Review

Mucuna pruriens in Parkinson's and in some other diseases: recent advancement and future prospective.

This review explores the therapeutic potential of Mucuna pruriens (Mp), a legume known for its antioxidant, anti-inflammatory, and anti-microbial properties. Mp has been widely used as an aphrodisiac and has been shown to have neuroprotective effects in Parkinson's disease (PD) models. The important constituents responsible for the anti-Parkinsonian activity of Mp are levodopa (L-DOPA), ursolic acid, and betulinic acid. The seeds of Mp are rich in L-DOPA and have been found to exhibit potent neuroprotective attributes in toxin-induced PD models. Clinical trials on anti-PD activity of Mp have shown convincing results. Mp also shows therapeutic activity in diseases such as cancer, diabetes, skin infection, and anemia. However, further studies are needed to validate its efficacy in other neurodegenerative diseases.

Rai SN et al (2020).
3 Biotech.
PubMed:
33194526