Viola odorata

Common Names: sweet violet

Ethnobotanical Studies

Clinical Trials

Efficacy and safety of add-on Viola odorata L. in the treatment of COVID-19: A randomized double-blind controlled trial.

Sweet violet syrup, used in traditional Persian medicine, may help treat COVID-19 symptoms by enhancing respiratory functions and reducing inflammation, according to a study. Confirmation from additional research is required. (40 characters)

Adel Mehraban MS et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.116058
PubMed:
36535329

Studies

Down-regulation of NF-κB signalling by methanolic extract of Viola odorata (L.) attenuated in vivo inflammatory and angiogenic responses.

Immunology
Andleeb F et al (2024).
Inflammopharmacology.
DOI:
10.1007/s10787-024-01505-z
PubMed:
39030451

Discovery and development of macrocyclic peptide modulators of the cannabinoid 2 receptor.

Tomašević N et al (2024).
J Biol Chem.
DOI:
10.1016/j.jbc.2024.107330
PubMed:
38679329

Effects of Viola odorata syrup on sleep quality in menopausal women: a randomized, triple-blind, controlled trial.

Karimi FZ et al (2024).
Sleep Breath.
DOI:
10.1007/s11325-023-02979-x
PubMed:
38177831

Antidepressant effects of a Persian herbal formula on mice with chronic unpredictable mild stress.

Summary

A survey assessed the effects of a Persian herbal formula on mice with chronic stress. Herbal medicine may offer an alternative therapy for depression, addressing limitations in current medication options.

Neuroscience
Gavzan H et al (2023).
Avicenna J Phytomed.
DOI:
10.22038/AJP.2023.22191
PubMed:
38089415

Detection of Coumarin Derivatives of Viola odorata Cultivated in Iraq.

Ali ZA, Saleh I and Alani WM (2023).
J Pharm Bioallied Sci.
DOI:
10.4103/jpbs.jpbs_270_23
PubMed:
37694059

Intelligent double-layer polymers based on carboxymethyl cellulose-cellulose nanocrystals film and poly(lactic acid)-Viola odorata petal anthocyanins nanofibers to monitor food freshness.

Rezaei F, Tajik H and Shahbazi Y (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.126512
PubMed:
37633548

Development and Characterization of Antioxidant and Antibacterial Films Based on Potato Starch Incorporating Viola odorata Extract to Improve the Oxidative and Microbiological Quality of Chicken Fillets during Refrigerated Storage.

Summary

Active films made from potato starch containing extract (VOE) showed increased antioxidant and antibacterial activity in vitro and in chicken fillets. These films can extend the shelf life of chicken fillets during cold storage for at least eight days.

Immunology
Nikmanesh A, Baghaei H and Mohammadi Nafchi A (2023).
Foods.
DOI:
10.3390/foods12152955
PubMed:
37569224

Antibacterial Activity of Economically Important Medicinal Plants in Pakistan Against Different Bacterial Strains.

Ali A et al (2023).
Bioinform Biol Insights.
DOI:
10.1177/11779322231189374
PubMed:
37533430

Efficacy and Safety of Add-On Plant-Based Drugs for COVID-19 Patients: A Review of the Randomized Control Trials.

Summary

Review finds that plant-based drugs, particularly herbs, used as add-on therapy for COVID-19 show efficacy and safety, potentially enhancing the immune system for treating the virus. (37 words)

Review COVID-19
Diantini A, Febriyanti RM and Levita J (2023).
Infect Drug Resist.
DOI:
10.2147/IDR.S417727
PubMed:
37361940

The Efficacy of an Oral Formulation of Glycyrrhiza glabra, Viola odorata, and Operculina turpethum as an Add-on Therapy for Mild-to-moderate Childhood Asthma: A Randomized Placebo-Controlled Clinical Trial.

Summary

This study tested a new oral tablet for children with mild-to-moderate asthma. It assessed how well it reduced symptoms and could potentially be used as an additional treatment.

Asthma
Rabbani F et al (2023).
J Res Pharm Pract.
DOI:
10.4103/jrpp.jrpp_77_22
PubMed:
37304220

Attenuating NF-κB/VCAM-1 Expression in the Middle Cerebral Artery Occlusion Model by Viola Odorata: Protection Against Ischemia-Reperfusion Injury in Rats.

Cardiology
Karimifar K et al (2022).
Basic Clin Neurosci.
DOI:
10.32598/bcn.12.6.2061.1
PubMed:
36457883

Cyclic cystine knot and its strong implication on the structure and dynamics of cyclotides.

