Vitex trifolia

Common Names: simpleleaf chastetree

Ethnobotanical Studies

Studies

Discovery of a novel natural compound, vitekwangin B, with ANO1 protein reduction properties and anticancer potential.

Summary

Vitekwangin B shows promise in inhibiting ANO1 protein levels in prostate cancer and NSCLC cells, potentially offering a new therapy option with minimal toxicity and resistance issues. More research needed.

Cancer
Seo Y et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1382787
PubMed:
38659592

A comprehensive review of ethnomedicinal approaches, phytochemical analysis, and pharmacological potential of Vitex trifolia L.

Summary

Verbenaceae plants, including L. (), have diverse therapeutic potential for chronic diseases. Phytochemical analyses show terpenoids and flavonoids as main bioactives. Pharmacological studies confirm antioxidant, anti-inflammatory, anticancer properties. This review bridges traditional knowledge with modern research to support future healthcare applications.

Review EthnobotanyPhytochemistry
Mottaghipisheh J et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1322083
PubMed:
38576489

Biological Potential and Therapeutic Effectiveness of Artemetin from Traditional to Modern Medicine: An Update on Pharmacological Activities and Analytical Aspects.

Patel K and Patel DK (2024).
Recent Adv Antiinfect Drug Discov.
DOI:
10.2174/0127724344266027231215105620
PubMed:
38275071

Efficacy and safety of Weichang' an pill combined with Western Medicine on gastrointestinal diseases: a systematic review and Meta-analysis.

Jiabao W et al (2023).
J Tradit Chin Med.
DOI:
10.19852/j.cnki.jtcm.20230814.003
PubMed:
37946467

Three Undescribed Iridoid derivatives Isolated from The Fruits of Vitex trifolia with Their Cytotoxic and Antimicrobial Activities.

Summary

Scientists isolated nine iridoid derivatives from the fruits of Vitex trifolia L., a medicinal plant in Vietnam. Four of the compounds showed significant antibacterial activity against various strains, while all nine compounds were not cytotoxic to lung cancer cells.

Antimicrobial
Huong PTT et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202301296
PubMed:
37842907

Traditional use, phytochemistry and pharmacology of Viticis Fructus.

Summary

This review discusses the research progress on Viticis Fructus, a traditional Chinese medicine used to treat various illnesses. It examines its botany, ethnopharmacology, phytochemistry, and pharmacological activity to provide insights into its potential benefits.

Review Phytochemistry
Meng X et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e19144
PubMed:
37810114

[Comparison of HPLC fingerprints and determination of main components of Viticis Fructus from different species].

Yang XY et al (2023).
Zhongguo Zhong Yao Za Zhi.
DOI:
10.19540/j.cnki.cjcmm.20230104.201
PubMed:
37282876

Simultaneous quantitative analysis of 11 constituents in Viticis Fructus by HPLC-HRMS and HPLC-DAD combined with chemometric methods.

Wu T et al (2023).
Phytochem Anal.
DOI:
10.1002/pca.3190
PubMed:
36433771

Acetylcholinesterase Inhibitory Activities of Essential Oils from Vietnamese Traditional Medicinal Plants.

Summary

This study evaluated essential oils from several plants in the Lamiaceae family for their ability to inhibit the enzyme acetylcholinesterase (AChE), which is important for treating Alzheimer's disease and as a safe pesticide. The results showed promising activity in the oils of some species, which could potentially control mosquito vectors that transmit pathogenic viruses or support Alzheimer's treatment. Molecular simulations were also performed to investigate how the oils may work to inhibit AChE.

NeurosciencePhytochemistry
Hung NH et al (2022).
Molecules.
DOI:
10.3390/molecules27207092
PubMed:
36296686

Vitex trifolia L. modulates inflammatory mediators via down-regulation of the NF-κB signaling pathway in carrageenan-induced acute inflammation in experimental rats.

Immunology
Annamalai P and Thangam EB (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115583
PubMed:
36028166

Diterpenoids with α-glucosidase inhibitory activities from the fruits of Vitex trifolia Linn.

Djimabi K et al (2022).
Fitoterapia.
DOI:
10.1016/j.fitote.2022.105248
PubMed:
35777590

Effects of revegetation on the composition and diversity of bacterial and fungal communities of sandification land soil, in Southern China.

Long H et al (2021).
Environ Monit Assess.
DOI:
10.1007/s10661-021-09508-x
PubMed:
34623532

New Xanthones with Antiagricultural Fungal Pathogen Activities from the Endophytic Fungus Diaporthe goulteri L17.

Peng X et al (2021).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.1c03513
PubMed:
34541846

The Cyr61 Is a Potential Target for Rotundifuran, a Natural Labdane-Type Diterpene from Vitex trifolia L., to Trigger Apoptosis of Cervical Cancer Cells.

CancerPhytochemistry
Gong G et al (2021).
Oxid Med Cell Longev.
DOI:
10.1155/2021/6677687
PubMed:
34234887

Comprehensive identification of Vitex trifolia fruit and its five adulterants by comparison of micromorphological, microscopic characteristics, and chemical profiles.

Li XX et al (2020).
Microsc Res Tech.
DOI:
10.1002/jemt.23547
PubMed:
32734676

Effects of Vitex trifolia L. leaf extracts and phytoconstituents on cytokine production in human U937 macrophages.

Immunology
Wee HN et al (2020).
BMC Complement Med Ther.
DOI:
10.1186/s12906-020-02884-w
PubMed:
32188443

Selected hepatoprotective herbal medicines: Evidence from ethnomedicinal applications, animal models, and possible mechanism of actions.

Review Ethnobotany
Ali M et al (2018).
Phytother Res.
DOI:
10.1002/ptr.5957
PubMed:
29047177

Aqueous extract of Vitex trifolia L. (Labiatae) inhibits LPS-dependent regulation of inflammatory mediators in RAW 264.7 macrophages through inhibition of Nuclear Factor kappa B translocation and expression.

Immunology
Matsui M et al (2012).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2012.05.043
PubMed:
22732725