Zanthoxylum nitidum

Ethnobotanical Studies

Studies

Integration of High-Resolution LC-Q-TOF Mass Spectrometry and Multidimensional Chemical-Biological Analysis to Detect Nanomolar-Level Acetylcholinesterase Inhibitors from Different Parts of Zanthoxylum nitidum.

Summary

Study analyzed Zanthoxyli radix tea components for Alzheimer's. Root has strongest AChE inhibition. Nitidine, chelerythrine, and sanguinarine are key compounds. Potential for new treatments.

Neuroscience
Zhang JN et al (2024).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.4c00866
PubMed:
39045647

[Study on optimal harvesting period and rational medicinal parts of Zanthoxylum nitidum based on statistics of main effective components].

Meng LH et al (2024).
Zhongguo Zhong Yao Za Zhi.
DOI:
10.19540/j.cnki.cjcmm.20240315.102
PubMed:
39041148

Nitidine chloride inhibits mTORC1 signaling through ATF4-mediated Sestrin2 induction and targets IGF2R for lysosomal degradation.

Chen F et al (2024).
Life Sci.
DOI:
10.1016/j.lfs.2024.122918
PubMed:
39034027

Sesquilignans PD from Zanthoxylum nitidum var. tomentosum exerts antitumor effects via the ROS/MAPK pathway in liver cancer cells.

Summary

Scientists tested the compound sesquilignans on liver cancer cells. It significantly inhibited cell growth, induced cell death processes, and activated specific cell signaling pathways. This study demonstrates sesquilignans' potential as an anticancer agent through multiple mechanisms.

CancerImmunology
Fan CW et al (2024).
J Asian Nat Prod Res.
DOI:
10.1080/10286020.2024.2371032
PubMed:
38958633

Alkaloids from Zanthoxylum nitidum and their anti-proliferative activity against A549 cells by regulating the EGFR/AKT/mTOR pathway.

Summary

Ten alkaloids isolated from showed significant antiproliferative effects against A549 cancer cells. Compound induced cell cycle arrest and inhibited cell migration through the EGFR/AKT/mTOR signaling pathway. Potential lead antiproliferative compound in cancer cells.

CancerPhytochemistry
Wang FF et al (2024).
Nat Prod Res.
DOI:
10.1080/14786419.2024.2347463
PubMed:
38684029

The Therapeutic Potential of Four Main Compounds of Zanthoxylum nitidum (Roxb.) DC: A Comprehensive Study on Biological Processes, Anti-Inflammatory Effects, and Myocardial Toxicity.

Summary

Research on compounds from shows potential therapeutic effects in cardiovascular diseases, including anti-inflammatory properties and impact on ion channels in cardiomyocytes. Findings suggest using these compounds for cardiovascular treatment.

CardiologyImmunology
Li X et al (2024).
Pharmaceuticals (Basel).
DOI:
10.3390/ph17040524
PubMed:
38675484

SSR molecular marker developments and genetic diversity analysis of Zanthoxylum nitidum (Roxb.) DC.

Zhu Y et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-48022-7
PubMed:
38008750

Comparison of the bioactive components and antioxidant activities of wild-type Zanthoxylum nitidum roots from various regions of Southern China.

Immunology
He J et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2023.2284264
PubMed:
37990844

Dynamic changes in the levels of metabolites and endogenous hormones during the germination of Zanthoxylum nitidum (Roxb.) DC. Seeds.

Wang L et al (2023).
Plant Signal Behav.
DOI:
10.1080/15592324.2023.2251750
PubMed:
37639213

Characterization of Silver Nanoparticles Synthesized by the Aqueous Extract of Zanthoxylum nitidum and Its Herbicidal Activity against Bidens pilosa L.

Jiang T et al (2023).
Nanomaterials (Basel).
DOI:
10.3390/nano13101637
PubMed:
37242051

Comparison of production of bioactive components in Zanthoxylum nitidum taproots from different regions in southern China.

Yang Y et al (2023).
Biomed Chromatogr.
DOI:
10.1002/bmc.5602
PubMed:
36779508

Nitidine chloride, a benzophenanthridine alkaloid from Zanthoxylum nitidum (Roxb.) DC., exerts multiple beneficial properties, especially in tumors and inflammation-related diseases.

Review ImmunologyPhytochemistry
Lu Q et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.1046402
PubMed:
36506558

Insight into the inhibitory effects of Zanthoxylum nitidum against Helicobacter pylori urease and jack bean urease: Kinetics and mechanism.

Lu Q, Li C and Wu G (2020).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2019.112419
PubMed:
31759110