Viscum album

Common Names: European mistletoe

Ethnobotanical Studies

Studies

Mistletoe-induced carbon, water and nutrient imbalances are imprinted on tree rings.

de Andrés EG et al (2024).
Tree Physiol.
PubMed:
39163491

Component Composition and Features of Biological Activity of Viscum album (Viscaceae).

Adzhiakhmetova SL et al (2024).
Dokl Biol Sci.
PubMed:
39128961

Modulation of Breast Cancer Cell Apoptosis and Macrophage Polarization by Mistletoe Lectin in 2D and 3D Models.

Summary

Korean mistletoe lectin (VCA) enhances breast cancer cell apoptosis by influencing M1 and M2 macrophage polarization. Results suggest potential for VCA as an anti-cancer agent.

Hong CE and Lyu SY (2024).
Int J Mol Sci.
PubMed:
39126027

Pre-treatment of Cucurbita maxima 'Hokkaido orange' by Viscum album aqueous extracts in search of allelopathic potential.

Strashok O et al (2024).
Sci Rep.
PubMed:
38942921

Self-Nanoemulsifying Drug Delivery System (SNEDDS) Using Lipophilic Extract of Viscum album subsp. austriacum (Wiesb.) Vollm.

Pereira CFA et al (2024).
Int J Nanomedicine.
PubMed:
38895147

Chronobiology of Viscum album L.: a time series of daily metabolomic fingerprints spanning 27 years.

Guglielmetti G et al (2024).
Front Physiol.
PubMed:
38860114

Vortex-like vs. turbulent mixing of a Viscum album preparation affects crystalline structures formed in dried droplets.

Kokornaczyk MO et al (2024).
Sci Rep.
PubMed:
38839929

Patients with Advanced or Metastasised Non-Small-Cell Lung Cancer with Viscum album L. Therapy in Addition to PD-1/PD-L1 Blockade: A Real-World Data Study.

Summary

Adding VA to PD-1/PD-L1 inhibitors in NSCLC patients improves overall survival. 56% reduced risk of death compared to PD-1/PD-L1 alone, especially in PD-L1-positive tumors. Need more trials for confirmation.

Schad F et al (2024).
Cancers (Basel).
PubMed:
38672690

Acaricidal Efficacy of Thirty-Five Egyptian Plants Against the Camel Tick, Hyalomma Dromedarii.

Khater HF et al (2024).
Acta Parasitol.
PubMed:
38671280

The cardioprotective potential of selected species of mistletoe.

Summary

Mistletoe, especially L., may have cardioprotective properties for treating CVD. Further research is needed to understand its mechanisms, interactions with drugs, and determine therapeutic doses for clinical use.

Review Cardiology
Olas B et al (2024).
Front Pharmacol.
PubMed:
38666019

Comparison of epoprostenol and viscum album efficiencies in the treatment of avascular necrosis of the femoral head: An experimental animal study.

Kumbaraci M et al (2024).
Histol Histopathol.
PubMed:
38661187

Potentials of Phyllanthus amarus, Viscum album and Moringa oleifera supplements to mitigate heat stress in female rabbits in humid tropics.

Jimoh OA et al (2024).
J Anim Sci Technol.
PubMed:
38618034

Pharmakokinetics of Mistletoe Lectins after Intravenous Application of a Mistletoe Product in Healthy Subjects.

Lederer AK et al (2024).
Pharmaceuticals (Basel).
PubMed:
38543063

A randomized placebo-controlled double-blinded study comparing oral and subcutaneous administration of mistletoe extract for the treatment of equine sarcoid disease.

Beermann A et al (2024).
J Vet Intern Med.
PubMed:
38529853

Viscum album Lipophilic Extract in Actinic Keratosis, Cutaneous Squamous Cell Carcinoma and Basal Cell Carcinoma: A Retrospective Case Series.

Königsberger K et al (2024).
Complement Med Res.
PubMed:
38447556

Viscum album (mistletoe) extract for dogs with cancer?

Summary

This paper suggests using mistletoe extract as a potential treatment for dogs with cancer. It contains compounds that can inhibit cancer cell growth and stimulate the immune system, improving well-being. Its low side effect profile makes it worth considering.

Review Cancer
Klingemann H et al (2024).
Front Vet Sci.
PubMed:
38234984

Viscum album, as alternative and bridge to palliative chemotherapy in recurrent gallbladder cancer following laparoscopic radical cholecystectomy: a case report.

Summary

A 78-year-old woman with gallbladder cancer refused further chemotherapy after recurrence. She started Viscum album therapy, which decreased metastases and reduced CA19-9 levels. This therapy could be a bridge to palliative chemotherapy for patients unable to undergo standard treatment for recurrent gallbladder cancer.

Shin J, Yim E and Kang CM (2023).
Korean J Clin Oncol.
PubMed:
38229495

Integrative Oncology Approaches to Supporting Immune Checkpoint Inhibitor Treatment of Solid Tumours.

Summary

This review explores how integrative oncology strategies can support immune checkpoint inhibitor treatment for adult solid tumors. It is important because it can inform decisions on integrating these strategies to enhance the effectiveness of ICI treatment.

