Antiviral Action of Tryptanthrin Isolated from Strobilanthes cusia Leaf against Human Coronavirus NL63.

Researchers investigated the antiviral properties of the Chinese herbal medicine, (Nees) Kuntze, against the Human coronavirus NL63 (HCoV-NL63), which commonly infects the immunocompromised, children, and elderly. The methanol extract of the plant's leaves and its major components, such as tryptanthrin and indigodole B, effectively inhibited the virus' ability to reproduce and cause cellular damage in infected cells. Tryptanthrin, in particular, prevented various stages of the virus' replication process, including blocking viral RNA genome synthesis and protease activity. The study highlights the potential of the plant extract and its components to combat respiratory viral infections caused by HCoV-NL63.

Tsai YC et al (2020).

Biomolecules.

DOI:

10.3390/biom10030366

PubMed:

32120929

Cytotoxic, Antimicrobial, Antioxidant Properties and Effects on Cell Migration of Phenolic Compounds of Selected Transylvanian Medicinal Plants.

Csepregi R et al (2020).

Antioxidants (Basel).

DOI:

10.3390/antiox9020166

PubMed:

32085594

Antimicrobial Activity of Essential Oils against Staphylococcus and Malassezia Strains Isolated from Canine Dermatitis.

Ebani VV et al (2020).

Microorganisms.

DOI:

10.3390/microorganisms8020252

PubMed:

32069976

Preliminary Antimicrobial Profile of Solanum incanum L.: A Common Medicinal Plant.

Sbhatu DB and Abraha HB (2020).

Evid Based Complement Alternat Med.

DOI:

10.1155/2020/3647065

PubMed:

32063983

Thymus vulgaris essential oil and thymol inhibit biofilms and interact synergistically with antifungal drugs against drug resistant strains of Candida albicans and Candida tropicalis.

Jafri H and Ahmad I (2020).

J Mycol Med.

DOI:

10.1016/j.mycmed.2019.100911

PubMed:

32008964

Volatile Compositions and Antifungal Activities of Native American Medicinal Plants: Focus on the Asteraceae.

Lawson SK et al (2020).

Plants (Basel).

DOI:

10.3390/plants9010126

PubMed:

31963839

Chemical Composition and the Cytotoxic, Antimicrobial, and Anti-Inflammatory Activities of the Fruit Peel Essential Oil from Spondias pinnata (Anacardiaceae) in Xishuangbanna, Southwest China.

Li R et al (2020).

Molecules.

DOI:

10.3390/molecules25020343

PubMed:

31952118

Phytochemical Characterization and In Vitro Anti-Inflammatory, Antioxidant and Antimicrobial Activity of Combretum collinum Fresen Leaves Extracts from Benin.

Marquardt P et al (2020).

Molecules.

DOI:

10.3390/molecules25020288

PubMed:

31936854