Common Names: withania
Study demonstrates potential benefits of liposomal ashwagandha supplementation on cognitive function and mood in young adults. May be useful for reducing stress and cognitive decline in younger populations.
Researchers conducted a randomized, double-blind, placebo-controlled study to investigate the effects of ashwagandha on cognitive function in adults aged 35-85 years. The study consisted of 50 participants who received either 300 mg of ashwagandha or a placebo twice daily for 8 weeks. Cognitive function was measured using various tests. The study found that the ashwagandha group had significant improvement in tests related to executive function, attention, and information processing speed compared to the placebo group. No adverse effects were reported. These findings suggest that ashwagandha may have potential as a safe and effective supplement for improving cognitive function in older adults. However, larger and longer-term studies are needed to confirm these results.
The study explored Withania somnifera's anti-microbial, anti-neuropathic, and anti-inflammatory activities. Withanolide A was identified as the most active compound. Nano-cubosomes improved its efficacy, particularly CUB 3, showing potential as a drug-delivery system for neuropathy and inflammation.
Unani remedies offer safer alternatives to conventional drugs for treating neurodegenerative disorders, with evidence supporting their efficacy in alleviating symptoms and providing neuroprotective benefits from natural phytoconstituents.
Researchers studied medicinal plants for potential COVID-19 treatment. Plants with antioxidant, anti-inflammatory, and immunomodulatory effects were investigated as inhibitors of the virus. This research could lead to effective treatments for COVID-19.
Study analyzed biological activity of WSME plant extract, traditionally used in Ayurveda, for potential medicinal benefits. Important for exploring natural remedies for various health conditions.
Researchers studied the impact of functional constipation on quality of life and mental health. The gut-brain axis plays a role in functional gastrointestinal disorders. Traditional treatments have limitations, leading to interest in herbal supplements like ashwagandha and okra for symptom management.
Significant advancements in drug technology have led to promising anti-breast cancer properties of Withania somnifera. It can be used as a prophylactic or therapeutic adjunct to improve treatment outcomes and understanding of breast cancer progression.
"We studied the effects of L. (WS) plant extracts on colon cancer cells, finding potential as anticancer agents. Further research is needed to validate these findings for clinical use."
Penconazole fungicide leaves harmful residues on crops, causing neurotoxicity. Withania somnifera extract improves brain function. WSLE nanoemulsion enhances blood-brain barrier penetration, reducing neurotoxic effects of Penconazole.
Review of dietary supplements affecting testosterone levels. Two extracts, Withania somnifera and Trigonella foenum-graecum, shown to increase T levels in men through different mechanisms. Important for selecting effective supplements for lab use.
Review explores multifaceted pathophysiology of Alzheimer's disease, including cholinergic, tau protein, Aβ, oxidative stress, and metal ion hypotheses. Herbal interventions show potential for neuroprotection, but face limitations. DHA and Nicotine also show promise. Future research needed.
Study finds potential benefits of medicinal plants like Curcuma longa, Syzygium aromaticum, and Zingiber officinale in treating rheumatoid arthritis due to antioxidant and anti-inflammatory properties, offering safer alternative to conventional treatments.
Researchers explored Withanone, a compound in Withania somnifera, as a potential safe cancer treatment. In silico and in vitro studies suggest anticancer activities and selective killing of cancer cells. Further research is needed for in vivo experiments and toxicity evaluation.
Withania somnifera (WS) has potent immunomodulatory, anticancer, and antiviral properties against COVID-19, especially in cancer patients. Withanolides in WS extract show promising cytotoxicity against SARS-CoV-2 and pro-inflammatory markers. Further research is needed for potential therapy.
Adaptogens are plants that help the body adapt to stress and promote resilience. They have anti-inflammatory effects and may improve conditions in central nervous system disorders. Research aims to understand their benefits on neuroinflammation.
Researchers discovered a potent fungus from roots that can inhibit breast cancer cell growth. The fungus synthesizes bioactive compounds, and several lead compounds were identified as potential anti-cancer agents. This study suggests the fungus could be used to develop new chemotherapy drugs.
Researchers have been studying the development of vaccines, repurposing approved drugs, and natural compounds for COVID-19. Gender differences in disease severity suggest that sex hormones could be involved. Androgens upregulate ACE2, a key receptor for the virus, while androgen antagonists can lower ACE2 levels, potentially aiding in COVID-19 management.
This article reviews the use of natural compounds like curcumin, wolfberry, ginseng, and Withania somnifera to treat neurodegenerative diseases. These compounds have strong anti-inflammatory and anti-oxidant properties that can prevent neurological dysfunction and improve neuronal function.
This study assessed nutraceutical/phytoceutical augmentation strategies for schizophrenia. Sarcosine, citicoline, and N-acetylcysteine showed promise in improving symptoms, but more high-quality trials are needed.
