Vernonia amygdalina

Ethnobotanical Studies

Studies

In silico and in vivo evaluations of multistage antiplasmodial potency and toxicity profiling of n-Hexadecanoic acid derived from Vernonia amygdalina.

Afolayan FID, Odeyemi RA and Salaam RA (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1445905
PubMed:
39234111

Vernonia amygdalina Leaf Extract Induces Apoptosis in HeLa Cells: A Metabolomics and Proteomics Study.

Samutrtai P et al (2024).
Pharmaceuticals (Basel).
DOI:
10.3390/ph17081079
PubMed:
39204184

The Anticoccidial In Vitro Effects and Antioxidant Properties of Several Plants Traditionally Used for Coccidiosis in Togo.

Immunology
Tchodo FG et al (2024).
Vet Sci.
DOI:
10.3390/vetsci11080345
PubMed:
39195799

Effects of solvent extraction on the phytoconstituents and in vitro antioxidant activity properties of leaf extracts of the two selected medicinal plants from Malawi.

Immunology
Chatepa LEC et al (2024).
BMC Complement Med Ther.
DOI:
10.1186/s12906-024-04619-7
PubMed:
39192223

Consumption and adverse reaction reporting of herbal medicines among people living with HIV at University teaching hospitals in Blantyre, Malawi and Ibadan, Nigeria.

Mponda JS et al (2024).
Malawi Med J.
DOI:
10.4314/mmj.v36i1.3
PubMed:
39086363

Effect of single and combination therapy on methanol extracts of Khaya senegalensis stem bark, Vernonia amygdalina leaves and Garcinia kola seed in Leptospira interrogans-infected mice.

Abiayi EA et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118601
PubMed:
39059686

Indigenous herbal medicine use and its associated factors among pregnant women attending antenatal care at public health facilities in Dire Dawa, Ethiopia: a cross-sectional study.

Mohammed A et al (2024).
BMJ Open.
DOI:
10.1136/bmjopen-2023-079719
PubMed:
38830740

Use of Botanical Ingredients: Nice Opportunities to Avoid Premature Oxidation of NABLABs by Increasing Their ORAC Values Strongly Impacted by Dealcoholization or Pasteurization.

Simon M, Kageruka H and Collin S (2024).
Molecules.
DOI:
10.3390/molecules29102370
PubMed:
38792230

Highly efficient catalytic degradation of organic dyes using iron nanoparticles synthesized with Vernonia Amygdalina leaf extract.

Jara YS, Mekiso TT and Washe AP (2024).
Sci Rep.
DOI:
10.1038/s41598-024-57554-5
PubMed:
38523139

Comparative analysis of the physicochemical, proximate, and antioxidant characteristics of stingless bee (Meliponula beccarii) honey from modern and wild beehives in Ethiopia.

ImmunologyPhytochemistry
Negera T, Degu A and Tigu F (2023).
Food Sci Nutr.
DOI:
10.1002/fsn3.3861
PubMed:
38455209

Immune boosting and ameliorative properties of aqueous extract of Vernonia amygdalina Delile against MSG-induced genotoxicity: An in silico and in vivo approach.

Abiola T et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e23226
PubMed:
38163244

The ethyl acetate extract of Vernonia amygdalina leaf ameliorates gemcitabine effect against migration and invasion of PANC-1 cells via down-regulation the VEGF, COX(2), and RAS/MEK pathways.

Hasibuan PAZ et al (2024).
Saudi Pharm J.
DOI:
10.1016/j.jsps.2023.101872
PubMed:
38111670

Therapeutic Benefit of Vernonia amygdalina in the Treatment of Diabetes and Its Associated Complications in Preclinical Studies.

Summary

This summary examines the potential of Vernonia amygdalina (VA) in treating diabetes mellitus (DM) and complications. VA shows strong antidiabetic properties due to its phytochemicals, providing future research prospects. As a scientist, this research offers insights into a herbal treatment for DM.

Review Diabetes
Asante DB and Wiafe GA (2023).
J Diabetes Res.
DOI:
10.1155/2023/3159352
PubMed:
38033739

The Antidiabetic Activity of Combining the Aqueous Extracts of Vernonia amygdalina Leaves and Tamarindus indica Fruit Pulp in Streptozotocin-Induced Wistar Rats.

Summary

Researchers investigated the antioxidant and antidiabetic activities of a combination of and extracts. The combination showed significant reduction in diabetes-related markers and could be beneficial for diabetic patients.

Diabetes
Tekou FA et al (2023).
Cureus.
DOI:
10.7759/cureus.46807
PubMed:
37954696

Inhibitory Effects of Vernonia amygdalina Leaf Extracts on Free Radical Scavenging, Tyrosinase, and Amylase Activities.

Patathananone S et al (2023).
Prev Nutr Food Sci.
DOI:
10.3746/pnf.2023.28.3.302
PubMed:
37842258

Blood pressure lowering effects of Vernonia amygdalina Del. Aqueous fraction on hypertensive Wistar Kyoto rats.

