Antimicrobial Studies

Structural interactions of phytoconstituent(s) from cinnamon, bay leaf, oregano, and parsley with SARS-CoV-2 nucleocapsid protein: A comparative assessment for development of potential antiviral nutraceuticals.

In a study, ten bioactive compounds were identified in four plants and assessed for their cytotoxic and antiviral properties against SARS-CoV-2. Apigenin, catechin, apiin, and cinnamic acid showed potential as prophylactic and therapeutic candidates in preventing or treating COVID-19. Using in silico biology tools, the researchers found that these compounds displayed a greater binding affinity to the N-terminal and C-terminal RNA binding domains of SARS-CoV-2 nucleocapsid protein than remdesivir. Molecular dynamics simulation confirmed the stability of the ligand-protein complexes. These findings highlight the potential of naturally occurring compounds as novel drug candidates against SARS-CoV-2.

Husain I et al (2022).
J Food Biochem.
PubMed:
35796388