Traditional Chinese Medicine in Osteoporosis Intervention and the Related Regulatory Mechanism of Gut Microbiome.

TCM can influence the gut microbiome to combat osteoporosis. This is because the gut microbiome affects inflammation, hormone levels, nutrient absorption, and bone mass. TCM herbs can regulate the gut microbiome and indirectly impact bone health. Puerarin specifically improves intestinal health and reduces inflammation caused by estrogen deficiency.

Li K et al (2023).

Am J Chin Med.

DOI:

10.1142/S0192415X23500866

PubMed:

37884447

Tripterygium hypoglaucum extract ameliorates adjuvant-induced arthritis in mice through the gut microbiota.

Hu J et al (2023).

Chin J Nat Med.

DOI:

10.1016/S1875-5364(23)60466-2

PubMed:

37879792

Attenuation of CFA-induced arthritis through regulation of inflammatory cytokines and antioxidant mechanisms by Solanum nigrum L. leaves extracts.

The study evaluated the anti-arthritic effects of Solanum nigrum L. extracts. Results showed significant pain relief and reduction in inflammation. Extracts regulated inflammatory markers and improved oxidative stress, suggesting potential in treating arthritis.

Gul B et al (2023).

Inflammopharmacology.

DOI:

10.1007/s10787-023-01357-z

PubMed:

37864683

Crocus sativus L. Extract (Saffron) Effectively Reduces Arthritic and Inflammatory Parameters in Monotherapy and in Combination with Methotrexate in Adjuvant Arthritis.

Researchers investigated the potential benefits of saffron extract (SF) as a monotherapy and in combination with methotrexate (MTX) for rheumatoid arthritis. Results showed that SF alone and in combination with MTX improved biometric, immunological, and biochemical parameters, suggesting SF's anti-arthritic and anti-inflammatory potential.

Chrastina M et al (2023).

Nutrients.

DOI:

10.3390/nu15194108

PubMed:

37836391

Efficacy evaluation and metabolomics analysis of raw and salt-processed Achyranthes bidentata Radix in zebrafish larvae for osteoporosis treatment.

Jiang E et al (2023).

J Pharm Biomed Anal.

DOI:

10.1016/j.jpba.2023.115774

PubMed:

37832477

Anti-Rheumatoid Arthritis Pharmacodynamic Substances Screening of Periploca forrestii Schltr.: Component Analyses In Vitro and In Vivo Combined with Multi-Technical Metabolomics.

Sun J et al (2023).

Int J Mol Sci.

DOI:

10.3390/ijms241813695

PubMed:

37761998

Anti-osteoporosis effects of triterpenoids from the fruit of sea buckthorn (Hippophae rhamnoides) through the promotion of osteoblast differentiation in mesenchymal stem cells, C3H10T1/2.

Researchers isolated bioactive compounds from sea buckthorn fruits. Triterpenes and fatty acids promoted osteoblast differentiation and increased expression of bone formation-related genes. Ursolic aldehyde showed the most potent effect and could potentially be used to promote bone health.

Lee DE et al (2023).

Arch Pharm Res.

DOI:

10.1007/s12272-023-01468-9

PubMed:

37751030

Suppressive effect of Tripterygium hypoglaucum (Levl.) Hutch extract on rheumatoid arthritis in mice by modulating inflammasome and bile acid metabolism.

Zheng J et al (2023).

Biomed Pharmacother.

DOI:

10.1016/j.biopha.2023.115494

PubMed:

37734264