Common Names: spiny cockleburr, Bathurst burr, cocklebur, spiny cocklebur
This study evaluated the antitumor activity of extracts from three plant species: L., L., and L. Using HPLC-MS analysis, the phytochemical profile of the extracts was determined. In vitro screening revealed that L. extracts had the strongest anticancer and antioxidant effects. In vivo assessment using a mouse model showed that administration of L. and green coffee bean extracts reduced ascites cell viability and oxidative stress in tumor samples. Combining chemotherapy with L. or L. extracts induced lipid peroxidation in tumor cells, decreasing tumor viability. These findings suggest that L. extract, especially, has potential as an anticancer agent when used in combination with chemotherapy.