Summary

Researchers investigated the blood pressure-lowering effect of Vernonia amygdalina leaf's aqueous fraction (VALAF) in a hypertensive model. VALAF contains secondary metabolites with antioxidant, anticancer, antidiabetic, and hepatoprotective properties.

Cardiology
Juwita DA et al (2023).
J Complement Integr Med.
DOI:
10.1515/jcim-2022-0416
PubMed:
37831720

Serum inflammation and oxidative DNA damage amelioration in cocks-fed supplemental Vernonia amygdalina and zinc in aflatoxin B(1) contaminated diets.

GeneticsImmunology
Olarotimi OJ et al (2023).
Transl Anim Sci.
DOI:
10.1093/tas/txad113
PubMed:
37786424

Ethnomedicinal plants used for malaria treatment in Rukungiri District, Western Uganda.

Summary

They studied the use of medicinal plants for treating malaria in a region of Uganda where medical facilities are limited. Understanding local knowledge can help improve malaria management in the area.

Ethnobotany
Gumisiriza H et al (2023).
Trop Med Health.
DOI:
10.1186/s41182-023-00541-9
PubMed:
37644587

Green synthesis of silver nanoparticles using Vernonia amygdalina plant extract and its antimicrobial activities.

Summary

Researchers used leaf extract as a green and sustainable method to synthesize silver nanoparticles. The nanoparticles showed antimicrobial properties against both Gram-positive and Gram-negative bacteria.

Antimicrobial
Tesfaye M et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e17356
PubMed:
37383214

Medicinal plants used for treatment of malaria by indigenous communities of Tororo District, Eastern Uganda.

Tabuti JRS et al (2023).
Trop Med Health.
DOI:
10.1186/s41182-023-00526-8
PubMed:
37303066

Vernonia amygdalina Ethanol Extract Protects against Doxorubicin-Induced Cardiotoxicity via TGFβ, Cytochrome c, and Apoptosis.

Syahputra RA et al (2023).
Molecules.
DOI:
10.3390/molecules28114305
PubMed:
37298779

[Properties of new exotic traditional Chinese medicinal Vernonia amygdalina leaves:a literature research].

Review
Wang ZH et al (2023).
Zhongguo Zhong Yao Za Zhi.
DOI:
10.19540/j.cnki.cjcmm.20221116.401
PubMed:
37282915

In vivo anticoccidial activity and immune response of Moringa oleifera and Vernonia amygdalina leaves against Eimeria magna and Eimeria media in rabbits.

Konmy B et al (2023).
Front Cell Infect Microbiol.
DOI:
10.3389/fcimb.2023.1173138
PubMed:
37274317

Effect of Bitter-leaf (Vernonia amygdalina) Flavored Non-alcoholic Wheat Beer (NAWB) on, Insulin and GLUT-2 expression in Pancreas of High fat diet/Streptozotocin (HFD/STZ) Induced Diabetic Wistar Rats.

Summary

This study explored the impact of bitter leaf-flavored non-alcoholic wheat beer on insulin secretion and GLUT-2 expression in diabetic rats, potentially relevant for managing type 2 diabetes.

Diabetes
Akerele GP et al (2023).
J Diabetes Metab Disord.
DOI:
10.1007/s40200-023-01216-2
PubMed:
37255795

Luteolin and Vernodalol as Bioactive Compounds of Leaf and Root Vernonia amygdalina Extracts: Effects on α-Glucosidase, Glycation, ROS, Cell Viability, and In Silico ADMET Parameters.

Djeujo FM et al (2023).
Pharmaceutics.
DOI:
10.3390/pharmaceutics15051541
PubMed:
37242783

African leaf (Vernonia amygdalina) extracts improve Japanese quail (Coturnix coturnix japonica) carcass traits.

Kismiati S et al (2023).
Vet World.
DOI:
10.14202/vetworld.2023.773-778
PubMed:
37235162

Melissopalynological analysis and floral spectra of Apis mellifera scutellata Lepeletier bees in different agroecologies of southwest Ethiopia.

Tulu D et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e16047
PubMed:
37215831

In vitro antioxidant and free-radical scavenging activities of polar leaf extracts of Vernonia amygdalina.

Immunology
Hussen EM and Endalew SA (2023).
BMC Complement Med Ther.
DOI:
10.1186/s12906-023-03923-y
PubMed:
37143058

Isotonic, aqueous-based media as simple and suitable test media for short-term Haemonchus placei adult worm motility assay.

Aderibigbe SA, Idowu SO and Olaniyi AA (2023).
Exp Parasitol.
DOI:
10.1016/j.exppara.2023.108516
PubMed:
36967034

A review of efficacy and safety of Ugandan anti-malarial plants with application of RITAM score.

Review
Angupale JR, Tusiimire J and Ngwuluka NC (2023).
Malar J.
DOI:
10.1186/s12936-023-04486-6
PubMed:
36932389

Effect of Ethanolic Extract of Vernonia amygdalina on the Proliferation, Viability and Function of Mouse Induced Pluripotent Stem Cells and Cardiomyocytes.

