Zanthoxylum armatum

Ethnobotanical Studies

Studies

Genome-wide characterization of RR gene family members in Zanthoxylum armatum and the subsequent functional characterization of the C-type RR.

Hui W et al (2024).
Plant Physiol Biochem.
PubMed:
39032447

Effect of hydroxy-α-sanshool on lipid metabolism in liver and hepatocytes based on AMPK signaling pathway.

Xiang Q et al (2024).
Phytomedicine.
PubMed:
38964152

Genome-wide identification and expression analysis of the BZR gene family in Zanthoxylum armatum DC and functional analysis of ZaBZR1 in drought tolerance.

Jin Z et al (2024).
Planta.
PubMed:
38954109

Genome-Wide Identification and Characterization of the RWP-RK Proteins in Zanthoxylum armatum.

Zheng X et al (2024).
Genes (Basel).
PubMed:
38927601

Green synthesis of silver and iron nano composites using aqueous extract of zanthoxylum armatum seeds and their application for removal of acid black 234 dye.

Bashir N, Gulzar S and Shad S (2024).
Front Toxicol.
PubMed:
38562550

Chemical Composition Variation in Essential Oil and Their Correlation with Climate Factors in Chinese Prickly Ash Peels (Zanthoxylum armatum DC.) from Different Habitats.

Qian Q et al (2024).
Molecules.
PubMed:
38542978

Identification of bioactive compounds of Zanthoxylum armatum as potential inhibitor of pyruvate kinase M2 (PKM2): Computational and virtual screening approaches.

Afzal M et al (2024).
Heliyon.
PubMed:
38495183

Transcriptome analysis reveals key genes and pathways for prickle development in Zanthoxylumarmatum.

Summary

Researchers analyzed prickle development in Xanthoceras sorbifolia and identified key genes and pathways involved in lignification. Understanding this process can help improve management and harvesting of this economically important tree species.

Wang Y et al (2024).
Heliyon.
PubMed:
38486734

Methyl Cinnamate (MC) Alleviates Free Fatty Acids (FFAs) Induced Lipid Accumulation Through the AMPK Pathway in HepG2 Cells.

Fu Y et al (2024).
Diabetes Metab Syndr Obes.
PubMed:
38469107

Study on SH-SY5Y autophagy inhibition and apoptosis induced by methanol extract of Zanthoxylum armatum DC. based on mTOR signal pathway.

Guo J et al (2024).
Toxicol Res (Camb).
PubMed:
38332946

Genomic-wide identification and expression analysis of AP2/ERF transcription factors in Zanthoxylum armatum reveals the candidate genes for the biosynthesis of terpenoids.

Summary

Scientists analyzed the AP2/ERF gene family in Zanthoxylum armatum leaves. Four genes were identified as potentially involved in terpenoid biosynthesis. Methyl jasmonate treatment led to increased terpenoid content. This research provides insights for understanding and manipulating terpenoid production in Z. armatum.

Liu X et al (2023).
Plant Genome.
PubMed:
38129947

Neurotoxicity study of ethyl acetate extract of Zanthoxylum armatum DC. on SH-SY5Y based on ROS mediated mitochondrial apoptosis pathway.

Summary

ZADC is a plant used medicinally but its methanol extract causes neurotoxicity in rats. However, the specific toxic substances and the mechanism of neurotoxicity are still unknown.

Guo J et al (2023).
J Ethnopharmacol.
PubMed:
37866465

Effect of Salicylic Acid Treatment on Disease Resistance to Coleosporium zanthoxyli in Chinese pepper (Zanthoxylum armatum).

Ren Y et al (2023).
Plant Dis.
PubMed:
37858967

Integrated Transcriptome and Metabolome Analysis Reveals the Molecular Mechanism of Rust Resistance in Resistant (Youkang) and Susceptive (Tengjiao) Zanthoxylum armatum Cultivars.

