Review

The Pharmacological Activity of Garlic (Allium sativum) in Parkinson's Disease: From Molecular Mechanisms to the Therapeutic Potential.

Garlic has shown protective effects in models of Parkinson's Disease (PD) due to its anti-Parkinsonian activity through targeting oxidative stress, mitochondrial damage, and neuroinflammation-related signaling. However, the major bioactive components of garlic present stability issues and some adverse effects. This review explores the therapeutic potential of garlic and its constituents in PD, the molecular mechanisms responsible for its benefits, and the associated limitations that need to be overcome for clinical use. Garlic has potential as a treatment for PD, but more research is needed to develop safer and more effective methods of delivery.

Rakshit D et al (2023).
ACS Chem Neurosci.
PubMed:
36861262