This study examined the effects of adding Ashwagandha and Shatavari to the diet of fish. The results showed that the addition of these herbs improved growth indices, increased enzyme activity, and upregulated myogenic regulatory factors. These findings have potential implications for aquaculture.
Bioinformatics tools identified early detection biomarkers for colorectal cancer and explored plant extract as a chemotherapy alternative. Three diagnostic markers identified, with positive trends in gene expression and therapeutic value. Further trials required. Precise and robust analysis workflow valuable for CRC diagnosis and treatment decisions.
Researchers found that TC + PL extract reduced insulin resistance and liver weight in mice, while Saroglitazar reversed body weight and lipid level changes. These extracts hold promise for preventing obesity-related complications.
Ashwagandha root extract with standardized withanolides and piperine improved depression, anxiety, sleep quality, and quality of life compared to placebo. It increased serotonin levels and was well-tolerated.
This study shows that stress in plant cells affects RNA editing, specifically in the mitochondria gene responsible for the b subunit of ATP synthase. Polar edits in the b subunit help stabilize the complex and potentially impact ATPase activity, suggesting they aim to restore the active protein.
This study evaluated the prevalence and characteristics of adverse events associated with adaptogen-antidepressant interactions. Adaptogens were involved in 9% of adverse events. Clinicians should monitor these interactions due to the potential for clinically significant adverse events.
Researchers synthesized nitrogen-doped carbon dots from Withania somnifera, which showed improved fluorescence properties and potential for inhibiting SARS-CoV pseudoviron cells. Mechanism of action understanding is crucial for their potential use against Covid-19.
Researchers developed a multifunctional composite using tadalafil-loaded nanoparticles (NPs) and ashwagandha extract in nanofibers. It improved wound closure, reduced inflammation, and enhanced angiogenesis in diabetic rats, offering potential as a diabetic wound dressing.
Tldr: Withaferin A (WA), a compound from a dietary supplement, shows significant anti-tumor effects by inhibiting cell cycle, apoptosis, metastasis, and angiogenesis. It has potential targets for cancer treatment, but toxicity and bioavailability issues need addressing. Further research on its exact mechanism is crucial.
52 studies on testosterone boosters were reviewed, revealing that most do not increase total testosterone. However, β-hydroxy β-methylbutyrate and betaine proved effective for male athletes, and Eurycoma longifolia and Withania somnifera may be effective for other populations. This information should be considered for lab decisions.
MSG can cause neurotoxicity, but ashwagandha (ASH) has memory-enhancing properties. ASH improved spatial memory and increased NMDAR levels in rats, suggesting potential therapy against MSG-induced memory impairment. ASH may protect against neurotoxicity and enhance spatial learning.
Saudi scientists identify potential anti-epileptic compounds from local flora using network pharmacology and bioinformatics, supported by molecular docking experiments. This research informs future development of epilepsy treatments.
This review explores the use of African fruits in traditional medicine and their potential as anticancer agents. It emphasizes the importance of further research and suggests that these fruits could provide valuable phytochemicals for anticancer studies.
Ashwagandha is a natural herb known as an adaptogen that aids in managing stress. It is safe and effective, making it beneficial for stress relief.
Ayurveda treatments used in India during COVID-19 showed positive outcomes in aiding early recovery from the virus.
Researchers developed and validated a method to measure biomarkers in a popular supplement. The method is sensitive, accurate, and efficient, providing valuable information for future studies and trials.
Ashwagandha, an Ayurvedic plant, has therapeutic properties but lacks studies using genetic models of diseases to validate its effectiveness in treating cancer, diabetes, inflammation, and neurodegenerative diseases.
Summary: This review evaluated the current evidence on the health benefits of Withania somnifera (Ws) supplementation in healthy adults. Most studies reported that Ws supplementation reduced oxidative stress and inflammation, regulated hormone levels, and had no serious adverse events. However, more research is needed to fully understand its application.
Researchers studied the effects of WS root extract on airway remodeling in a rat model of asthma. The extract showed potential in reducing structural changes and improving airflow limitation, offering new therapeutic options for asthma treatment.
Review finds that plant-based drugs, particularly herbs, used as add-on therapy for COVID-19 show efficacy and safety, potentially enhancing the immune system for treating the virus. (37 words)
In this study, researchers evaluated the sleep-promoting effects of enzyme-treated Ashwagandha root extract (EA). The study found that EA increased sleep duration and improved sleep quality and quantity. It also effectively relieved caffeine-induced insomnia symptoms. The mechanism behind these effects was identified as the activation of the GABAergic system, which is involved in sleep regulation. This research suggests that EA could be used as a functional material to improve sleep deprivation.
Withaferin-A (WA), found in Ashwagandha, has anti-inflammatory properties. It was tested in a mouse model of acute graft versus host disease (aGvHD) after stem cell transplants. The mice given WA had fewer symptoms and better survival than the control group. They also had better survival than those given the standard treatment. WA reduced inflammatory cytokines and increased anti-inflammatory cytokines. It also protected organs from damage. WA could be a useful treatment for aGvHD and should be studied in clinical trials.