Han S et al (2023).
Int J Mol Sci.
PubMed:
37834210

Investigation of the antimicrobial, antioxidant, hemolytic, and thrombolytic activities of Camellia sinensis, Thymus vulgaris, and Zanthoxylum armatum ethanolic and methanolic extracts.

Summary

Thyme and green tea extracts showed antimicrobial, antioxidant, hemolytic, and thrombolytic activities. These properties can be beneficial in treating diseases like cancer, diabetes, and respiratory diseases, and can be used as functional ingredients in food and drinks.

Rafique S et al (2023).
Food Sci Nutr.
PubMed:
37823136

Zanthoxylum armatum DC fruit ethyl acetate extract site induced hepatotoxicity by activating endoplasmic reticulum stress and inhibiting autophagy in BRL-3A models.

Zhang J et al (2023).
J Ethnopharmacol.
PubMed:
37802376

Revealing the mechanism of Zanthoxylum armatum DC. extract-induced liver injury in mice based on lipidomics.

Yang N et al (2023).
J Ethnopharmacol.
PubMed:
37634752

Phytochemical screening of Zanthoxylum armatum roots and exploring its polyphenol content and antioxidant activity.

Summary

This study analyzed the chemical composition of root extracts using GC-MS and HPLC-PDA and found 37 phytochemicals. The extract contained polyphenols and showed antioxidant activity.

Agnihotri S et al (2023).
Nat Prod Res.
PubMed:
37565659

Karyotype and Phylogenetic Relationship Analysis of Five Varieties and Cultivars of Zanthoxylum armatum Based on Oligo-FISH.

He Z et al (2023).
Genes (Basel).
PubMed:
37510363

Ethylene-induced improvement in photosynthetic performance of Zanthoxylum armatum under reoxygenation conditions.

Wu J et al (2023).
Funct Plant Biol.
PubMed:
37491008

The Zanthoxylum armatum fruit's oil exterminates Candida cells by inhibiting ergosterol biosynthesis without generating reactive oxygen species.

Pasrija R et al (2023).
Int Microbiol.
PubMed:
37481507

The establishment of comprehensive quality evaluation model for flavor characteristics of green Sichuan pepper (Zanthoxylum armatum DC.) in Southwest China.

Liu J et al (2023).
Food Chem X.
PubMed:
37397205

A NAC transcription factor ZaNAC93 confers floral initiation, fruit development, and prickle formation in Zanthoxylum armatum.

Tang N et al (2023).
Plant Physiol Biochem.
PubMed:
37290134

Alkylamides from Zanthoxylum armatum DC. and their neuroprotective activity.

Summary

Researchers isolated and identified 15 alkylamides from the pericarps of Zanthoxylum armatum DC, a plant commonly used for medicinal purposes in Asia. Five of the compounds were previously unknown. The researchers found that compounds 2-4 had potential neuroprotective effects, reducing oxidative stress and increasing cell viability in human neuroblastoma cells. The study expands knowledge of alkylamide structures in Z. armatum and suggests the plant may have medicinal properties for neurodegenerative diseases.

Ye QN et al (2023).
Phytochemistry.
PubMed:
37146703

Comparative transcriptome analysis reveals hormone, transcriptional and epigenetic regulation involved in prickle formation in Zanthoxylum armatum.

Summary

This study investigated prickle formation in Z. armatum. Results suggest that phytohormones, transcription factors, and epigenetic modifications play roles in prickle initiation.

Tang N et al (2023).
Gene.
PubMed:
37068692

Anti-Inflammatory and Anti-Osteoclastogenesis Activities of Different Kinds of Zanthoxylum bungeanum Seed Oil in vitro.

Zhang B et al (2023).
Chem Biodivers.
PubMed:
37029634

Two Ferulic Acid Derivatives Inhibit Neuroinflammatory Response in Human HMC3 Microglial Cells via NF-κB Signaling Pathway.

