Vitex agnus-castus

Common Names: lilac chastetree

Ethnobotanical Studies

Shouf Biosphere Reserve, Lebanon

Uses: Premenstrual symptoms, Prostate, Hypertrophy, Constipation, Irritability, Migraines, Breast pain, Tenderness, Depression, Abdominal cramps, Diarrhea, Increased menstrual flow, Pruritus, Acne, Female infertility, Menopause, Low lipid

DOI:: 10.1186/s13002-022-00568-y
PubMed:: 36572929

Clinical Trials

Effects of a combination of botanical actives on skin health and antioxidant status in post-menopausal women: A randomized, double-blind, placebo-controlled clinical trial.

Researchers investigated the use of nutraceuticals with estrogenic and antioxidative effects as an alternative therapy to slow down skin aging in post-menopausal women.

Tumsutti P et al (2022).; J Cosmet Dermatol.
DOI:: 10.1111/jocd.14345
PubMed:: 34260808

Therapeutic effect of Vitex agnus castus in patients with premenstrual syndrome.

Zamani M, Neghab N and Torabian S (2012).; Acta Med Iran.
PubMed:: 22359078

Studies

Evaluation of the anti-obesity effect of Sambucus nigra L. (elderberry) and Vitex agnus-castus L. (chasteberry) extracts in high-fat diet-induced obese rats.

Summary

Study investigated effects of L. and L. plant extracts on obesity-induced rats. Ethanol extracts of L. flowers and leaves, as well as water extract of L. leaves, showed potential benefits in treating obesity. Further clinical studies needed to confirm efficacy.

Obesity

Ulusoy Ş et al (2024).; Front Pharmacol.
DOI:: 10.3389/fphar.2024.1410854
PubMed:: 39055496

Performance of vertical flow constructed wetland for the treatment of effluent from a brassware industry in city of Fez, Morocco: a laboratory scale study.

Zoufri I et al (2024).; Int J Phytoremediation.
DOI:: 10.1080/15226514.2024.2338137
PubMed:: 38591171

Use of Vitex agnus-castus in patients with menstrual cycle disorders: a single-center retrospective longitudinal cohort study.

Höller M et al (2024).; Arch Gynecol Obstet.
DOI:: 10.1007/s00404-023-07363-4
PubMed:: 38393671

Plant-related Philistine ritual practices at biblical Gath.

Frumin S et al (2024).; Sci Rep.
DOI:: 10.1038/s41598-024-52974-9
PubMed:: 38347005

Vitex Genus as a Source of Antimicrobial Agents.

Summary

L. species are used in traditional medicine for infectious diseases. They exhibit antimicrobial activity against various pathogens, containing potential antimicrobial compounds. Further research is required.

Review Antimicrobial

Islam Z et al (2024).; Plants (Basel).
DOI:: 10.3390/plants13030401
PubMed:: 38337934

Effects of the PREMEN-CALM® in the Management of the Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.

Herrera A et al (2024).; J Diet Suppl.
DOI:: 10.1080/19390211.2023.2301398
PubMed:: 38213037

Evaluation of the therapeutic efficacy of Vitex agnus-castus extract on cisplatin-induced hematotoxicity in female Wistar rats.

Tripathy A et al (2023).; Vet World.
DOI:: 10.14202/vetworld.2023.2186-2191
PubMed:: 38152275

Vitex agnus castus effects on hyperprolactinaemia.

Review

Puglia LT, Lowry J and Tamagno G (2023).; Front Endocrinol (Lausanne).
DOI:: 10.3389/fendo.2023.1269781
PubMed:: 38075075

The effects of titanium dioxide (TiO(2)) nanoparticles on physiological, biochemical, and antioxidant properties of Vitex plant (Vitex agnus - Castus L).

Summary

Spraying titanium dioxide nanoparticles on plants improved root and shoot growth but reduced leaf weight. It also increased chlorophyll levels and antioxidant enzyme activity without affecting proline and soluble protein content, suggesting potential benefits for plant growth and biochemical properties.

