Vitex negundo

Common Names: Chinese chastetree

Ethnobotanical Studies

Studies

Vitexin promotes the anti-senescence effect via inhibiting JAK2/STAT3 in D-Galactose-induced progeria mice and stress-induced premature senescence.

Immunology
Han X et al (2024).
Eur J Pharmacol.
DOI:
10.1016/j.ejphar.2024.176865
PubMed:
39084453

Phytochemicals, antioxidant ability and in vitro anthelmintic activity of crude extracts from Vitexnegundo leaves against Haemonchus contortus.

Summary

Study evaluated effectiveness of different extracts of leaves on worm eggs and larvae. Results show potential for natural anthelmintic treatment, with possibility for further research and development for parasite control.

Immunology
Khan FA et al (2024).
J Parasit Dis.
DOI:
10.1007/s12639-024-01660-8
PubMed:
38840874

Polymethoxylated flavones from the leaves of Vitex negundo have fungal-promoting and antibacterial activities during the production of broad bean koji.

Liu J et al (2024).
Front Microbiol.
DOI:
10.3389/fmicb.2024.1401436
PubMed:
38751721

Photo-catalytic dye degradation potentials of Ag-Pd bimetallic nanoparticles synthesized from Vitex negundo.

Narenkumar J et al (2024).
Environ Geochem Health.
DOI:
10.1007/s10653-024-01978-5
PubMed:
38696110

Repellent activity of Vitex negundo and Curcuma longa herbal extract against simulium species in India.

Bhuyan C, Saha D and Rabha B (2024).
J Vector Borne Dis.
DOI:
10.4103/JVBD.JVBD_181_23
PubMed:
38634372

Chemical profiling of bioactive compounds in the methanolic extract of wild leaf and callus of Vitex negundo using gas chromatography-mass spectrometry.

Phytochemistry
Garg G et al (2024).
World J Exp Med.
DOI:
10.5493/wjem.v14.i1.88064
PubMed:
38590309

Mitigation of letrozole induced polycystic ovarian syndrome associated inflammatory response and endocrinal dysfunction by Vitex negundo seeds.

Summary

Researchers studied the use of Vitex negundo seed in treating polycystic ovary syndrome in rats. Results may offer safer and more effective treatment options for PCOS in women.

EndocrinologyImmunology
Kar TK et al (2024).
J Ovarian Res.
DOI:
10.1186/s13048-024-01378-4
PubMed:
38589892

The dynamics of nocturnal sap flow components of a typical revegetation shrub species on the semiarid Loess Plateau, China.

Fang W et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2024.1370362
PubMed:
38576789

Triterpenoids and triterpenoid saponins from Vitex negundo and their anti-inflammatory activities.

Summary

Scientists isolated new compounds from Vitex negundo plant, determined structures by analysis. Vitnegundins A, E, and swinhoeic acid show potential for inhibiting inflammation. Consider for anti-inflammatory drug development.

ImmunologyPhytochemistry
Gu C et al (2024).
Phytochemistry.
DOI:
10.1016/j.phytochem.2024.114068
PubMed:
38554895

Correction to "Mating strategies of Vitex negundo L. var. heterophylla (Franch.) Rehder (Lamiaceae): A mixed mating system with inbreeding depression".

Summary

Scientists studied the effects of climate change on butterflies' host plants. They found that increased CO2 levels could lead to decreased plant quality, affecting butterfly populations. Important for understanding how climate change impacts ecosystems.

Neuroscience
(2024).
Ecol Evol.
DOI:
10.1002/ece3.11165
PubMed:
38500860

Mating strategies of Vitex negundo L. var. heterophylla (Franch.) Rehder (Lamiaceae): A mixed mating system with inbreeding depression.

Summary

Scientists studied the reproductive characteristics of var. to understand its mating system and pollination patterns. Results show a mixed mating system dominated by outcrossing, with low seed germination in inbred lines. This research is crucial for conservation of plant diversity and ecosystem protection.

Neuroscience
Zhang Q et al (2024).
Ecol Evol.
DOI:
10.1002/ece3.10927
PubMed:
38414571

Vitex Genus as a Source of Antimicrobial Agents.

Summary

L. species are used in traditional medicine for infectious diseases. They exhibit antimicrobial activity against various pathogens, containing potential antimicrobial compounds. Further research is required.

Review Antimicrobial
Islam Z et al (2024).
Plants (Basel).
DOI:
10.3390/plants13030401
PubMed:
38337934

Unveiling the healing properties of 2,3-dehydrosilychristin: a potential silymarin-derived flavonolignan from Vitex negundo.

Tripathi N et al (2024).
Nat Prod Res.
DOI:
10.1080/14786419.2024.2312542
PubMed:
38333925

Vitex Negundo-Fe(3)O(4)-CuO green nanocatalyst (VN-Fe(3)O(4)-CuO): synthesis of pyrazolo[3,4-c]pyrazole derivatives via the cyclization of isoniazid with pyrazole and their antimicrobial activity, cytotoxicity, and molecular docking studies.

Summary

Scientists developed a new compound with potential as a treatment for infectious diseases. It showed strong antibacterial and antifungal activity, better than standard drugs, along with low cytotoxicity. Molecular docking and dynamics simulations supported its efficacy. The compound was synthesized using a nanocatalyst.

Antimicrobial
Akbar I et al (2024).
RSC Adv.
DOI:
10.1039/d3ra06771h
PubMed:
38173593

Effect of E-PR-01 on non-specific low back pain in the adult population: A randomized, double-blind, placebo-controlled, parallel-group trial.