Cardiology
Nguemfo Tchankugni A et al (2023).
Plants (Basel).
DOI:
10.3390/plants12051108
PubMed:
36903967

Synergistic Antibacterial Effect of Ethyl Acetate Fraction of Vernonia amygdalina Delile Leaves with Tetracycline against Clinical Isolate Methicillin-Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa.

Satria D et al (2023).
Adv Pharmacol Pharm Sci.
DOI:
10.1155/2023/2259534
PubMed:
36860376

Different proportions of dried Vernonia amygdalina leaves and wheat bran mixture supplementation on feed intake, digestibility and body weight change of Arsi-Bale sheep fed with natural pasture hay as basal diet.

Adugna W, Ayele S and Addis M (2023).
Vet Med Sci.
DOI:
10.1002/vms3.1068
PubMed:
36680563

Pollution impact assessment of secondary iron smelting on soil and some medicinal herbs grown at Fasina community in Ile-Ife, Nigeria.

Akinlade GO et al (2023).
Environ Monit Assess.
DOI:
10.1007/s10661-023-10922-6
PubMed:
36640219

Vernonia amygdalina Delile Induces Apoptotic Effects of PC3 Cells: Implication in the Prevention of Prostate Cancer.

Cancer
Yedjou CG et al (2022).
J Biomed Res Environ Sci.
DOI:
10.37871/jbres1564
PubMed:
36578651

Antimicrobial and Antibiotic-Resistance Reversal Activity of Some Medicinal Plants from Cameroon against Selected Resistant and Non-Resistant Uropathogenic Bacteria.

Antimicrobial
Arsene MMJ et al (2022).
Front Biosci (Elite Ed).
DOI:
10.31083/j.fbe1404025
PubMed:
36575849

Can Crude Oil Exploration Influence the Phytochemicals and Bioactivity of Medicinal Plants? A Case of Nigerian Vernonia amygdalina and Ocimum gratissimum.

Phytochemistry
Diyaolu OA et al (2022).
Molecules.
DOI:
10.3390/molecules27238372
PubMed:
36500460

Health-promoting foods and food crops of West-Africa origin: The bioactive compounds and immunomodulating potential.

Review
Elegbeleye JA et al (2022).
J Food Biochem.
DOI:
10.1111/jfbc.14331
PubMed:
36448596

Rapid identification of stigmastane-type steroid saponins from Vernonia amygdalina leaf based on α-glucosidase inhibiting activity and molecular networking.

Phytochemistry
Gao J et al (2022).
Chin J Nat Med.
DOI:
10.1016/S1875-5364(22)60235-8
PubMed:
36427918

Glycemic indices and effect of bitter leaf (Vernonia amygdalina) flavored non-alcoholic wheat beer (NAWB) on key carbohydrate metabolizing enzymes in high fat diet fed (HFD)/STZ-induced diabetic Wistar rats.

Diabetes
Akerele GP et al (2022).
J Food Biochem.
DOI:
10.1111/jfbc.14511
PubMed:
36370433

Zingiber officinale and Vernonia amygdalina Infusions Improve Redox Status in Rat Brain.

Summary

This study explored how tea infusions affect the brain health of rats. Twenty-four rats were divided into four groups, with one serving as a control. The test groups received either root, leaf, or a combination of both infusions orally for one week. Results showed that the infusions decreased levels of harmful compounds in the rats' brain tissue and increased levels of beneficial ones. The study demonstrates the positive antioxidant properties of the infusions, which could have health benefits for humans.

Neuroscience
Rotimi DE et al (2022).
Evid Based Complement Alternat Med.
DOI:
10.1155/2022/9470178
PubMed:
36199544

Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity.

Summary

Researchers investigated the medicinal plant Del. and found eight new steroids. Through various methods, they determined the structure and activity of these compounds in reducing neuroinflammation. One compound, in particular, showed promise in reducing inflammation by blocking certain cellular pathways. This study highlights the potential therapeutic benefits of natural compounds in treating neurological disorders.

ImmunologyNeuroscience
Liu X et al (2022).
Pharmaceuticals (Basel).
DOI:
10.3390/ph15091160
PubMed:
36145381

Identification of promising multi-targeting inhibitors of obesity from Vernonia amygdalina through computational analysis.

Obesity
Ogunyemi OM et al (2023).
Mol Divers.
DOI:
10.1007/s11030-022-10397-6
PubMed:
35179699

Vernonia amygdalina stimulates muscle glucose uptake and modulates redox activities and functional chemistry in oxidative hepatic injury.

Erukainure OL and Islam MS (2022).
J Food Biochem.
DOI:
10.1111/jfbc.13794
PubMed:
34057221

Effect of aqueous extract of Vernonia amygdalina on atherosclerosis in rabbits.

Abdulmalik O, Oladapo OO and Bolaji MO (2016).
ARYA Atheroscler.
PubMed:
27114735