Study on quails reveals Withania somnifera root extract increases estrogen, decreases corticosterone, reduces neuronal apoptosis, and oxidative stress. Prolonged light exposure causes apoptosis and stress, but WS root extract reverses these effects through increased estrogen and ERα expression.
Scientists have discovered that extracts from Physalis pruinosa and P. philadelphica plants have powerful anti-proliferative effects on cells infected with human T-cell leukemia virus I (HTLV-I), which causes adult T-cell leukemia/lymphoma (ATL). Further investigation into the compounds found in these plants led to the discovery of 13 withanolides, including six newly isolated compounds. One of these compounds, withaphysacarpin, demonstrated a comparable effectiveness to the chemotherapy drug etoposide in inhibiting the growth of ATL cells. This research suggests that withanolides could be potential candidates for the treatment of ATL.
This article examines the potential of Wedelia chinensis (WS) as a treatment for COVID-19. WS has shown antiviral effects against SARS-CoV and SARS-CoV-2. It summarizes studies on WS extracts and compounds, and suggests that WS could be a long-term solution to prevent drug resistance.
Plant-based nootropics are natural drugs that can improve cognitive abilities through various mechanisms. They enhance erythrocyte plasticity, inhibit aggregation, and possess antioxidant activity that protects brain tissue from neurotoxicity. They induce the synthesis of neuronal proteins, nucleic acids, and phospholipids for constructing and repairing neurohormonal membranes. The study provides brief descriptions of representative species, their chemical composition, uses, dosages, and contraindications. These plant nootropics have potential therapeutic benefits for treating cognitive disorders, but must be taken at optimal doses for extended periods, and their psychoactive properties are produced by a synergistic combination of several compounds.
Researchers found that traditional Asian medicines, WS and TC, showed potential in combating COVID-19. Among the two, WS proved more effective in protecting against weight loss, viral load, and lung damage. WS also suppressed pro-inflammatory cytokines without harming neutrophil activity, suggesting its potential for treating other acute viral infections.
Bipolar disorder is hindered by cognitive impairment, which can reduce quality of life and socioeconomic functioning. Current treatments for cognitive impairment in bipolar disorder are not effective. However, potential pharmaceutical interventions are being studied to target the underlying biology of the disorder.
This study investigated the effects of Withania somnifera (WS) in preventing the neurotoxicity and memory impairments caused by MDMA. Mice were pretreated with vehicle or WSE before being randomly assigned into four groups: saline, WSE, MDMA alone, or WSE plus MDMA. Mice that were treated with only MDMA showed a decrease in dopamine levels and an increase in gliosis and hyperthermia, leading to memory impairments, while mice treated with both WSE and MDMA showed protection against the noxious effects of MDMA. This study suggests that WSE may be beneficial in counteracting the harmful effects of MDMA on the brain.
Researchers investigated thirty-nine natural compounds found in Ashwagandha, a medicinal plant. They found that Withanoside II is the most effective compound against COVID-19, and Withanoside III, IV, V, X, and XI also have favorable binding affinities. Molecular dynamics simulations confirmed the stable interactions between the compounds and the virus enzymes. The complexes formed between TMPRSS2-Withanolide Q and Mpro-Withanoside IV were the most stable. This research suggests that Ashwagandha compounds may have potential in treating COVID-19.
The gut microbiota's dysbiosis may lead to neurodegenerative diseases like Alzheimer's and Parkinson's due to increased gut and blood-brain barrier permeability. () is a promising plant for treating neurodegenerative diseases and bowel disorders. The researchers identified five proteins and five best lead compounds after molecular docking analysis and simulation studies, revealing HTR1A and HTR7 proteins with the leads Withanolide E and Withanolide A against them, respectively as the most effective targets. Thus by targeting common potential targets, modulation with bioactive compounds present in can result in effective control of these diseases.
A study investigated the potential of dual herbal extracts for their ability to bind to COVID-19 nonstructural proteins (nsp) and to counteract external stimulus. The combination of extracts W and P showed remarkable docking scores and high binding energy for nsp. The extracts also yielded levels of interferon alpha in cell lines to establish an antiviral state. The study suggests that nsp can be targeted with effective antiviral drugs to combat viral RNA synthesis and suppression of host immunity.
Scientists are exploring the use of phytochemicals from medicinal plants as potential therapies against SARS CoV-2 and other coronaviruses. They created a library of 110 phytochemicals from different plants and found that ashwagandha and shatavari contained steroidal saponins and alkaloids that could potentially inhibit the virus's hemagglutinin-acetylesterase (HE) glycoprotein receptor. Molecular docking and dynamics simulations suggest that these phytochemicals could mask the active site of the receptor, preventing viral entry into host cells. This approach has potential for developing therapies against future deadly coronaviruses.