Immunology

Moshirian Farahi SM et al (2023).; Heliyon.
DOI:: 10.1016/j.heliyon.2023.e22144
PubMed:: 38034643

10.

Vitagnus an estrogen-riched herbal remedy used in sexual dysfunction: A randomized clinical trial.

Summary

Study in Iran: Vitagnus, a herb with phytoestrogens, evaluated for treating sexual dysfunction in postmenopausal women. Results indicated potential efficacy in improving sexual dysfunction.

Endocrinology

Zohreh A et al (2023).; J Educ Health Promot.
DOI:: 10.4103/jehp.jehp_870_22
PubMed:: 37849864

11.

Efficacy and Tolerability Evaluation of a Nutraceutical Composition Containing Vitex agnus-castus Extract (EVX40™), Pyridoxine, and Magnesium in Premenstrual Syndrome: A Real-World, Interventional, Comparative Study.

Sureja VP et al (2023).; Cureus.
DOI:: 10.7759/cureus.42832
PubMed:: 37664371

12.

Analysis of Safety Concerns on Herbal Products with Assumed Phytoestrogenic Activity.

Endocrinology

Tjeerdsma AM et al (2023).; Pharmaceuticals (Basel).
DOI:: 10.3390/ph16081137
PubMed:: 37631050

13.

First report of leaf spot on Chaste-Tree Caused by Alternaria alternata in China.

Wang W et al (2023).; Plant Dis.
DOI:: 10.1094/PDIS-07-23-1398-PDN
PubMed:: 37580887

14.

Phyto-progestins for the treatment of abnormal uterine bleeding without organic cause in women at high risk for breast cancer and breast cancer survivors: a prospective, pilot study.

Summary

Researchers studied the effects of DV, VAC, and D plants on breast cancer survivors or those with genetic risk factors experiencing unexplained uterine bleeding. Results could have implications for treatment options.

Cancer

Grandi G et al (2023).; Gynecol Endocrinol.
DOI:: 10.1080/09513590.2023.2239936
PubMed:: 37494965

15.

Wild Vitex agnus-castus L.: Phytochemical Characterization, Acute Toxicity, and Bioactive Properties.

Phytochemistry

Boujbiha MA et al (2023).; Molecules.
DOI:: 10.3390/molecules28135096
PubMed:: 37446759

16.

Suspected cutaneous adverse drug reactions reported with traditional medicines: analysis of data for United Nations Asia region from WHO VigiBase.

Barvaliya MJ et al (2023).; Front Pharmacol.
DOI:: 10.3389/fphar.2023.1088841
PubMed:: 37324461

17.

A comprehensive review on clinically proven natural products in the management of nerve pain, with mechanistic insights.

Summary

Researchers investigated the use of non-pharmacological interventions for neuropathic pain as an alternative to current drugs. Their findings may offer more effective and safer treatment options for patients.

Review Pain

Dewanjee S et al (2023).; Heliyon.
DOI:: 10.1016/j.heliyon.2023.e15346
PubMed:: 37159686

18.

Evaluation of Anti-Candida albicans Activities of Herbal Preparations Sold at the Kumasi Central Market in the Ashanti Region of Ghana.

Domfeh SA, Kyeremeh G and Belifini M (2023).; Evid Based Complement Alternat Med.
DOI:: 10.1155/2023/6162532
PubMed:: 37082250

19.

Chaste Tree.

Review

(2023).
PubMed:: 36745730

20.

Green Synthesis of Silver Nanoparticles Using the Plant Extracts of Vitex Agnus Castus L: An Ecofriendly Approach to Overcome Antibiotic Resistance.

Antimicrobial

Ghani S et al (2022).; Int J Prev Med.
DOI:: 10.4103/ijpvm.ijpvm_140_22
PubMed:: 36452468

21.

The Effectiveness of Herbal Medicines on Cyclic Mastalgia: A Systematic Review on Meta-analysis.

Meta-Analysis

Mirzaee F et al (2022).; Rev Bras Ginecol Obstet.
DOI:: 10.1055/s-0042-1755456
PubMed:: 36446563

22.

Colonic Obstruction Secondary to Phytobezoar Caused by Vitex Agnus-Castus Seeds: A Case Report.