Review Cancer
Fuller-Shavel N and Krell J (2024).
Curr Oncol Rep.
PubMed:
38194216

Clinical characteristics and therapeutic behavior of breast cancer patients using mistletoe therapy consulting a clinic offering integrative oncology: a registry data analysis.

Summary

Study investigated treatment patterns of breast cancer patients in Switzerland using complementary and alternative medicine. Understanding this can improve integrative oncology care in the country.

Krüerke D, Schenker M and Matter-Walstra K (2023).
BMC Complement Med Ther.
PubMed:
37924102

The pollination ecology of a rare case of bee-pollinated Psittacanthus mistletoe.

Castro SJ et al (2023).
Plant Biol (Stuttg).
PubMed:
37850399

Mistletoe Extracts from Different Host Trees Disparately Inhibit Bladder Cancer Cell Growth and Proliferation.

Summary

Different mistletoe extracts from hawthorn, lime trees, willow trees, and poplar trees significantly inhibited bladder cancer cell growth. The extracts also induced apoptosis and altered the expression of certain proteins involved in cell cycle regulation. Integrating mistletoe into treatment regimens could optimize bladder cancer therapy.

Juengel E et al (2023).
Cancers (Basel).
PubMed:
37835543

Mistletoe Extracts during the Oncological Perioperative Period: A Systematic Review and Meta-Analysis of Human Randomized Controlled Trials.

Review
Cogo E et al (2023).
Curr Oncol.
PubMed:
37754510

Spatial aggregation patterns in four mistletoe species: ecological and environmental determinants.

Ojeda S et al (2023).
Plant Biol (Stuttg).
PubMed:
37703542

Which is the More Effective Option for Pleurodesis to Prevent the Recurrence of Malignant Pleural Effusion? Large-Particle Talc or Mistletoe Extract (ABNOVA Viscum Injection).

Han C et al (2023).
J Chest Surg.
PubMed:
37574878

Viscum album Induces Apoptosis by Regulating STAT3 Signaling Pathway in Breast Cancer Cells.

Summary

This study investigated the anticancer effects of a parasitic plant (VaM) on breast cancer cells. VaM inhibited cell growth, induced cell death, and suppressed cancer signaling pathways. Combining VaM with low-dose doxorubicin showed promising results in treating breast cancer.

Park YR et al (2023).
Int J Mol Sci.
PubMed:
37569363

Herbal inclusions ameliorate effect of heat stress on haematology, proinflammatory cytokines, adipokines and oxidative stress of weaned rabbit does in humid tropics.

Summary

This study found that including Moringa oleifera, Phyllanthus amarus, and Viscum album leaf meal in the diet of weaned female rabbits can reduce the negative effects of heat stress. These herbal inclusions improve antioxidant activity, lower lipid peroxidation, and suppress inflammation in rabbits.

Jimoh OA et al (2023).
J Anim Physiol Anim Nutr (Berl).
PubMed:
37526207

The Antioxidant Activity of Mistletoes (Viscum album and Other Species).

Summary

This review discusses the various species of mistletoe and their antioxidant effects. While the European mistletoe is widely used in medical treatments, the potential of other mistletoe species is still unclear.

Review Immunology
Nicoletti M et al (2023).
Plants (Basel).
PubMed:
37514321

Seasonal variations of triterpene acid contents in Viscum album L. on typical host trees of Hyrcanian forests.

Soursouri A, Hosseini SM and Fattahi F (2023).
Sci Rep.
PubMed:
37463985

Patient' and social aspects related to complementary mistletoe therapy in patients with breast cancer: A systematic review commissioned by the German agency for Health Technology Assessment.

Summary

In a health technology assessment, researchers examined the "Patient and Social aspects" of mistletoe therapy in breast cancer patients in German-speaking countries. Many patients choose this therapy alongside conventional treatment to reduce side effects and enhance their quality of life. By evaluating the value for users, the study aims to understand the significance of complementary mistletoe therapy in breast cancer care.

Steigenberger C et al (2023).
Eur J Oncol Nurs.
PubMed:
37321128

Green Synthesis of Zinc Oxide Nanoparticles Using Viscum album Extracts: Unveiling Bioactive Compounds, Antibacterial Potential, and Antioxidant Activities.

Mushtaq W et al (2023).
Plants (Basel).
PubMed:
37299109

Phytomediated-Assisted Preparation of Cerium Oxide Nanoparticles Using Plant Extracts and Assessment of Their Structural and Optical Properties.

Fifere N et al (2023).
Int J Mol Sci.
PubMed:
37240263

Herbal supplements suppress pro-inflammatory cytokines, boost humoral immunity, and modulate adipokines to enhance the productivity traits of rabbit bucks in hot climatic conditions.

Abubakar JO et al (2023).
Trop Anim Health Prod.
PubMed:
37227575

Water status and macronutrient concentrations, but not carbon status, of Viscum album ssp. album are determined by its hosts: a study across nine mistletoe-host pairs in central Switzerland.

