Neuroprotective Treatments for Digestive Forms of Chagas Disease in Experimental Models: A Systematic Review.
A systematic review was conducted to identify potential neuroprotective drugs for the digestive form of Chagas disease, which is currently treated ineffectively. Eight experimental studies on murine models were included, with most showing neuroprotective activity of the tested drugs (acetylsalicylic acid, cyclophosphamide, and Lycopodium clavatum 13c). However, further study on the mechanisms, safety, and immunogenicity of these drugs is needed. This study provides valuable insight for the development of improved treatments for Chagas disease.
- do Carmo Neto JR et al (2022).
- Oxid Med Cell Longev.
- DOI:
- 10.1155/2022/9397290
- PubMed:
- 36199427