Polygalae Radix: A review of its traditional uses, phytochemistry, pharmacology, toxicology, and pharmacokinetics.
- Zhao X et al (2020).
- Fitoterapia.
- PubMed:
- 33069838
Despite global efforts, a specific therapy or vaccine against COVID-19 remains elusive. Prevention and intervention through isolation, hygiene measures, diagnosis, and treatment are the most effective ways to combat the virus. Health organizations and global care systems have screened available resources and recommended approved and proposed medications. The search for a targeted therapy or vaccine continues as the world battles this unprecedented enemy.
Nigella sativa seed and its active compounds have been historically recognized as an effective herbal panacea that can promote a healthy immune response and suppress chronic inflammation. Recent findings suggest that N. sativa could be a potential candidate in nutraceuticals to prevent and cure COVID-19. The review aims to revisit the pharmacological benefits of N. sativa seed and its active metabolites that could be a potential basis for developing a novel preventive and therapeutic strategy against COVID-19. Bioactive compounds of N. sativa seed, especially thymiquinone, α-hederin, and nigellidine, could be promising herbal drugs to combat COVID-19. Preclinical and clinical trials are required to investigate their efficacy and potency under specific pathophysiological conditions of COVID-19.
Scientists have identified 93 potential drug candidates from natural products such as medicinal plants and herbs that could effectively inhibit the coronavirus, including COVID-19. These candidates include pure compounds like Blancoxanthone and herbacetin, and extracts from plants like Artemisia annua and Tinospora cordifolia. The study suggests that natural products can be used as a source for potential drug discovery against COVID-19 and other respiratory viruses, including SARS and MERS-CoV. This provides a promising avenue for future research to develop effective treatments for the ongoing pandemic.