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Chrysin, a natural molecule found in plants, has various health benefits such as antioxidant, anti-inflammatory, anti-cancer, neuroprotective, and anti-apoptotic effects. Researchers have found that chrysin also exhibits anxiolytic and antidepressant-like effects through its interaction with neurotransmitter systems, particularly the GABAergic and serotonergic, and activation of neurotrophic factors. The antioxidant and anti-inflammatory activities of chrysin may also contribute to its therapeutic use for anxiety and depression disorders. These pre-clinical findings suggest that chrysin could be a promising novel therapy for these disorders.