Ziziphus spina-christi

Ethnobotanical Studies

Studies

Green synthesis of trimetallic CuO/Ag/ZnO nanocomposite using Ziziphus spina-christi plant extract: characterization, statistically experimental designs, and antimicrobial assessment.

Summary

Ziziphus spina christi leaves used to synthesize trimetallic CuO/Ag/ZnO nanocomposite with antimicrobial properties. Enhanced yield through Taguchi approach. Effective against multidrug-resistant bacteria, reducing viable counts and biofilm formation.

Antimicrobial
El-Sawaf AK et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-67579-5
PubMed:
39181914

Ethnobotanical study of medicinal plants used to treat human ailments in Quara district, northwestern Ethiopia.

Ethnobotany
Tadesse D, Masresha G and Lulekal E (2024).
J Ethnobiol Ethnomed.
DOI:
10.1186/s13002-024-00712-w
PubMed:
39127690

Traditional knowledge of wild plants on traditional tools, materials, products and economic practices in southern Yemen.

Al-Fatimi M et al (2024).
J Ethnobiol Ethnomed.
DOI:
10.1186/s13002-024-00698-5
PubMed:
38898489

Ziziphus spina-christi L. extract attenuates bleomycin-induced lung fibrosis in mice via regulating TGF-β1/SMAD pathway: LC-MS/MS Metabolic profiling, chemical composition, and histology studies.

Elhady SS et al (2024).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2024.116823
PubMed:
38834008

Ultrasonic-assisted extraction and UHPLC determination of ascorbic acid, polyphenols, and half-maximum effective concentration in Citrus medica and Ziziphus spina-christi fruits using multivariate experimental design.

Belayneh Asfaw T et al (2024).
Food Chem X.
DOI:
10.1016/j.fochx.2024.101310
PubMed:
38645936

Antimicrobial secondary metabolites and antioxidant activities of fungal endophytes associated with Ziziphus spina-christi (L.) Desf. (Nabq) leaves.

Summary

Twenty endophytic fungi from (L.) Desf. leaves showed promising antimicrobial activity against bacteria and fungi. They also displayed antioxidant activity. This study highlights their potential as sources of natural antioxidants and antimicrobial agents.

AntimicrobialImmunology
Farouk HM et al (2024).
Nat Prod Res.
DOI:
10.1080/14786419.2024.2340761
PubMed:
38630967

Exploring the potential of Ziziphus nummularia and luteolin-7-O-glucoside as tubulin inhibitors in cancer therapy and survival.

Summary

Ziziphus nummularia and Ziziphus spina-christi extracts show potential as anti-cancer agents, particularly ethanolic extract of Z. nummularia. Luteolin-7-O-glucoside is a promising candidate for further research due to its potent activity against cancer cells. Herbal treatment may activate cancer cell survival mechanisms.

Cancer
Alghamdi SS et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-57680-0
PubMed:
38531974

Predicting anti-COVID-19 potential: in silico analysis of Mauritine compound from Ziziphus-spina christi as a promising papain-like protease (PLpro) inhibitor.

Summary

Researchers studied the antiviral effects of the plant compound Mauritine on COVID-19 protease. Mauritine-A and Mauritine-C show promise with strong binding affinity and stability. This could lead to potential COVID-19 treatments.

COVID-19
Fakih TM et al (2024).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2024.2322627
PubMed:
38529845

Potential Parasitoids for Biocontrol of the Ber Fruit Fly, Carpomya vesuviana Costa (Diptera: Tephritidae).

Amini A et al (2023).
Life (Basel).
DOI:
10.3390/life14010050
PubMed:
38255665

Performance, blood and antioxidant status in dual-purpose laying hens supplemented with aqueous extract of Christ's thorn jujube (Ziziphus spina-christi L.) leaves as phytogenic agent in subtropical conditions.

Immunology
El-Kholy KH et al (2024).
Anim Biosci.
DOI:
10.5713/ab.23.0243
PubMed:
38228130

Mainstreaming traditional fruits, vegetables and pulses for nutrition, income, and sustainability in sub-Saharan Africa: the case for Kenya and Ethiopia.

Ngigi PB et al (2023).
Front Nutr.
DOI:
10.3389/fnut.2023.1197703
PubMed:
38146328

Evaluation of antimicrobial and antioxidant activity of zinc oxide nanoparticles biosynthesized with Ziziphus spina-christi leaf extracts.

Summary

Green synthesized zinc oxide nanoparticles (ZnO-NPs) using an aqueous leaf extract show strong antioxidant and antimicrobial activities. ZnO-NPs have potential as antimicrobial agents against various bacteria and fungi.

