GeoBotanical: Arthritis Studies

1.

Exploring Potential Bioactive Components of Persea americana for the Treatment of Rheumatoid Arthritis through Network Pharmacology.

Study used network pharmacology to find potential compounds from avocados for treating rheumatoid arthritis. Important as current RA treatments have limitations, need for new options is crucial.

Arthritis Persea americana

Akey KS et al (2024).; Curr Rheumatol Rev.
DOI:: 10.2174/0115733971294872240801113559
PubMed:: 39177142

2.

Using terahertz spectroscopy to quantify bioactive flavonoids in Moxa Wool as predictor of rheumatoid arthritis treatment outcomes.

Arthritis Phytochemistry Artemisia argyi

Shao Y et al (2024).; Phytomedicine.
DOI:: 10.1016/j.phymed.2024.155927
PubMed:: 39096543

3.

Effect of Xanthohumol from Humulus lupulus L. Against Gouty Bone Damage in Arthritis of Rats Induced by Mono-sodium Urate.

Arthritis Humulus lupulus

Han J et al (2024).; Cell Biochem Biophys.
DOI:: 10.1007/s12013-024-01429-z
PubMed:: 39033477

4.

Exploring the pharmacological mechanisms of the flower of Rhododendron molle in rheumatoid arthritis rats based on metabolomics integrated network pharmacology.

Arthritis Rhododendron molle

Guo X et al (2024).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2024.118524
PubMed:: 38971344

5.

Mangiferin: A natural bioactive immunomodulating glucosylxanthone with potential against cancer and rheumatoid arthritis.

Summary: Mangiferin from Mangifera indica has immunomodulatory effects, potential for treating rheumatoid arthritis and cancer by blocking NF-κB, regulating various pathways, activating macrophages, and having proapoptotic effects. Its precise mechanisms are still unknown.$total synthesis screened in vitro & in vivo.

Arthritis Cancer Mangifera indica

Akkewar AS, Mishra KA and Sethi KK (2024).; J Biochem Mol Toxicol.
DOI:: 10.1002/jbt.23765
PubMed:: 38967724

6.

[Terminalia chebula water extract reduces joint inflammation by regulating cellular immunity in spleen cells of collagen-induced arthritis (CIA) rats through up-regulation of PD-1/PD-L1].

Arthritis Immunology Terminalia chebula

Wu Q et al (2024).; Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi.
PubMed:: 38952088

7.

Onion (Allium cepa L.) Flavonoid Extract Ameliorates Osteoporosis in Rats Facilitating Osteoblast Proliferation and Differentiation in MG-63 Cells and Inhibiting RANKL-Induced Osteoclastogenesis in RAW 264.7 Cells.

Arthritis Phytochemistry Allium cepa

Zhang D et al (2024).; Int J Mol Sci.
DOI:: 10.3390/ijms25126754
PubMed:: 38928460

8.

Using broadly targeted plant metabolomics technology combined with network pharmacology to explore the mechanism of action of the Yishen Gushu formula in the treatment of postmenopausal osteoporosis in vivo.

YSGSF boosts bone density by enhancing bone metabolism, but how it treats PMOP is unknown. Study the effects of YSGSF on PMOP to enhance treatment strategies.

Arthritis Endocrinology Panax notoginseng

Liu H et al (2024).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2024.118469
PubMed:: 38914151