Wang A et al (2023).
Front Plant Sci.
PubMed:
37223783

A Scoping Review of Genus Viscum: Biological and Chemical Aspects of Alcoholic Extracts.

Review
Melo MNO et al (2023).
Plants (Basel).
PubMed:
37176869

Facile one-step synthesis of gold nanoparticles using Viscum album and evaluation of their antibacterial potential.

Ishaq M et al (2023).
Funct Plant Biol.
PubMed:
37161500

Expression, purification, characterization, and cytotoxic evaluation of the ML1-STxB fusion protein.

Yousefi MH et al (2023).
Arch Microbiol.
PubMed:
37148384

Antitumor Effect of Iscador on Breast Cancer Cell Lines with Different Metastatic Potential.

Robev B et al (2023).
Int J Mol Sci.
PubMed:
36982323

Mistletoe (Viscum album L.) extract attenuates ıtraconazole-ınduced acute oxidative stress and hepatocellular ınjury in rats.

Çetin ES et al (2023).
Pak J Pharm Sci.
PubMed:
36967491

Investigations on the morpho-anatomy and histochemistry of the European mistletoe: Viscum album L. subsp. album.

de Almeida VP et al (2023).
Sci Rep.
PubMed:
36944660

Computational evaluation of bioactive compounds from Viscum album (mistletoe) as inhibitors of p63 for pancreatic cancer treatment.

Dairo G et al (2023).
J Biomol Struct Dyn.
PubMed:
36935102

Characterisation of Viscum album L. effect on immune escape proteins PD-L1, PD-L2 and MHC-I in prostate, colon, lung and breast cancer cells.

Kowarschik S et al (2023).
Complement Med Res.
PubMed:
36927644

Evaluation of quality of life in lung cancer patients receiving radiation and Viscum album L.: a real-world data study.

Schad F et al (2023).
Radiat Oncol.
PubMed:
36879290

Seroma prevention with topical Abnobaviscum sclerotherapy following excision of giant cervical lipoma.

Choi JH et al (2023).
Arch Craniofac Surg.
PubMed:
36858355

Safety of Combined Targeted and Helixor(®)Viscum album L. Therapy in Breast and Gynecological Cancer Patients, a Real-World Data Study.

Schad F and Thronicke A (2023).
Int J Environ Res Public Health.
PubMed:
36767928

Drug interactions causing warfarin overdose in a patient with a pancreatic cancer : a case report.

Moussouni M et al (2022).
Chemotherapy.
PubMed:
36446317

Viscum album prevents haematological changes, electrolyte imbalance, changes in liver function enzymes and histological alterations in some selected tissues in cadmium chloride-intoxicated rats.

Innih SO et al (2022).
Saudi J Biol Sci.
PubMed:
36389211

Viscum album mother tinctures: Harvest conditions and host trees influence the plant metabolome and the glycolytic pathway of breast cancer cells.

Melo MNO et al (2022).
Front Pharmacol.
PubMed:
36386174

The future of Viscum album L. in Europe will be shaped by temperature and host availability.

Walas Ł et al (2022).
Sci Rep.
PubMed:
36224233

Mistletoe.

Review
(2022).
PubMed:
35998245

In-Vitro Growth Kinetics of Mesenchymal Stem Cells in Cytotoxicity Tests Using Low-Diluted Viscum Album.

Valle ACV et al (2023).
Homeopathy.
PubMed:
35988582

The photosynthesis apparatus of European mistletoe (Viscum album).

Schröder L et al (2022).
Plant Physiol.
PubMed:
35976139

Phytochemical screening and effect of Viscum album L. on monoamine oxidase A and B activity and serotonin, dopamine and serotonin receptor 5-HTR1A levels in Galleria mellonealla (Lepidoptera).

Summary

European mistletoe has been traditionally used for central nervous system disorders, but little is known about its neuropharmacological activity. This study aims to investigate the effects of Viscum album L. on motor and anxiety-related behavior in mice. The study found that the extract of mistletoe had a significant calming effect on the mice, reducing anxiety and improving motor behaviors. This highlights the potential neuropharmacological activity of European mistletoe in treating CNS disorders.

Szurpnicka A et al (2022).
J Ethnopharmacol.
PubMed:
35944736

Viscum album L. Therapy in Oncology: An Update on Current Evidence.

Review Cancer
Thronicke A et al (2022).
Complement Med Res.
PubMed:
35325897

The gene space of European mistletoe (Viscum album).

Schröder L et al (2022).
Plant J.
PubMed:
34713513

In vivo effects of Viscum album and probiotics against carbon tetrachloride-induced liver injury.

Erdaş M et al (2021).
J Bioenerg Biomembr.
PubMed:
33625632

[Mistletoe in the treatment of cancer patients].

Review Cancer
Rostock M et al (2020).
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz.
PubMed:
32211937

Chemical Pleurodesis Using Doxycycline and Viscum album Extract.

Song KS, Keum D and Kim JB (2017).
Korean J Thorac Cardiovasc Surg.
PubMed:
28795034