Antimicrobial Studies

Lancemaside A from Codonopsis lanceolata: Studies on Antiviral Activity and Mechanism of Action against SARS-CoV-2 and Its Variants of Concern.

Scientists evaluated Codonopsis lanceolata as a potential treatment for COVID-19 and found that the plant extract and its active compound, lancemaside A (LA), effectively blocked SARS-CoV-2 infection by altering membrane cholesterol and blocking membrane fusion between the virus and host cells. LA also impeded the entry pathways of several SARS-CoV-2 variants, including Omicron. Researchers suggest that LA has broad-spectrum anti-SARS-CoV-2 activity and may serve as a potential therapeutic option.

Kim TY et al (2022).
Antimicrob Agents Chemother.
PubMed:
36374087