Summary

Researchers studied the impact of low back pain on work productivity and quality of life, highlighting the importance of addressing this issue for public health and making informed decisions for the lab.

Pain
Srivastava S, Karvir S and Girandola RN (2023).
J Back Musculoskelet Rehabil.
DOI:
10.3233/BMR-230197
PubMed:
38073372

Chemical Diversity and Medicinal Potential of Vitex negundo L.: From Traditional Knowledge to Modern Clinical Trials.

Sharma D et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202301086
PubMed:
37851484

Evaluation of the anti-inflammatory and antioxidant properties, and the isolation and characterization of a new bioactive compound, 3,4,9-trimethyl-7-propyldecanoic acid, from Vitex negundo.

Immunology
Sivapalan S et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117314
PubMed:
37832812

Secondary succession of shrub-herb communities in the hilly area of Taihang Mountain.

Liu X et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1194083
PubMed:
37746017

Responses of sap flow density of two shrub species to rainfall classes on the semiarid Loess Plateau of China.

Fang W et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1237248
PubMed:
37636114

Effect of E-PR-01 on Activity-Induced Acute Knee Joint Discomfort in Healthy Individuals: A Randomized, Placebo-Controlled, Double-Blind, Cross-Over Study.

Srivastava S and Girandola RN (2023).
J Pain Res.
DOI:
10.2147/JPR.S412018
PubMed:
37384126

Cardioprotective Effects of Vitex negundo: A Review of Bioactive Extracts and Compounds.

Summary

Scientists reviewed the potential use of a medicinal plant known as in treating cardiovascular diseases. Previous studies suggest that and its active components have protective effects, but more research is needed to validate their use and explore potential side effects.

Review Cardiology
Nyamweya B et al (2023).
J Evid Based Integr Med.
DOI:
10.1177/2515690X231176622
PubMed:
37279951

Microbial gradual shifts during the process of species replacement in Taihang Mountain.

Liu X et al (2023).
Front Microbiol.
DOI:
10.3389/fmicb.2023.1158731
PubMed:
37089536

A network pharmacology and molecular docking approach in the exploratory investigation of the biological mechanisms of lagundi (Vitex negundo L.) compounds against COVID-19.

Summary

Researchers used network pharmacology and molecular docking to identify potential targets of Vitex negundo compounds against COVID-19. Results suggest that these compounds may interact with important proteins involved in the disease. However, further research is needed to fully understand their mechanisms and effectiveness.

COVID-19
Rivera RG et al (2023).
Genomics Inform.
DOI:
10.5808/gi.22060
PubMed:
37037462

Vitexin suppresses the proliferation, angiogenesis and stemness of endometrial cancer through the PI3K/AKT pathway.

Cancer
Liang C, Jiang Y and Sun L (2023).
Pharm Biol.
DOI:
10.1080/13880209.2023.2190774
PubMed:
36994813

Pharmacoinformatics-based screening of active compounds from Vitex negundo against lymphatic filariasis by targeting asparaginyl-tRNA synthetase.

Kabilan SJ et al (2023).
J Mol Model.
DOI:
10.1007/s00894-023-05488-6
PubMed:
36872402

Toxicity Profiling and Antihyperuricemic Activity of Goubion: A Polyherbal Formulation.

Sadia H et al (2023).
Evid Based Complement Alternat Med.
DOI:
10.1155/2023/7088628
PubMed:
36846052

Total lignans from Vitex negundo seeds attenuate osteoarthritis and their main component vitedoin A alleviates osteoclast differentiation by suppressing ERK/NFATc1 signaling.

Phytochemistry
Ban Y et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7750
PubMed:
36737044

Ecological function of key volatiles in Vitex negundo infested by Aphis gossypii.

Xu Q et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2022.1090559
PubMed:
36714696

Anti-bacterial Effect and Characteristics of Gold Nanoparticles (AuNps) Formed with Vitex negundo Plant Extract.

Shanwaz MM and Shyam P (2023).
Appl Biochem Biotechnol.
DOI:
10.1007/s12010-022-04217-8
PubMed:
36355335

Agnuside Alleviates Synovitis and Fibrosis in Knee Osteoarthritis through the Inhibition of HIF-1α and NLRP3 Inflammasome.

Zhang L et al (2021).
Mediators Inflamm.
DOI:
10.1155/2021/5534614
PubMed:
33814979

Vitex negundo Linn. extract alleviates inflammatory aggravation and lung injury by modulating AMPK/PI3K/Akt/p38-NF-κB and TGF-β/Smad/Bcl2/caspase/LC3 cascade and macrophages activation in murine model of OVA-LPS induced allergic asthma.

Summary

Researchers studied the potential of Vitex negundo Linn., a medicinal plant, in managing allergic respiratory diseases. Its anti-tussive and bronchodilator properties suggest it could be beneficial for asthma. However, more scientific research is needed to understand its exact attributes and mechanism of action.

AsthmaImmunology
Tirpude NV et al (2021).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2021.113894
PubMed:
33516930

Vitex negundo inhibits cyclooxygenase-2 inflammatory cytokine-mediated inflammation on carrageenan-induced rat hind paw edema.

Immunology
Chattopadhyay P et al (2012).
Pharmacognosy Res.
DOI:
10.4103/0974-8490.99072
PubMed:
22923950

Tris(2,4-di-tert-butyl-phen-yl) phosphate.

Vinuchakkaravarthy T, Sangeetha CK and Velmurugan D (2010).
Acta Crystallogr Sect E Struct Rep Online.
DOI:
10.1107/S1600536810029673
PubMed:
21588579