Somuncu E and Solak IHA (2022).; J Coll Physicians Surg Pak.
DOI:: 10.29271/jcpsp.2022.Supp2.S115
PubMed:: 36210666

23.

Anticholinergic, Antioxidant, and Antibacterial Properties of Vitex Agnus-Castus L. Seed Extract: Assessment of Its Phenolic Content by LC/MS/MS.

Phytochemistry

Kavaz A et al (2022).; Chem Biodivers.
DOI:: 10.1002/cbdv.202200143
PubMed:: 36075867

24.

Polycystic ovaries and herbal remedies: A systematic review.

Review Endocrinology

Manouchehri A et al (2022).; JBRA Assist Reprod.
DOI:: 10.5935/1518-0557.20220024
PubMed:: 35916457

25.

Traditional Medicinal Uses, Phytochemistry, Biological Properties, and Health Applications of Vitex sp.

Review Phytochemistry

Kamal N et al (2022).; Plants (Basel).
DOI:: 10.3390/plants11151944
PubMed:: 35893648

26.

Does Vitex Agnus-Castus L. Have Deleterious Effect on Fertility and Pregnancy Outcome? An Experimental Study on Rats for Prediction of Its Safety.

Najib FS et al (2022).; J Pharmacopuncture.
DOI:: 10.3831/KPI.2022.25.2.106
PubMed:: 35837144

27.

Narrative review of Vitex agnus-castus in symptoms in Gynecology.

Review

Mendes C et al (2022).; Rev Assoc Med Bras (1992).
DOI:: 10.1590/1806-9282.20220174
PubMed:: 35584503

28.

Phylogeny-Aware Chemoinformatic Analysis of Chemical Diversity in Lamiaceae Enables Iridoid Pathway Assembly and Discovery of Aucubin Synthase.

Rodríguez-López CE et al (2022).; Mol Biol Evol.
DOI:: 10.1093/molbev/msac057
PubMed:: 35298643

29.

Herbal Products Used in Menopause and for Gynecological Disorders.

Review Endocrinology

Kenda M et al (2021).; Molecules.
DOI:: 10.3390/molecules26247421
PubMed:: 34946512

30.

Vitex agnus-castus in premenstrual syndrome: A meta-analysis of double-blind randomised controlled trials.

Meta-Analysis

Csupor D et al (2019).; Complement Ther Med.
DOI:: 10.1016/j.ctim.2019.08.024
PubMed:: 31780016

31.

Chasteberry.

Review

(2022).
PubMed:: 30000866

32.

Vitex agnus castus for premenstrual syndrome and premenstrual dysphoric disorder: a systematic review.

Review

Cerqueira RO et al (2017).; Arch Womens Ment Health.
DOI:: 10.1007/s00737-017-0791-0
PubMed:: 29063202

33.

Systematic Review of Premenstrual, Postmenstrual and Infertility Disorders of Vitex Agnus Castus.

Review

Rafieian-Kopaei M and Movahedi M (2017).; Electron Physician.
DOI:: 10.19082/3685
PubMed:: 28243425

34.

The treatment of premenstrual syndrome with preparations of Vitex agnus castus: a systematic review and meta-analysis.

Meta-Analysis

Verkaik S et al (2017).; Am J Obstet Gynecol.
DOI:: 10.1016/j.ajog.2017.02.028
PubMed:: 28237870

35.

Botanicals and Their Bioactive Phytochemicals for Women's Health.

Review Phytochemistry

Dietz BM et al (2016).; Pharmacol Rev.
PubMed:: 27677719

36.

Adverse effects of herbal medicines: an overview of systematic reviews.

Review

Posadzki P, Watson LK and Ernst E (2013).; Clin Med (Lond).
PubMed:: 23472485

37.

Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials.

Review

van Die MD et al (2013).; Planta Med.
DOI:: 10.1055/s-0032-1327831
PubMed:: 23136064

38.

Vitex agnus castus: a systematic review of adverse events.

Review

Daniele C et al (2005).; Drug Saf.
PubMed:: 15783241