Review

Dl-3-n-Butylphthalide (NBP): A Promising Therapeutic Agent for Ischemic Stroke.

Ischemic stroke is a major cause of morbidity and mortality, with few treatment options. Recombinant tissue plasminogen activator (rtPA) is the only FDA-approved drug, but its strict therapeutic window limits its use. Dl-3-n-Butylphthalide (NBP), a synthetic compound derived from seeds of the Apium graveolens plant, has shown promise in treating ischemic stroke in multiple clinical studies. NBP has multiple mechanisms of action, including anti-oxidant, anti-inflammatory, anti-apoptotic, and anti-thrombotic effects, as well as protecting mitochondria. This review highlights the potential of NBP as a powerful multi-target therapy for ischemic stroke.

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