach and chemical stressors.

Barone ME et al (2022).
J Biotechnol.
DOI:
10.1016/j.jbiotec.2022.11.006
PubMed:
36375623

Neuroprotective Effects of Natural Antioxidants Against Branched-Chain Fatty Acid-Induced Oxidative Stress in Cerebral Cortex and Cerebellum Regions of the Rat Brain.

Summary

Valproic acid (VPA) is a neurotoxic fatty acid that may cause oxidative stress. In a study using rat brains, researchers tested the protective effects of antioxidants (melatonin, quercetin, and piperine) on VPA-induced stress. Results showed that these antioxidants were effective in preventing VPA-induced oxidative stress and mitigated the effects of VPA on certain brain activities. This suggests that a diet high in these antioxidants could be beneficial in combatting the negative effects of VPA.

Neuroscience
Chaudhary S, Pinky and Parvez S (2022).
ACS Omega.
DOI:
10.1021/acsomega.2c00163
PubMed:
36340064

The Appeal of Ethnobotanical Folklore Records: Medicinal Plant Use in Setomaa, Räpina and Vastseliina Parishes, Estonia (1888-1996).

Ethnobotany
Sõukand R and Kalle R (2022).
Plants (Basel).
DOI:
10.3390/plants11202698
PubMed:
36297723

Profile of Selected Secondary Metabolites and Antioxidant Activity of Valerian and Lovage Grown in Organic and Low-Input Conventional System.

Średnicka-Tober D et al (2022).
Metabolites.
DOI:
10.3390/metabo12090835
PubMed:
36144239

Identification of Nrf2 Activators from the Roots of Valeriana officinalis.

Afzal S et al (2023).
Planta Med.
DOI:
10.1055/a-1887-2016
PubMed:
35764305

Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.

Meta-Analysis
Shinjyo N, Waddell G and Green J (2020).
J Evid Based Integr Med.
DOI:
10.1177/2515690X20967323
PubMed:
33086877

Valerian.

Review
(2021).
PubMed:
30000874

Botanicals and Their Bioactive Phytochemicals for Women's Health.

Review Phytochemistry
Dietz BM et al (2016).
Pharmacol Rev.
PubMed:
27677719

Adverse effects of herbal medicines: an overview of systematic reviews.

Review
Posadzki P, Watson LK and Ernst E (2013).
Clin Med (Lond).
PubMed:
23472485

Valerian for sleep: a systematic review and meta-analysis.

Meta-Analysis
Bent S et al (2006).
Am J Med.
PubMed:
17145239

Valerian: Valeriana officinalis.

Review
Plushner SL et al (2000).
Am J Health Syst Pharm.
PubMed:
10714969