Summary

Scientists investigated the potential of two compounds from a plant extract in reducing inflammation related to neurodegenerative diseases. Using a human microglial cell model, they found that trans-ferulic acid and methyl ferulate significantly reduced the production of inflammatory mediators and increased levels of an anti-inflammatory factor. Additionally, the compounds inhibited the activation of a signaling pathway involved in inflammation. These findings suggest that the compounds could be useful in treating neuroinflammatory diseases.

Li PL et al (2023).
Molecules.
PubMed:
36903325

Separation and Purification of Hydroxyl-α-Sanshool from Zanthoxylum armatum DC. by Silica Gel Column Chromatography.

Cheng J et al (2023).
Int J Mol Sci.
PubMed:
36834566

Genome-wide identification of HD-ZIP gene family and screening of genes related to prickle development in Zanthoxylum armatum.

Zhang X et al (2023).
Plant Genome.
PubMed:
36606521

Genome-wide identification, interaction of the MADS-box proteins in Zanthoxylum armatum and functional characterization of ZaMADS80 in floral development.

Tang N et al (2022).
Front Plant Sci.
PubMed:
36507394

Chemical composition, polyphenol contents and antioxidant activities of the 'Himalayan toothache relieving tree' (Zanthoxylum armatum DC.).

Agnihotri S, Dobhal P and Tamta S (2022).
Nat Prod Res.
PubMed:
36200684

Green synthesis, characterization, and antibacterial activity of silver nanoparticles using stem extract of Zanthoxylum armatum.

Habib U et al (2022).
Microsc Res Tech.
PubMed:
36125078

The complex genome and adaptive evolution of polyploid Chinese pepper (Zanthoxylum armatum and Zanthoxylum bungeanum).

Hu L et al (2023).
Plant Biotechnol J.
PubMed:
36117410

Zanthoxylum armatum DC. extract induces liver injury via autophagy suppression and oxidative damage by activation of mTOR/ULK1 pathway.

Huang Y et al (2022).
Toxicon.
PubMed:
35977614

Phenolic compounds of Zanthoxylum armatum DC as potential inhibitors of urease and SARS-CoV2 using molecular docking approach and with simulation study.

Summary

Researchers evaluated the anti-urease effects of compounds found in the leaves of Datura ceratocaula. Three phenolic compounds were identified and found to interact significantly with both urease and SARS-CoV2 vital proteins. Chlorogenic acid was the most effective in interacting with both urease and the coronavirus main protease, while gallic acid was effective in interacting with five spike proteins of SARS-CoV2. The compounds also passed several tests for drug-likeness and could potentially be used as antagonists of urease.

Chelleng N et al (2023).
Nat Prod Res.
PubMed:
35968637

Internal Transcribed Spacer (ITS) Region of Nuclear Ribosomal DNA as a Suitable DNA Barcode for Identification of Zanthoxylum armatum DC. from Manipur.

Devi ML et al (2022).
Mol Biotechnol.
PubMed:
35763198

Antispasmodic Potential of Medicinal Plants: A Comprehensive Review.

Review
Rauf A et al (2021).
Oxid Med Cell Longev.
PubMed:
34804367

Activation of ATM/Chk2 by Zanthoxylum armatum DC extract induces DNA damage and G1/S phase arrest in BRL 3A cells.

Jiang J et al (2022).
J Ethnopharmacol.
PubMed:
34775036

PRISMA Based Systematic Review: Pharmacognostic Study of Zanthoxylum armatum DC.

Review
Singh S, Kumar A and Semwal BC (2021).
Mini Rev Med Chem.
PubMed:
33390134

Zanthoxylum armatum DC.: Current knowledge, gaps and opportunities in Nepal.

Review
Phuyal N et al (2019).
J Ethnopharmacol.
PubMed:
30166217

Zanthoxylum armatum DC extracts from fruit, bark and leaf induce hypolipidemic and hypoglycemic effects in mice- in vivo and in vitro study.

Alam F, Saqib QNU and Ashraf M (2018).
BMC Complement Altern Med.
PubMed:
29463309