AntimicrobialImmunology
Shnawa BH et al (2023).
J Environ Sci Health C Toxicol Carcinog.
DOI:
10.1080/26896583.2023.2293443
PubMed:
38105670

Silver-cored Ziziphus spina-christi extract-loaded antimicrobial nanosuspension: overcoming multidrug resistance.

Summary

Scientists developed a silver-cored nanosuspension using fresh-leaf extract. It effectively fought drug-resistant pathogens, inhibited biofilm formation, and showed promise as an antimicrobial agent against multidrug-resistant pathogens.

Antimicrobial
Hussein NN et al (2023).
Nanomedicine (Lond).
DOI:
10.2217/nnm-2023-0185
PubMed:
37982771

Green Lead Nanoparticles Induced Apoptosis and Cytotoxicity in MDA-MB-231 Cells by Inducing Reactive Oxygen Species and Caspase 3/7 Enzymes.

Alsulami WL et al (2023).
Dose Response.
DOI:
10.1177/15593258231214364
PubMed:
37953942

Use of wild edible and nutraceutical plants in Raya-Azebo District of Tigray Region, northern Ethiopia.

Giday M and Teklehaymanot T (2023).
Trop Med Health.
DOI:
10.1186/s41182-023-00550-8
PubMed:
37872596

Exploring the anti-obesity bioactive compounds of Thymelaea hirsuta and Ziziphus spina-christi through integration of lipase inhibition screening and molecular docking analysis.

Summary

Scientists isolated eight compounds with pancreatic lipase inhibitory activity from the plants and . These compounds showed significant inhibitory effects on lipase and have the potential to be used as potent lipase inhibitors.

Obesity
Abdallah RM et al (2023).
RSC Adv.
DOI:
10.1039/d3ra05826c
PubMed:
37701277

Antifungal potentiality of mycogenic silver nanoparticles capped with chitosan produced by endophytic Amesia atrobrunnea.

Summary

This research developed silver nanoparticles (AgNPs) from an endophytic fungus and encapsulated them with chitosan. Optimal conditions for synthesis were determined and the nanoparticles were characterized. Chitosan-coated AgNPs showed antifungal activity against various pathogens.

Antimicrobial
Saeed Al-Zahrani S and Mohammed Al-Garni S (2023).
Saudi J Biol Sci.
DOI:
10.1016/j.sjbs.2023.103746
PubMed:
37645687

Enhanced immune responses in dexamethasone immunosuppressed male rats supplemented with herbal extracts, chitosan nanoparticles, and their conjugates.

Milad SS et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.126170
PubMed:
37573907

In Vitro Antiproliferative Apoptosis Induction and Cell Cycle Arrest Potential of Saudi Sidr Honey against Colorectal Cancer.

Summary

Sidr honey from Saudi Arabia was tested on colorectal, breast, and lung cancer cells. It showed potential as an antitumor agent by inducing apoptosis and cell cycle arrest. Further research is needed to identify and understand the active compounds.

CancerGastroenterology
Qanash H et al (2023).
Nutrients.
DOI:
10.3390/nu15153448
PubMed:
37571386

GC-MS Analysis, Antibacterial, and Anticancer Activities of Hibiscus sabdariffa L. Methanolic Extract: In Vitro and In Silico Studies.

Summary

A study was conducted to investigate the effectiveness of various extracts from three medicinal plants (A, B, and C) against pathogenic bacteria. The methanol extract from plant A exhibited the highest antibacterial efficacy against all tested bacteria, including multidrug-resistant strains. Additionally, a combination of plant A and a certain antibiotic showed promising results. Furthermore, plant A showed potential anticancer activity against colon cancer cells. Analysis confirmed the presence of bioactive components in the methanol extract. Molecular docking suggested that these components could inhibit the tested substances, offering potential applications in the treatment of infections and colon cancer. Overall, the methanol extract from plant A shows promise as a natural therapy for treating infections.

Cancer
Sehim AE et al (2023).
Microorganisms.
DOI:
10.3390/microorganisms11061601
PubMed:
37375103

Anti-angiogenic and anti-proliferative activity of ziziphus leaf extract as a novel potential therapeutic agent for reducing hepatic injury in experimental hamster schistosomiasis.

Summary

This study investigates the potential of Ziziphus spina-christi leaf extract (ZLE) in treating hepatic schistosomiasis. The researchers explore the anti-angiogenic and anti-proliferative activity of ZLE in reducing hepatic injury caused by the disease. The study aims to evaluate the therapeutic potential of ZLE as an anti-angiogenic and anti-proliferative agent in hamsters infected with S. mansoni, shedding light on a possible mechanism for controlling the disease. This research is significant as it may contribute to the development of new treatment strategies for schistosomiasis, which is a major global health issue.

