Antimicrobial Studies

Clinical safety and pharmacokinetic evaluation of aqueous extract of Cocculus hirsutus, an anti-viral phytopharmacetical drug as a potential for the treatment of dengue and COVID-19.

Scientists have conducted a study on AQCH tablets as a potential treatment for dengue and COVID-19 infections. The study aimed to evaluate the safety and pharmacokinetics of AQCH in healthy human subjects. AQCH has shown to have anti-viral activity in in vitro and small animal studies. With no effective vaccine or drug available for dengue, this study brings hope for a potential treatment option. The results of this study suggest that AQCH tablets are safe and well-tolerated in humans, and could be a promising solution in the fight against dengue and COVID-19.

Dar SK et al (2022).
Heliyon.
PubMed:
35582330

GC-MS analysis of phytoconstituents from Ruellia prostrata and Senna tora and identification of potential anti-viral activity against SARS-CoV-2.

Researchers identified natural compounds that can inhibit the activity of the SARS-CoV-2 main protease, which plays a critical role in viral replication. Through computational methods such as molecular docking and simulations, four compounds were identified with good pharmacokinetics and toxicity properties: PubChem CID 70825, CID 25247358, CID 54685836, and CID 1983. Experimental validation is still needed, but these compounds show promise as potential therapeutics for COVID-19.

Alam R et al (2021).
RSC Adv.
PubMed:
35494115