Venkatesan J and Roy D (2023).
Proteins.
DOI:
10.1002/prot.26426
PubMed:
36107799

Morphological studies of self-assembled cyclotides extracted from Viola odorata as novel versatile platforms in biomedical applications.

Dayani L et al (2022).
Biomater Sci.
DOI:
10.1039/d2bm00848c
PubMed:
35833353

The Efficacy of V. odorata Extract in the Treatment of Insomnia: A Systematic Review and Meta-Analysis.

Huang S et al (2022).
Front Neurol.
DOI:
10.3389/fneur.2022.730311
PubMed:
35734476

Immunomodulatory effects of cyclotides isolated from Viola odorata in an experimental autoimmune encephalomyelitis animal model of multiple sclerosis.

Summary

Researchers investigated the effect of cyclotide-rich fractions from Viola odorata, a type of plant protein, on an animal model of MS. MS is a chronic inflammation disease that damages the central nervous system. The study aimed to identify whether cyclotides had immunomodulatory properties that could help treat MS.

ImmunologyNeuroscience
Dayani L et al (2022).
Mult Scler Relat Disord.
DOI:
10.1016/j.msard.2022.103958
PubMed:
35716476

Impact of Drying Conditions on Antioxidant Activity of Red Clover (Trifolium pratense), Sweet Violet (Viola odorata) and Elderberry Flowers (Sambucus nigra).

Zawiślak A et al (2022).
Materials (Basel).
DOI:
10.3390/ma15093317
PubMed:
35591648

The involvement of cyclotides in mutual interactions of violets and the two-spotted spider mite.

Slazak B et al (2022).
Sci Rep.
DOI:
10.1038/s41598-022-05461-y
PubMed:
35115562

Role of Herbal Medicines in the Management of Brain Injury.

Summary

This review evaluated studies on the role of herbal medicines in managing brain injury. Researchers searched various databases and found 32 studies with medicinal plants like Ginkgo biloba and olive that showed significant improvements in brain injury. The plants worked through different mechanisms, such as reducing free radicals and nitric oxide toxicity and increasing neuronal density. The review summarized the neuroprotective actions and molecular mechanisms of each plant. Overall, herbal medicines show promise in preventing and managing brain injury.

Review Neuroscience
Safdari MR et al (2021).
Adv Exp Med Biol.
DOI:
10.1007/978-3-030-73234-9_19
PubMed:
34981485

Pharmacological Screening of Viola odorata L. for Memory-Enhancing Effect via Modulation of Oxidative Stress and Inflammatory Biomarkers.

Immunology
Saleem U et al (2021).
Front Pharmacol.
DOI:
10.3389/fphar.2021.664832
PubMed:
34149418

Suppressive role of Viola odorata extract on malignant characters of mammosphere-derived breast cancer stem cells.

Cancer
Yousefnia S et al (2020).
Clin Transl Oncol.
DOI:
10.1007/s12094-020-02307-9
PubMed:
32056127

The mechanism of neuroprotective effect of Viola odorata against serum/glucose deprivation-induced PC12 cell death.

Summary

This study aimed to investigate the antioxidant potential of L in protecting brain cells from damage due to reduced oxygen supply and glucose. Researchers tested the methanol extract and other isolated fractions of L in PC12 cells subjected to serum and glucose deprivation. The results showed that the extract and fractions had significant neuro-protective effects and could scavenge reactive oxygen species. Overall, this study suggests that L may have a potential role in the management of oxidative stress-related neurodegenerative disorders.

Neuroscience
Tayarani-Najaran Z et al (2019).
Avicenna J Phytomed.
DOI:
10.22038/AJP.2019.13098
PubMed:
31763208

Fungal endophytes associated with Viola odorata Linn. as bioresource for pancreatic lipase inhibitors.

Katoch M et al (2017).
BMC Complement Altern Med.
DOI:
10.1186/s12906-017-1893-y
PubMed:
28774309

Anti-melanogenic activity of Viola odorata different extracts on B16F10 murine melanoma cells.

Rahimi VB et al (2017).
Iran J Basic Med Sci.
DOI:
10.22038/ijbms.2017.8350
PubMed:
28392894

Efficacy of Viola odorata in Treatment of Chronic Insomnia.

Feyzabadi Z et al (2014).
Iran Red Crescent Med J.
DOI:
10.5812/ircmj.17511
PubMed:
25763239