Cancer
Alghamdi T, Salem DA and El-Refaei MF (2023).
PLoS Negl Trop Dis.
DOI:
10.1371/journal.pntd.0011426
PubMed:
37339146

The traditional use of wild edible plants in pastoral and agro-pastoral communities of Mieso District, eastern Ethiopia.

Tahir M et al (2023).
Trop Med Health.
DOI:
10.1186/s41182-023-00505-z
PubMed:
36814353

Antioxidant, Cytotoxic, and DNA Damage Protection Activities of Endophytic Fungus Pestalotiopsis neglecta Isolated from Ziziphus spina-christi Medicinal Plant.

Genetics
Almustafa HI and Yehia RS (2023).
Microorganisms.
DOI:
10.3390/microorganisms11010117
PubMed:
36677409

Ziziphus spina-christi extract-stabilized novel silver nanoparticle synthesis for combating Fusarium oxysporum-causing pepper wilt disease: in vitro and in vivo studies.

Abdelaziz AM et al (2023).
Arch Microbiol.
DOI:
10.1007/s00203-023-03400-7
PubMed:
36670250

The effects of Ziziphus Spina leaves' Hydro-Alcoholic Extract Vaginal Cream and Clotrimazole on Candida albicans in Wistar Rats.

Honarmandpour A et al (2022).
Clin Pathol.
DOI:
10.1177/2632010X221138664
PubMed:
36438542

Biogenic synthesis of reduced graphene oxide from Ziziphus spina-christi (Christ's thorn jujube) extracts for catalytic, antimicrobial, and antioxidant potentialities.

Antimicrobial
Mahmoud AED et al (2022).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-022-21871-x
PubMed:
35859234

Solubility enhancement of some poorly soluble drugs by solid dispersion using Ziziphus spina-christi gum polymer.

Alwossabi AM et al (2022).
Saudi Pharm J.
DOI:
10.1016/j.jsps.2022.04.002
PubMed:
35812143

Ethnopharmacology, Biological Evaluation, and Chemical Composition of Ziziphus spina-christi (L.) Desf.: A Review.

Review Ethnobotany
Abdulrahman MD et al (2022).
Adv Pharmacol Pharm Sci.
DOI:
10.1155/2022/4495688
PubMed:
35677711

Nutritional and ecoclimatic importance of indigenous and naturalized wild edible plant species in Ethiopia.

Mokria M et al (2022).
Food Chem (Oxf).
DOI:
10.1016/j.fochms.2022.100084
PubMed:
35415697

Ultrasonic-assisted synthesis of zeolite/activated carbon@MnO(2) composite as a novel adsorbent for treatment of wastewater containing methylene blue and brilliant blue.

Shojaei M and Esmaeili H (2022).
Environ Monit Assess.
DOI:
10.1007/s10661-022-09930-9
PubMed:
35290530

Role of Herbal Medicines in the Management of Brain Injury.

Summary

This review evaluated studies on the role of herbal medicines in managing brain injury. Researchers searched various databases and found 32 studies with medicinal plants like Ginkgo biloba and olive that showed significant improvements in brain injury. The plants worked through different mechanisms, such as reducing free radicals and nitric oxide toxicity and increasing neuronal density. The review summarized the neuroprotective actions and molecular mechanisms of each plant. Overall, herbal medicines show promise in preventing and managing brain injury.

Review Neuroscience
Safdari MR et al (2021).
Adv Exp Med Biol.
DOI:
10.1007/978-3-030-73234-9_19
PubMed:
34981485

Antileishmanial Activity of Ziziphus spina-christi Leaves Extract and Its Possible Cellular Mechanisms.

Albalawi AE et al (2021).
Microorganisms.
DOI:
10.3390/microorganisms9102113
PubMed:
34683434

Ziziphus spina-christi leaf extract attenuates mercuric chloride-induced liver injury in male rats via inhibition of oxidative damage.

Ramadan SS et al (2021).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-020-12160-6
PubMed:
33394435

Ziziphus spina-christi Leaf Extract Mitigates Mercuric Chloride-induced Cortical Damage in Rats.

Almeer RS et al (2022).
Comb Chem High Throughput Screen.
DOI:
10.2174/1386207323666201204124412
PubMed:
33280592

Ziziphus spina-christi leaf extract attenuates mercury chloride-induced testicular dysfunction in rats.

Almeer RS et al (2020).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-019-07237-w
PubMed:
31840221

Ziziphus spina-christi leaves methanolic extract alleviates diethylnitrosamine-induced hepatocellular carcinoma in rats.

El-Din MS et al (2019).
Biochem Cell Biol.
DOI:
10.1139/bcb-2018-0318
PubMed:
30605366