Withaferin A Alleviates Inflammation in Animal Models of Arthritis by Inhibiting the NF-κB Pathway and Cytokine Release.

Alenazi F et al (2024).

Chem Biol Interact.

DOI:

10.1016/j.cbi.2024.111114

PubMed:

38897341

Epimedii Folium decoction ameliorates osteoporosis in mice through NLRP3/caspase-1/IL-1β signalling pathway and gut-bone axis.

Ma F et al (2024).

Int Immunopharmacol.

DOI:

10.1016/j.intimp.2024.112472

PubMed:

38897131

In silico and in vitro studies for the identification of small molecular inhibitors from Euphorbia hirta Linn for rheumatoid arthritis: targeting TNF-α-mediated inflammation.

Velmurugan Y et al (2024).

Mol Divers.

DOI:

10.1007/s11030-024-10900-1

PubMed:

38884873

Structure-activity relationships of natural and synthetic lathyrane-based diterpenoids for suppression of NLRP3-driven inflammation and gouty arthritis.

Zhuang Y et al (2024).

Bioorg Chem.

DOI:

10.1016/j.bioorg.2024.107558

PubMed:

38878755

Untargeted metabolomics revealed the mechanism of aucubin on glucocorticoid-induced osteoporosis in mice through modulating arachidonic acid metabolism.

Wang H et al (2024).

J Pharm Biomed Anal.

DOI:

10.1016/j.jpba.2024.116273

PubMed:

38878451

Ephedra sinica polysaccharide regulate the anti-inflammatory immunity of intestinal microecology and bacterial metabolites in rheumatoid arthritis.

ESP, a polysaccharide, has strong therapeutic effects on rheumatoid arthritis. The gut microbiota enzymes and derivatives play a role in the inflammatory immune response in RA. Important for potential treatment development.

Ma Y et al (2024).

Front Pharmacol.

DOI:

10.3389/fphar.2024.1414675

PubMed:

38846095

Therapeutic effect of Periploca forrestii on collagen-induced arthritis in rats through JAK2/Nf-κB pathway.

Chinese herbal medicine has potential therapeutic effects on rheumatoid arthritis, as confirmed through chemical analysis and testing on rats. Understanding its mechanisms could lead to new treatments for this chronic autoimmune disease.

Zhang Z et al (2024).

Front Pharmacol.

DOI:

10.3389/fphar.2024.1415392

PubMed:

38841364

The antiangiogenic effect of total saponins of Panax japonicus C.A. Meyer in rheumatoid arthritis is mediated by targeting the HIF-1α/VEGF/ANG-1 axis.

Researchers extracted TSPJs from Panax japonicus C.A. Meyer, a traditional Chinese herbal medicine used to treat rheumatoid arthritis. The anti-inflammatory mechanism of TSPJs needs further investigation.

Guo X et al (2024).

J Ethnopharmacol.

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10.1016/j.jep.2024.118422

PubMed:

38838922